Diindolylmethane + Abemaciclib
Abemaciclib brand name: Verzenio.
We found no known interaction between Diindolylmethane and Abemaciclib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Diindolylmethane and Abemaciclib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Abemaciclib and Diindolylmethane in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Diindolylmethane safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
DIM does have some theoretical drug interactions to be aware of, but they are generally believed to be only mild to moderate in nature.
Potential drug interactions with DIM include drugs in the following classes:
- Drugs that are metabolized by the liver enzyme CYP1A2: DIM may induce this enzyme, increasing the metabolism of certain drugs.
- Diuretics: DIM may reduce sodium levels, and could have additive effects with diuretics that increase sodium loss.
- Estrogen: DIM may have both estrogenic and anti-estrogen effects.
These are all detailed in individual interaction pages.
There is no known interaction between DIM and the drug in question, however.
Nevertheless, always be sure to tell your doctor about all the medications you are taking, supplements included.
Why No Interaction Is Listed for Abemaciclib
Interactions in our licensed database are recorded against drug classes, not just single drug names. Abemaciclib is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Diindolylmethane has documented interactions with 3 drug classes — the most serious being diuretic drugs (moderate), estrogens (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (minor) — and none of Abemaciclib’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Diindolylmethane Does Interact With Other Medications
Diindolylmethane has 116 moderate, 153 minor known drug interactions in our database — Abemaciclib isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Diindolylmethane
We haven’t checked that one against Diindolylmethane yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Diindolylmethane. Pick one to open its full report.
Diindolylmethane in Pregnancy & Breastfeeding
When used orally in amounts commonly found in foods. The typical diet supplies 2-24 mg of diindolylmethane daily. There is insufficient reliable information available about the safety of diindolylmethane when used in amounts greater than those found in foods during pregnancy and lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Abemaciclib Is Prescribed For, and What Diindolylmethane Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Abemaciclib is a prescription medicine with approved uses on its FDA label. Diindolylmethane is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Abemaciclib is prescribed for: Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back. For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.
Diindolylmethane has been studied for:
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Breast cancer studied, not established Diindolylmethane has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Diindolylmethane for breast cancer
It is unclear if oral diindolylmethane is beneficial in patients at high risk for developing breast cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Abemaciclib on your own; if you are taking Diindolylmethane for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Diindolylmethane or Abemaciclib
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Diindolylmethane or Abemaciclib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does DIM (Diindolylmethane) Interact With Any Drugs? ›
- Is DIM (Diindolylmethane) Safe To Take With Antibiotics? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Abemaciclib
This page covers Diindolylmethane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Abemaciclib page lists 138 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 94 moderate · 41 minor.
From our pharmacist’s overview on the Abemaciclib page
“A daily pill for a common form of advanced breast cancer, abemaciclib (Verzenio) only helps when its blood level stays steady, so this list of 138 supplements deserves genuine care. Nearly all of them act on CYP3A4, the liver enzyme that clears abemaciclib, meaning a supplement can push its level up and intensify side effects, or drag…”
Reviewed by 2 · Jul 18, 2026
Taking Diindolylmethane as Part of a Dietary Supplement Product? Check It for Interactions
We hold 933 real supplement products containing Diindolylmethane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Diindolylmethane. Even though Diindolylmethane itself has no known interaction with Abemaciclib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Diindolylmethane and Abemaciclib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#199 of 1,452 supplements looked up here in the last 7 days
#35 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Diindolylmethane reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Diindolylmethane and Abemaciclib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Diindolylmethane
What is Diindolylmethane?
- Estrogen/hormone balance
- Acne and hormonal skin issues
- Prostate health support
- Cancer-risk reduction (unproven)
- PMS and menopause symptoms
- General 'detox' support
Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab studies look interesting, strong human evidence is lacking for most of these uses. Talk with your pharmacist or doctor before taking DIM, especially if you have a hormone-sensitive condition.
A compound formed from indole-3-carbinol found in cruciferous vegetables (broccoli, cabbage, kale, Brussels sprouts) · Capsules, tablets, softgels (often combined with black pepper extract/BioPerine for absorption)
An interaction check asks whether these two react with each other — it does not ask whether Diindolylmethane is a good idea for someone in your situation. Here is what our Diindolylmethane record says about it on its own.
Diindolylmethane: dosing
There is no official, well-established dose for DIM. Supplement products vary widely in strength, and many add black pepper extract to improve absorption.The safest approach is to follow the directions on the product label and use the lowest amount that seems reasonable.
From our Diindolylmethane monograph — the full record covers uses, side effects and every documented interaction.
About Abemaciclib
What Is Abemaciclib Used For?
Brand name: Verzenio
Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back.
For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.
Other Drugs & Diindolylmethane
Browse every other medication we’ve checked against Diindolylmethane — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
116 interactions
- Estradiol ›
- Hydrochlorothiazide ›
- Conjugated Estrogens ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Metolazone ›
- Spironolactone ›
- Acetazolamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Esterified Estrogens ›
- Estropipate ›
- Indapamide ›
- Mannitol ›
- Methyclothiazide ›
- Torsemide ›
- Ammonium Chloride ›
- Benzthiazide ›
- Bumetanide ›
- Chlorothiazide ›
- Estrogen ›
- Estrone ›
- Ethacrynic Acid ›
- Ethinyl Estradiol ›
- Furosemide ›
- Hydroflumethiazide ›
- Methazolamide ›
- Oestrogen ›
- Polythiazide ›
- Prasterone (prescription Drug) ›
- Quinethazone ›
- Theobromine ›
- Tibolone ›
- Urea ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
- Ethinyl Estradiol, Norgestimate ›
- Ethinyl Estradiol, Desogestrel ›
- Ethinyl Estradiol, Norethindrone, Ferrous Fumarate ›
- Desogestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Ethynodiol Diacetate ›
- Levonorgestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Norgestrel ›
- Hydrochlorothiazide, Triamterene ›
- Amiloride, Hydrochlorothiazide ›
- Hydrochlorothiazide, Methyldopa ›
- Hydrochlorothiazide, Reserpine ›
- Hydrochlorothiazide, Spironolactone ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Atenolol, Chlortalidone ›
- Chlorothiazide, Methyldopa ›
- Drospirenone, Ethinyl Estradiol ›
- Hydralazine, Hydrochlorothiazide, Reserpine ›
- Reserpine, Trichlormethiazide ›
- Bendroflumethiazide, Potassium ›
- Captopril, Hydrochlorothiazide ›
- Chlorthalidone, Clonidine ›
- Conjugated Estrogens, Medroxyprogesterone Acetate ›
- Conjugated Estrogens, Meprobamate ›
- Cyproterone Acetate, Ethinyl Estradiol ›
Showing 60 of 116 moderate interactions — see all 116 on the Diindolylmethane page.
153 interactions
- Theophylline ›
- Naproxen ›
- Propranolol ›
- Verapamil ›
- Acetaminophen ›
- Diazepam ›
- Lofepramine ›
- Nortriptyline ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Cyclobenzaprine ›
- Desipramine ›
- Riluzole ›
- Warfarin Sodium ›
- Asenapine ›
- Caffeine (prescription Drug) ›
- Clomipramine ›
- Clozapine ›
- Flutamide ›
- Imipramine ›
- Propafenone ›
- Ropinirole ›
- Tasimelteon ›
- Tizanidine ›
- Zileuton ›
- Agomelatine ›
- Amitriptyline ›
- Anagrelide ›
- Bendamustine Hydrochloride ›
- Chlordiazepoxide ›
- Clopidogrel ›
- Enasidenib ›
- Etonogestrel ›
- Fenfluamine ›
- Fezolinetant ›
- Fluvoxamine ›
- Grepafloxacin ›
- Haloperidol ›
- Levobupivacaine ›
- Mexiletine ›
- Mirtazapine ›
- Naproxen Sodium ›
- Olanzapine ›
- Ondansetron ›
- Paracetamol ›
- Pentazocine ›
- Perampanel ›
- Pirfenidone ›
- Pomalidomide ›
- Propranolol Hydrochloride ›
- Ramelteon ›
- Rasagiline ›
- Ropivacaine ›
- Tacrine ›
- Tipranavir ›
- Triclabendazole ›
- Warfarin ›
- Acetaminophen, Hydrocodone ›
- Acetaminophen, Butalbital ›
- Acetaminophen, Pseudoephedrine ›
Showing 60 of 153 minor interactions — see all 153 on the Diindolylmethane page.
No interaction 2,560 drugs checked — show the list
We also checked Diindolylmethane against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Prednisone ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
Showing the 60 most looked-up of 2,560 medications checked with no known interaction — see the full Diindolylmethane list.
Diindolylmethane References
The 14 references that drive our Diindolylmethane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
- Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
- Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
- Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
- Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
- Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
- Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
- Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
- Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
- Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
- Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
- Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
- Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
- Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Diindolylmethane and Abemaciclib Together: Common Questions
Is it safe to take Diindolylmethane with Abemaciclib?
Do Diindolylmethane and Abemaciclib have any of the same side effects?
Are Diindolylmethane and Abemaciclib used for the same thing?
How was the Diindolylmethane and Abemaciclib combination checked?
Does Diindolylmethane interact with any other medications?
Does Abemaciclib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.