Drug & supplement interaction

Hibiscus Sabdariffa + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hibiscus Sabdariffa and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hibiscus Sabdariffa and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Hibiscus Sabdariffa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hibiscus Sabdariffa safety at a glance

Hibiscus Sabdariff... overall Use caution Generally well tolerated as a tea, but concentrated extracts and high doses warrant caution.
Pregnancy Possibly Unsafe When used orally. Hibiscus sabdariffa is thought to be a menstrual stimulant, and might have abortifacient effects. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally in large amounts. Animal research found that administering large doses of Hibiscus sabdariffa during lactation decreases food and water intake... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Hibiscus Sabdariffa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefaclor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefaclor is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Hibiscus Sabdariffa has documented interactions with 16 drug classes — the most serious being chloroquine (aralen) (major), antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Cefaclor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hibiscus Sabdariffa Does Interact With Other Medications

Hibiscus Sabdariffa has 2 major, 266 moderate, 819 minor known drug interactions in our database — Cefaclor isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 266 Minor 819 No known interaction 1,743 (incl. Cefaclor)
Taking anything else?

Check Another of Your Medications Against Hibiscus Sabdariffa

Covers the 2,830 medications we’ve checked against Hibiscus Sabdariffa. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hibiscus Sabdariffa and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tremor or shakiness / Headache Additional detail

    Hibiscus Sabdariffa

    “Orally, taking Hibiscus sabdariffa calyx extract 3 grams daily has been associated with one report of tremor and headache in one clinical trial.”

    Hibiscus Sabdariffa · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 55000. Hernandez-Perez, F. and Herrera-Arellano, A. [Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial]. Rev.Med Inst.Mex.Seguro.Soc. 2011;49(5):469-480.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Bloating or gas / Constipation / Stomach pain / Nausea Additional detail

    Hibiscus Sabdariffa

    “Orally, taking a specific Hibiscus sabdariffa leaf extract (Green Chem) 1 gram daily has been associated with reports of transient gastrointestinal symptoms such as abdominal distention, flatulence, and epigastric pain in one clinical trial. However, the overall rate of these adverse effects was similar to placebo.”

    Hibiscus Sabdariffa · Natural Medicines adverse-effect record, reported in constipation.

    4 sources cited
    1. 17415. Kuriyan R, Kumar DR, Rajendran R, Kurpad AV. An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial. BMC Complement Altern Med 2010;10:27. PubMed
    2. 55000. Hernandez-Perez, F. and Herrera-Arellano, A. [Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial]. Rev.Med Inst.Mex.Seguro.Soc. 2011;49(5):469-480.
    3. 93816. Sabzghabaee AM, Ataei E, Kelishadi R, Ghannadi A, Soltani R, Badri S, Shirani S. Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial. Mater Sociomed. 2013;25(2):76-9. PubMed
    4. 101733. Al-Anbaki M, Nogueira RC, Cavin AL, et al. Treating uncontrolled hypertension with Hibiscus sabdariffa when standard treatment is insufficient: Pilot intervention. J Altern Complement Med. 2019;25(12):1200-1205.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Reported for Hibiscus Sabdariffa but not commonly for Cefaclor: ringing in the ears.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Hibiscus Sabdariffa come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hibiscus Sabdariffa in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Hibiscus sabdariffa is thought to be a menstrual stimulant, and might have abortifacient effects.

Lactation Possibly Unsafe

When used orally in large amounts. Animal research found that administering large doses of Hibiscus sabdariffa during lactation decreases food and water intake during pregnancy and delays puberty in offspring; however, this has not been assessed in humans.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cefaclor Products Have a Food Rule — Hibiscus Sabdariffa Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Hibiscus Sabdariffa on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Hibiscus Sabdariffa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

How much people look this up

Where Hibiscus Sabdariffa and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hibiscus Sabdariffa
Top half

#413 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#197 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hibiscus Sabdariffa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hibiscus Sabdariffa and Cefaclor records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hibiscus Sabdariffa

What is Hibiscus Sabdariffa?

Hibiscus Sabdariffa
  • High blood pressure
  • Heart and cholesterol health
  • Digestive upset
  • Antioxidant support
  • Fever and general wellness

Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood pressure. Evidence for other uses is limited, and while hibiscus tea is generally well tolerated in food amounts, concentrated supplements should be used cautiously and avoided in pregnancy. Talk to your pharmacist or doctor before using it for a medical condition.

Hibiscus sabdariffa · Malvaceae · Dried flowers (calyces), and sometimes leaves · Tea, dried calyces, capsules, extracts, juices/beverages

An interaction check asks whether these two react with each other — it does not ask whether Hibiscus Sabdariffa is a good idea for someone in your situation. Here is what our Hibiscus Sabdariffa record says about it on its own.

Hibiscus Sabdariffa: dosing

There is no official standardized dose for hibiscus. In studies, people have used it as a tea made from dried calyces or as standardized extracts, but the amounts vary widely between products and studies.If you use a supplement, follow the directions on the product label.

From our Hibiscus Sabdariffa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hibiscus Sabdariffa monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. Cefaclor capsules and oral suspension are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

Cefaclor extended-release tablets are approved for a narrower set of uses in adults: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin and skin structure infections. Not all formulations are approved for the same conditions, so the form matters.

See full Cefaclor drug information
Keep checking

Other Drugs & Hibiscus Sabdariffa

Browse every other medication we’ve checked against Hibiscus Sabdariffa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
266Moderate
819Minor
1,742No known interaction
2 Major 266 Moderate 819 Minor 1,742 No interaction
Major

2 interactions

Moderate

266 interactions

Showing 60 of 266 moderate interactions — see all 266 on the Hibiscus Sabdariffa page.

Minor

819 interactions

Showing 60 of 819 minor interactions — see all 819 on the Hibiscus Sabdariffa page.

No interaction 1,742 drugs checked — show the list

We also checked Hibiscus Sabdariffa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,742 medications checked with no known interaction — see the full Hibiscus Sabdariffa list.

See the full Hibiscus Sabdariffa interactions page
See every supplement checked against Cefaclor, ranked by severity
Evidence & sources

Hibiscus Sabdariffa References

The 19 references that drive our Hibiscus Sabdariffa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Kolawole JA, Maduenyi A. Effect of zobo drink (Hibiscus sabdariffa water extract) on pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet 2004;29:25-9.
  3. McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus Sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr 2010;140:298-303. PubMed
  4. Kuriyan R, Kumar DR, Rajendran R, Kurpad AV. An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial. BMC Complement Altern Med 2010;10:27. PubMed
  5. Haji, Faraji M. and Haji, Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J.Ethnopharmacol. 1999;65(3):231-236. PubMed
  6. Mozaffari-Khosravi, H., Jalali-Khanabadi, B. A., Afkhami-Ardekani, M., Fatehi, F., and Noori-Shadkam, M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum.Hypertens 2009;23(1):48-54. PubMed
  7. Gurrola-Diaz, C. M., Garcia-Lopez, P. M., Sanchez-Enriquez, S., Troyo-Sanroman, R., Andrade-Gonzalez, I., and Gomez-Leyva, J. F. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metaboli
  8. Hernandez-Perez, F. and Herrera-Arellano, A. [Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial]. Rev.Med Inst.Mex.Seguro.Soc. 2011;49(5):469-480.
  9. Mahmoud, B. M., Ali, H. M., Homeida, M. M., and Bennett, J. L. Significant reduction in chloroquine bioavailability following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon. J.Antimicrob.Chemother. 1994;33(5):1005-1009.
  10. Iyare EE, Adegoke OA. Maternal consumption of an aqueous extract of Hibiscus sabdariffa during lactation accelerates postnatal weight and delays onset of puberty in female offspring. Niger J Physiol Sci. 2008 Jun-Dec;23(1-2):89-94. PubMed
  11. Johnson SS, Oyelola FT, Ari T, Juho H. In vitro inhibitory activities of the extract of Hibiscus sabdariffa L. (family Malvaceae) on selected cytochrome P450 isoforms. Afr J Tradit Complement Altern Med. 2013 Apr 12;10(3):533-40.
  12. Sabzghabaee AM, Ataei E, Kelishadi R, Ghannadi A, Soltani R, Badri S, Shirani S. Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial. Mater Sociomed. 2013;25(2):76-9. PubMed
  13. Showande SJ, Adegbolagun OM, Igbinoba SI, Fakeye TO. In vivo pharmacodynamic and pharmacokinetic interactions of Hibiscus sabdariffa calyces extracts with simvastatin. J Clin Pharm Ther. 2017;42(6):695-703.
  14. Fakeye TO, Adegoke AO, Omoyeni OC, Famakinde AA. Effects of water extract of Hibiscus sabdariffa, Linn (Malvaceae) 'Roselle' on excretion of a diclofenac formulation. Phytother Res. 2007;21(1):96-8.
  15. Al-Anbaki M, Nogueira RC, Cavin AL, et al. Treating uncontrolled hypertension with Hibiscus sabdariffa when standard treatment is insufficient: Pilot intervention. J Altern Complement Med. 2019;25(12):1200-1205.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hibiscus Sabdariffa and Cefaclor Together: Common Questions

Is it safe to take Hibiscus Sabdariffa with Cefaclor?
We do not list a known interaction between Hibiscus Sabdariffa and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hibiscus Sabdariffa and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Hibiscus Sabdariffa and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Hibiscus Sabdariffa on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Hibiscus Sabdariffa and Cefaclor combination checked?
Interactions in our licensed database are recorded against drug classes. Cefaclor is filed under 6 classifications, and Hibiscus Sabdariffa has documented interactions with 16 drug classes — none of Cefaclor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hibiscus Sabdariffa interact with any other medications?
Yes. Hibiscus Sabdariffa has 1,087 documented drug interactions in our database — Cefaclor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Hibiscus Sabdariffa is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hibiscus Sabdariffa monograph Uses, safety profile, and every drug interaction in one place Cefaclor drug information The full plain-English guide to this medication Cefaclor supplement interactions Every supplement checked against Cefaclor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 19 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.