Drug & supplement interaction

Dusty Miller + Methyclothiazide

Methyclothiazide brand names: Enduron, Aquatensen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Dusty Miller and Methyclothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dusty Miller and Methyclothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methyclothiazide and Dusty Miller in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dusty Miller safety at a glance

Dusty Miller overall Avoid It can contain liver-toxic pyrrolizidine alkaloids and is not recommended for internal or homemade use.
Pregnancy Likely Unsafe When used orally. Dusty miller preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insuf... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in dusty miller are excreted in milk. There is insufficient reliable information availabl... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methyclothiazide and Dusty Miller? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methyclothiazide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methyclothiazide is filed under 6 classifications — including thiazide diuretics, diuretic drugs, antihypertensive drugs. Dusty Miller has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Methyclothiazide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dusty Miller Does Interact With Other Medications

Dusty Miller has 87 moderate known drug interactions in our database — Methyclothiazide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Methyclothiazide)
Taking anything else?

Check Another of Your Medications Against Dusty Miller

Covers the 2,830 medications we’ve checked against Dusty Miller. Pick one to open its full report.

What to actually watch for

What Dusty Miller Itself Has Been Linked To

This is not an interaction — nothing below involves Methyclothiazide. It is the side-effect record for Dusty Miller on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dusty Miller, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    “Orally, the major concern with dusty miller use is its pyrrolizidine alkaloid (PA) content. These constituents can cause lung damage with pulmonary-arterial hypertension.”

    Dusty Miller · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  • Liver problems Worth acting on Additional detail

    “Orally, the major concern with dusty miller use is its pyrrolizidine alkaloid (PA) content. These constituents can cause liver injury. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Subacute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days;”

    Dusty Miller · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 12386. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
    2. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    3. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    4. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  • Diarrhea / Vomiting Additional detail

    Recorded for Dusty Miller in the same Natural Medicines adverse-effect record shown under Liver problems above.

Everything above comes from the Natural Medicines adverse-effect record for Dusty Miller — expand a row for the licensed statement it rests on. We haven’t matched Methyclothiazide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Methyclothiazide.

Special populations

Dusty Miller in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Dusty miller preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of dusty miller products that do not contain hepatotoxic PAs when used during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in dusty miller are excreted in milk. There is insufficient reliable information available about the safety of dusty miller products that do not contain hepatotoxic PAs when used during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methyclothiazide

This page covers Dusty Miller only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyclothiazide page lists 227 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 192 moderate · 25 minor.

Open the Methyclothiazide interaction page

How much people look this up

Where Dusty Miller and Methyclothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dusty Miller
Top half

#613 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyclothiazide
Steady interest

#1,511 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dusty Miller reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dusty Miller and Methyclothiazide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dusty Miller

What is Dusty Miller?

  • Cataracts (traditional eye use)
  • Eye irritation and inflammation
  • Wound healing (folk use)
  • Menstrual complaints (folk use)

Dusty Miller is a silvery ornamental plant that has been used in folk medicine, mainly as an eye remedy for cataracts and irritation. There is no reliable scientific evidence that it works, and the plant contains compounds (pyrrolizidine alkaloids) that can be toxic, so it is not considered safe for self-treatment. Talk to a pharmacist or doctor before using any product made from it.

Jacobaea maritima · Asteraceae · Leaves and flowering tops; historically the plant juice · Traditional eye drops/eyewash, homeopathic preparations, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Dusty Miller is a good idea for someone in your situation. Here is what our Dusty Miller record says about it on its own.

Dusty Miller: dosing

There is no established or safe dose for Dusty Miller. Because the plant can be toxic and has no proven medical benefit, no reliable dosing guidelines exist for any form.We do not recommend self-treating with this plant.

From our Dusty Miller monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dusty Miller monograph & all interactions
Medication

About Methyclothiazide

What Is Methyclothiazide Used For?

Brand names: Enduron, Aquatensen

  • Methyclothiazide is used to treat high blood pressure. Methyclothiazide is also used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Methyclothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

  • High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

See full Methyclothiazide drug information
Keep checking

Other Drugs & Dusty Miller

Browse every other medication we’ve checked against Dusty Miller — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Dusty Miller page.

No interaction 2,742 drugs checked — show the list

We also checked Dusty Miller against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Dusty Miller list.

See the full Dusty Miller interactions page
See every supplement checked against Methyclothiazide, ranked by severity
Evidence & sources

Dusty Miller References

The 5 references that drive our Dusty Miller monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dusty Miller and Methyclothiazide Together: Common Questions

Is it safe to take Dusty Miller with Methyclothiazide?
We do not list a known interaction between Dusty Miller and Methyclothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Dusty Miller and Methyclothiazide combination checked?
Interactions in our licensed database are recorded against drug classes. Methyclothiazide is filed under 6 classifications, and Dusty Miller has documented interactions with 1 drug class — none of Methyclothiazide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dusty Miller interact with any other medications?
Yes. Dusty Miller has 87 documented drug interactions in our database — Methyclothiazide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methyclothiazide interact with any supplements?
Yes. Methyclothiazide has documented interactions with 227 supplements in our database — Dusty Miller is not one of them. The Methyclothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dusty Miller monograph Uses, safety profile, and every drug interaction in one place Methyclothiazide drug information The full plain-English guide to this medication Methyclothiazide supplement interactions Every supplement checked against Methyclothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methyclothiazide and Dusty Miller?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.