Drug & supplement interaction

Evening Primrose + Loteprednol Etabonate

Loteprednol Etabonate brand names: Inveltys, Lotemax SM, Eysuvis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Evening Primrose and Loteprednol Etabonate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Evening Primrose and Loteprednol Etabonate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Loteprednol Etabonate and Evening Primrose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Evening Primrose safety at a glance

Evening Primrose overall Use caution Generally well tolerated short-term, but quality evidence and long-term safety data are limited.
Pregnancy Possibly Safe When evening primrose oil is used orally and appropriately. In small studies of evening primrose oil for pre-eclampsia, 4 grams has been used orally daily for u... Read the full pregnancy detail
Breastfeeding Possibly Safe When evening primrose oil is used orally. Supplementation with evening primrose oil during lactation results in the secretion of high levels of the constituent... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Loteprednol Etabonate and Evening Primrose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Evening Primrose Does Interact With Other Medications

Evening Primrose has 148 moderate, 85 minor known drug interactions in our database — Loteprednol Etabonate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 148 Minor 85 No known interaction 2,597 (incl. Loteprednol Etabonate)
Taking anything else?

Check Another of Your Medications Against Evening Primrose

Covers the 2,830 medications we’ve checked against Evening Primrose. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Evening Primrose and Loteprednol Etabonate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 5.3% of FDA reports for Loteprednol Etabonate Additional detail

    Evening Primrose

    “Cases of dizziness and headache have been reported with evening primrose oil when used orally.

    There is a report of seizures in a patient taking evening primrose oil and receiving anesthesia; however, the patient was also taking other drugs and it is therefore unclear if evening primrose was the cause.”

    Evening Primrose · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 9794. Cheung KL. Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia. Aust N Z J Surg 1999;69:492-4..
    2. 88184. Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet 2013;288(5):1075-9. PubMed
    3. 613. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
    4. 21013. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
    5. 21010. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
    6. 88187. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

    Loteprednol Etabonate

    Listed in the ADVERSE REACTIONS section of the FDA label for Loteprednol Etabonate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Evening Primrose but not commonly for Loteprednol Etabonate: stomach pain, a change in taste, bloating or gas and bleeding or bruising.

Effects for Loteprednol Etabonate come from the ADVERSE REACTIONS section of its FDA label; effects for Evening Primrose come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,898 voluntary FDA FAERS reports for Loteprednol Etabonate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Evening Primrose in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When evening primrose oil is used orally and appropriately. In small studies of evening primrose oil for pre-eclampsia, 4 grams has been used orally daily for up to 10 weeks during pregnancy with apparent safety. ...when evening primrose oil is used orally or intravaginally to improve cervical ripening. Evening primrose oil has been used safely during the last 1-3 weeks of pregnancy to improve cervical ripening. Intravaginally, evening primrose oil 500-1000 mg as either a single dose or administered daily starting at week 38 until pregnancy has been used with apparent safety for this purpose. Orally, evening primrose oil 1500-4500 mg in divided doses daily for 1-3 weeks has been used with apparent safety for this purpose, although one study found 5 cases of meconium-stained amniotic fluid. Some studies report that improvement was lacking and there was a trend toward prolonged labor, prolonged rupture of membranes, increased rates of arrest of descent, and increased oxytocin requirements. Intravaginally, evening primrose oil, 1000 mg every 4 hours up to 5 times or 2000 mg as a single dose, has been used as an adjunct to misoprostol for a medication abortion with apparent safety for this purpose. Evening primrose oil has also been linked to a case report of petechiae and ecchymoses in a newborn infant whose mother took a total of 6.5 grams during the week before giving birth; use with caution, especially in high doses.

Lactation Possibly Safe

When evening primrose oil is used orally. Supplementation with evening primrose oil during lactation results in the secretion of high levels of the constituent gamma linolenic acid into breast milk; however, this fatty acid is normally present in significant amounts in breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Evening Primrose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 98 real supplement products containing Evening Primrose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Evening Primrose. Even though Evening Primrose itself has no known interaction with Loteprednol Etabonate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Evening Primrose and Loteprednol Etabonate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Evening Primrose
Top half

#467 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Loteprednol Etabonate
Steady interest

#2,457 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Evening Primrose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Evening Primrose and Loteprednol Etabonate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Evening Primrose

What is Evening Primrose?

Evening Primrose
  • Eczema and skin health
  • PMS symptoms
  • Breast pain (mastalgia)
  • Menopause symptoms
  • Inflammation
  • Diabetic nerve pain

Evening primrose oil is a seed oil rich in gamma-linolenic acid (GLA), an omega-6 fatty acid, that is popularly used for skin conditions, PMS, and breast pain. The evidence behind most of these uses is mixed or weak, and it is not proven to be a reliable treatment for any condition. It is generally well tolerated for short-term use, but talk to your pharmacist or doctor before starting it, especially if you are pregnant or have a bleeding disorder.

Oenothera biennis · Onagraceae · Seed oil · Capsules, softgels, oil, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Evening Primrose is a good idea for someone in your situation. Here is what our Evening Primrose record says about it on its own.

Evening Primrose: dosing

There is no official, well-established standard dose of evening primrose oil. Do not assume that taking more will give a better result, and avoid using it long-term without medical guidance.

From our Evening Primrose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Evening Primrose monograph & all interactions
Medication

About Loteprednol Ophthalmic

What Is Loteprednol Ophthalmic Used For?

Brand names: Inveltys, Lotemax SM, Eysuvis

Loteprednol ophthalmic suspension is used to treat steroid-responsive inflammatory conditions of the eye, including allergic conjunctivitis, iritis (inflammation inside the eye), cyclitis, superficial punctate keratitis, herpes zoster keratitis, acne rosacea affecting the eye, and certain types of infectious conjunctivitis — when reducing swelling and inflammation is important enough to accept the risks of steroid use.

Loteprednol ophthalmic suspension is also used to treat inflammation after eye surgery. Eysuvis (loteprednol etabonate ophthalmic suspension) is specifically indicated for short-term use of up to two weeks for these inflammatory conditions.

Most-Reported Side Effects for Loteprednol Etabonate

From FAERS, the FDA’s public side-effect reporting system (5,898 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Eye pain 775 reports
Eye irritation 672 reports
Vision blurred 443 reports
Ocular hyperaemia 404 reports
Headache 312 reports
See full Loteprednol Ophthalmic drug information
Keep checking

Other Drugs & Evening Primrose

Browse every other medication we’ve checked against Evening Primrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
148Moderate
85Minor
2,596No known interaction
148 Moderate 85 Minor 2,596 No interaction
Moderate

148 interactions

Showing 60 of 148 moderate interactions — see all 148 on the Evening Primrose page.

Minor

85 interactions

Showing 60 of 85 minor interactions — see all 85 on the Evening Primrose page.

No interaction 2,596 drugs checked — show the list

We also checked Evening Primrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,596 medications checked with no known interaction — see the full Evening Primrose list.

See the full Evening Primrose interactions page
See every supplement checked against Loteprednol Etabonate, ranked by severity
Evidence & sources

Evening Primrose References

The 33 references that drive our Evening Primrose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  2. Laivuori H, Hovatta O, Viinikka L, et al. Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. Prostaglandins Leukot Essent Fatty Acids 1993;49:691-4. PubMed
  3. Dove D, Johnson P. Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women (abstract). J Nurse Midwifery 1999;44:320-4. PubMed
  4. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  5. Cant A, Shay J, Horrobin DF. The effect of maternal supplementation with linoleic and gamma- linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. J Nutr Sci Vitaminol (Tokyo) 1991;37:573-9. PubMed
  6. Keen H, Payan J, Allawi J, et al. Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. Diabetes Care 1993;16:8-15.
  7. Blommers J, de Lange-De Klerk ES, Kuik DJ, et al. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Am J Obstet Gynecol 2002;187:1389-94.. DOI
  8. Cheung KL. Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia. Aust N Z J Surg 1999;69:492-4..
  9. Das UN. The lipids that matter from infant nutrition to insulin resistance. Prostaglandins Leukot Essent Fatty Acids 2002;67:1-12. PubMed
  10. Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr 2008;152:140, 140.e1. PubMed
  11. Ty-Torredes KA. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. Am J Obstet Gynecol. 2006;195(6 Suppl 1):S30.
  12. Moodley J and Norman RJ. Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. Prostaglandins Leukot Essent Fatty Acids 1989;37(3):145-147. PubMed
  13. Tong M. [Treatment of hyperlipemia with evening primrose oil capsules]. Zhong Xi Yi Jie He Za Zhi. 1988;8:469-71, 452-3.
  14. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  15. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Evening Primrose and Loteprednol Etabonate Together: Common Questions

Is it safe to take Evening Primrose with Loteprednol Etabonate?
We do not list a known interaction between Evening Primrose and Loteprednol Etabonate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Evening Primrose and Loteprednol Etabonate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Evening Primrose interact with any other medications?
Yes. Evening Primrose has 233 documented drug interactions in our database — Loteprednol Etabonate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Evening Primrose monograph Uses, safety profile, and every drug interaction in one place Loteprednol Ophthalmic drug information The full plain-English guide to this medication Loteprednol Etabonate supplement interactions Every supplement checked against Loteprednol Etabonate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 33 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.