Drug & supplement interaction

Securinega Suffruticosa + Pentoxifylline

Pentoxifylline brand name: Trental.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Securinega Suffruticosa and Pentoxifylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pentoxifylline states a food rule worth keeping to.

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Interaction report

Securinega Suffruticosa and Pentoxifylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentoxifylline and Securinega Suffruticosa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Securinega Suffruticosa safety at a glance

Securinega Suffrut... overall Avoid It contains potent, potentially toxic alkaloids and has no established safe supplement dose.
Pregnancy Avoid No safety data; its stimulant alkaloids make it unsafe during pregnancy.
Breastfeeding Avoid No safety data and potential transfer of toxic alkaloids; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentoxifylline and Securinega Suffruticosa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pentoxifylline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentoxifylline is filed under 2 classifications — anticoagulant/antiplatelet drugs, oral drugs. Securinega Suffruticosa has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Pentoxifylline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Securinega Suffruticosa Does Interact With Other Medications

Securinega Suffruticosa has 172 moderate known drug interactions in our database — Pentoxifylline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Pentoxifylline)
Taking anything else?

Check Another of Your Medications Against Securinega Suffruticosa

Covers the 2,830 medications we’ve checked against Securinega Suffruticosa. Pick one to open its full report.

What to actually watch for

What Pentoxifylline’s Own FDA Label Lists

This is not an interaction — none of it involves Securinega Suffruticosa. These are the most notable effects listed in the ADVERSE REACTIONS section of Pentoxifylline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on mentioned in 9.4% of FDA reports for Pentoxifylline
  • Yellowing of the skin or eyes Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on

Showing the 10 most notable of 39 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pentoxifylline. Read the label on DailyMed › Where a percentage is shown, it is the share of 4,245 voluntary FDA FAERS reports for Pentoxifylline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Securinega Suffruticosa’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Securinega Suffruticosa side to compare — that is a limit of the record, not a statement that Securinega Suffruticosa has no side effects.

How to take them

Some Pentoxifylline Products Have a Food Rule — Securinega Suffruticosa Should Not Break It

At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Securinega Suffruticosa on an empty stomach out of habit, keep them separate — and take Pentoxifylline with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pentoxifylline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The usual dosage of pentoxifylline in extended-release tablet form is one tablet (400 mg) three times a day with meals.

From the Dosage and Administration section of the FDA label we read for Pentoxifylline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pentoxifylline

This page covers Securinega Suffruticosa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentoxifylline page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Pentoxifylline page

“Pentoxifylline (Trental) improves blood flow in people with poor leg circulation partly by making platelets less sticky, so treat this list as one to read carefully rather than skim. Of the 218 supplements on file, 202 can also slow clotting, which means adding them stacks bleeding risk on bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Pentoxifylline interaction page

How much people look this up

Where Securinega Suffruticosa and Pentoxifylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Securinega Suffruticosa
Steady interest

#1,051 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pentoxifylline
Top half

#881 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Securinega Suffruticosa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Securinega Suffruticosa and Pentoxifylline records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Securinega Suffruticosa

What is Securinega Suffruticosa?

  • Nerve and muscle weakness
  • Fatigue and low energy
  • Nerve-related conditions in traditional medicine
  • Childhood paralysis (historical traditional use)
  • General tonic

Securinega suffruticosa is a shrub used in traditional East Asian medicine, best known for an alkaloid called securinine that strongly stimulates the nervous system. Because securinine is powerful and can cause seizures and serious toxicity, this plant is not a safe or well-studied dietary supplement, and it should not be used for self-treatment. Talk to a doctor or pharmacist before considering anything containing this plant.

Securinega suffruticosa · Phyllanthaceae · Leaves, twigs, and aerial parts (roots in some traditional preparations) · Dried herb decoction, tinctures, and isolated alkaloid extracts (mainly used in research settings)

An interaction check asks whether these two react with each other — it does not ask whether Securinega Suffruticosa is a good idea for someone in your situation. Here is what our Securinega Suffruticosa record says about it on its own.

Securinega Suffruticosa: dosing

There is no established, standardized safe dose of Securinega suffruticosa for use as a supplement. The plant's alkaloid content can vary, and the active compound securinine has a narrow margin between any effect and toxic effects.Because of these safety concerns, we cannot recommend a specific amount.

From our Securinega Suffruticosa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Securinega Suffruticosa monograph & all interactions
Medication

About Pentoxifylline

What Is Pentoxifylline Used For?

Brand name: Trental

Pentoxifylline Extended-Release Tablets are used to treat intermittent claudication — leg pain, cramping, or fatigue that happens during walking because narrowed arteries aren't delivering enough blood to the muscles. The underlying cause is chronic occlusive arterial disease, a condition where the arteries in the limbs become blocked or narrowed over time.

Pentoxifylline can help improve walking distance and reduce symptoms, but it is not a substitute for procedures that physically open or bypass blocked arteries when those treatments are needed.

Most-Reported Side Effects for Pentoxifylline

From FAERS, the FDA’s public side-effect reporting system (4,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 457 reports
Diarrhea 431 reports
Dyspnea 405 reports
Fall 376 reports
Dizziness 371 reports
See full Pentoxifylline drug information
Keep checking

Other Drugs & Securinega Suffruticosa

Browse every other medication we’ve checked against Securinega Suffruticosa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Securinega Suffruticosa page.

No interaction 2,657 drugs checked — show the list

We also checked Securinega Suffruticosa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Securinega Suffruticosa list.

See the full Securinega Suffruticosa interactions page
See every supplement checked against Pentoxifylline, ranked by severity
Evidence & sources

Securinega Suffruticosa References

The 2 references that drive our Securinega Suffruticosa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Holmes M, Crater AK, Dhudshia B, Thadani AN, Ananvoranich S. Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth. Exp Parasitol. 2011;127(2):370-5. PubMed
  2. Raj D, Luczkiewicz M. Securinega suffruticosa. Fitoterapia. 2008;79(6):419-27. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Securinega Suffruticosa and Pentoxifylline Together: Common Questions

Is it safe to take Securinega Suffruticosa with Pentoxifylline?
We do not list a known interaction between Securinega Suffruticosa and Pentoxifylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Securinega Suffruticosa and Pentoxifylline at the same time of day?
At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Securinega Suffruticosa on an empty stomach out of habit, keep them separate and take Pentoxifylline with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pentoxifylline products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Securinega Suffruticosa and Pentoxifylline combination checked?
Interactions in our licensed database are recorded against drug classes. Pentoxifylline is filed under 2 classifications, and Securinega Suffruticosa has documented interactions with 1 drug class — none of Pentoxifylline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Securinega Suffruticosa interact with any other medications?
Yes. Securinega Suffruticosa has 172 documented drug interactions in our database — Pentoxifylline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pentoxifylline interact with any supplements?
Yes. Pentoxifylline has documented interactions with 218 supplements in our database — Securinega Suffruticosa is not one of them. The Pentoxifylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Securinega Suffruticosa monograph Uses, safety profile, and every drug interaction in one place Pentoxifylline drug information The full plain-English guide to this medication Pentoxifylline supplement interactions Every supplement checked against Pentoxifylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentoxifylline and Securinega Suffruticosa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.