Drug & supplement interaction

Jiaogulan + Psyllium (OTC drug)

Psyllium (OTC drug) brand name: Metamucil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Jiaogulan and Psyllium (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Jiaogulan and Psyllium (OTC drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Psyllium (OTC drug) and Jiaogulan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jiaogulan safety at a glance

Jiaogulan overall Use caution Generally well tolerated in tea or supplement form for short periods, but long-term safety is not well studied.
Pregnancy Possibly Unsafe When used orally. Ginsenoside Rb1, which is identical to the jiaogulan constituent gypenoside 3, has teratogenic effects in animal models; avoid using. Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding because there is not enough safety information.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Psyllium (OTC drug) and Jiaogulan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Psyllium (OTC drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Psyllium (OTC drug) is filed under a single classification — oral drugs. Jiaogulan has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Psyllium (OTC drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jiaogulan Does Interact With Other Medications

Jiaogulan has 327 moderate known drug interactions in our database — Psyllium (OTC drug) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Psyllium (OTC drug))
Taking anything else?

Check Another of Your Medications Against Jiaogulan

Covers the 2,830 medications we’ve checked against Jiaogulan. Pick one to open its full report.

What to actually watch for

What Jiaogulan Itself Has Been Linked To

This is not an interaction — nothing below involves Psyllium (OTC drug). It is the side-effect record for Jiaogulan on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Jiaogulan, this list is the first place to look.

  • Dry mouth Additional detail

    “Orally, jiaogulan may cause diarrhea and nausea (6,106651). Dry mouth has also been reported with oral jiaogulan use.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 106651. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.
  • Trouble sleeping / Dizziness Additional detail

    “Orally, jiaogulan may cause dizziness and insomnia.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 106651. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.
  • Diarrhea / Nausea Additional detail

    “Orally, jiaogulan seems to be well tolerated when used for up to 4 months.

    Most Common Adverse Effects:

    Orally: Diarrhea and nausea.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in diarrhea.

Everything above comes from the Natural Medicines adverse-effect record for Jiaogulan — expand a row for the licensed statement it rests on. We haven’t matched Psyllium (OTC drug) to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Psyllium (OTC drug).

Special populations

Jiaogulan in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Ginsenoside Rb1, which is identical to the jiaogulan constituent gypenoside 3, has teratogenic effects in animal models; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Jiaogulan or Psyllium (OTC drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jiaogulan or Psyllium (OTC drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Psyllium (OTC drug)

This page covers Jiaogulan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Psyllium (OTC drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Psyllium (OTC drug) page

“Activated charcoal tops the psyllium (Metamucil) list and is the one entry rated major. Charcoal binds many medicines in the gut and can cut how much of them reaches the body, so pairing it with anything you take by mouth deserves real caution, and I would read that entry before the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Psyllium (OTC drug) interaction page

One more smart check

Taking Jiaogulan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 452 real supplement products containing Jiaogulan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jiaogulan. Even though Jiaogulan itself has no known interaction with Psyllium (OTC drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jiaogulan and Psyllium (OTC drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jiaogulan
Top 25%

#291 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Psyllium (OTC drug)
Top half

#875 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jiaogulan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Jiaogulan and Psyllium (OTC drug) records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jiaogulan

What is Jiaogulan?

Jiaogulan
  • Fatigue and stress (adaptogen)
  • Blood sugar support
  • High blood pressure
  • High cholesterol
  • Immune and general wellness

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some uses like metabolism and blood pressure, but the overall evidence is still limited. Talk with your pharmacist or doctor before starting it, especially if you have a health condition or take medication.

Gynostemma pentaphyllum · Cucurbitaceae · Leaves and aerial parts · Tea, capsules, tablets, liquid extracts, powders

An interaction check asks whether these two react with each other — it does not ask whether Jiaogulan is a good idea for someone in your situation. Here is what our Jiaogulan record says about it on its own.

Jiaogulan: dosing

There is no official, standardized dose of jiaogulan. The right amount can vary depending on the product, its strength, and whether it is a tea, capsule, or extract.The safest approach is to follow the directions on the product label and not to exceed the recommended amount.

From our Jiaogulan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jiaogulan monograph & all interactions
Medication

About Psyllium

What Is Psyllium Used For?

Brand name: Metamucil

Psyllium is used to treat occasional constipation and help restore regularity. It is available under many brand names — including Careone, Best Choice, Premier Value Fiber, fiber laxative, meijer fiber laxative, Publix, Best Choice Fiber Therapy, Daily Fiber, Dr. Fibra, Lidl Orange Smooth Fiber Powder, and meijer fiber therapy — all for this same purpose.

Most products note that psyllium generally produces a bowel movement within 12 to 72 hours of taking a dose.

See full Psyllium drug information
Keep checking

Other Drugs & Jiaogulan

Browse every other medication we’ve checked against Jiaogulan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Jiaogulan page.

No interaction 2,502 drugs checked — show the list

We also checked Jiaogulan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Jiaogulan list.

See the full Jiaogulan interactions page
See every supplement checked against Psyllium (OTC drug), ranked by severity
Evidence & sources

Jiaogulan References

The 8 references that drive our Jiaogulan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jiaogulan and Psyllium (OTC drug) Together: Common Questions

Is it safe to take Jiaogulan with Psyllium (OTC drug)?
We do not list a known interaction between Jiaogulan and Psyllium (OTC drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Jiaogulan and Psyllium (OTC drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Psyllium (OTC drug) is filed under 1 classification, and Jiaogulan has documented interactions with 3 drug classes — none of Psyllium (OTC drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jiaogulan interact with any other medications?
Yes. Jiaogulan has 327 documented drug interactions in our database — Psyllium (OTC drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Psyllium (OTC drug) interact with any supplements?
Yes. Psyllium (OTC drug) has documented interactions with 17 supplements in our database — Jiaogulan is not one of them. The Psyllium (OTC drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jiaogulan monograph Uses, safety profile, and every drug interaction in one place Psyllium drug information The full plain-English guide to this medication Psyllium (OTC drug) supplement interactions Every supplement checked against Psyllium (OTC drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Psyllium (OTC drug) and Jiaogulan?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.