Drug & supplement interaction

Sweet Woodruff + Bendamustine Hydrochloride

Bendamustine Hydrochloride brand name: Bendeka.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sweet Woodruff and Bendamustine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sweet Woodruff and Bendamustine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bendamustine Hydrochloride and Sweet Woodruff in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Woodruff safety at a glance

Sweet Woodruff overall Use caution Generally used in small amounts as a flavoring, but its coumarin content can be harmful in larger or long-term doses.
Pregnancy Avoid Not enough safety data and possible coumarin-related risks, so it is best avoided.
Breastfeeding Avoid Safety is unknown, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bendamustine Hydrochloride and Sweet Woodruff? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bendamustine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bendamustine Hydrochloride is filed under 3 classifications — alkylating agents, cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates. Sweet Woodruff has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Bendamustine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sweet Woodruff Does Interact With Other Medications

Sweet Woodruff has 122 moderate known drug interactions in our database — Bendamustine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Bendamustine Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Sweet Woodruff

Covers the 2,830 medications we’ve checked against Sweet Woodruff. Pick one to open its full report.

What to actually watch for

What Sweet Woodruff Itself Has Been Linked To

This is not an interaction — nothing below involves Bendamustine Hydrochloride. It is the side-effect record for Sweet Woodruff on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Sweet Woodruff, this list is the first place to look.

  • Dizziness Additional detail

    “Orally, sweet woodruff can cause headache, stupor, or dizziness, especially in larger amounts (12,18,76951).”

    Sweet Woodruff · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 76951. Stuart, M. The Encyclopedia of Herbs and Herbalism. 1979.
  • Headache Additional detail

    “Orally, sweet woodruff is generally well tolerated. However, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Headache.

    Serious Adverse Effects (Rare):

    Orally: Liver disease.”

    Sweet Woodruff · Natural Medicines adverse-effect record, reported in cirrhosis.

Everything above comes from the Natural Medicines adverse-effect record for Sweet Woodruff — expand a row for the licensed statement it rests on. We haven’t matched Bendamustine Hydrochloride to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Bendamustine Hydrochloride.

Everything else you take

See Every Supplement That Interacts With Bendamustine Hydrochloride

This page covers Sweet Woodruff only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bendamustine Hydrochloride page lists 86 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Acerola (moderate), Adrafinil (moderate), African Wild Potato (moderate), Alpha-lipoic Acid (moderate) and Ashitaba (moderate).

By severity: 62 moderate · 24 minor.

From our pharmacist’s overview on the Bendamustine Hydrochloride page

“Bendamustine (Bendeka), a chemotherapy used for certain leukemias and lymphomas, carries 86 supplement and herbal interactions on file, and none of them rates major, so this is a watch-and-adjust list rather than an alarm. Nearly all of the entries, about 80, involve the same liver enzyme, CYP1A2, which helps process bendamustine.”

Reviewed by 2 · Jul 18, 2026

Open the Bendamustine Hydrochloride interaction page

One more smart check

Taking Sweet Woodruff as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Sweet Woodruff, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sweet Woodruff. Even though Sweet Woodruff itself has no known interaction with Bendamustine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sweet Woodruff and Bendamustine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Woodruff
Steady interest

#1,069 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bendamustine Hydrochloride
Top 25%

#385 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Woodruff reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Woodruff and Bendamustine Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Woodruff

What is Sweet Woodruff?

Sweet Woodruff
  • Digestive upset
  • Anxiety, restlessness, and sleep
  • Liver and gallbladder complaints
  • Urinary tract problems
  • Respiratory complaints
  • As a flavoring agent

Sweet woodruff is a fragrant European herb traditionally used for digestion, calming, and various other complaints, but solid human evidence for any of these uses is lacking. It contains coumarin, which can be harmful in large amounts, so it should be used only sparingly and avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before using it.

Galium odoratum · Rubiaceae · Above-ground parts (leaves, flowering tops, and stems) · Dried herb, tea, tinctures, and traditional flavoring (for example in some wines and beverages)

An interaction check asks whether these two react with each other — it does not ask whether Sweet Woodruff is a good idea for someone in your situation. Here is what our Sweet Woodruff record says about it on its own.

Sweet Woodruff: dosing

There is no well-established, standardized medicinal dose for sweet woodruff, and good clinical research is lacking. Because of its coumarin content, experts generally recommend keeping any use to small amounts and short periods of time.If you choose to use a product that contains sweet woodruff, follow the directions on the label and do not exceed the recommended amount.

From our Sweet Woodruff monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Woodruff monograph & all interactions
Medication

About Bendamustine Injection

What Is Bendamustine Injection Used For?

Brand name: Bendeka

Bendamustine hydrochloride injection is used to treat adults with chronic lymphocytic leukemia (CLL). It is also used for adults with indolent B-cell non-Hodgkin lymphoma (NHL) — a slow-growing type of blood cancer — when the disease has continued to progress during or within six months of treatment with rituximab or a rituximab-containing regimen.

For CLL, how well bendamustine works compared to other first-line treatments (aside from chlorambucil) has not been fully established.

Most-Reported Side Effects for Bendamustine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (11,906 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 861 reports
Disease progression 572 reports
Rash 556 reports
Febrile neutropenia 535 reports
Neutropenia 501 reports
See full Bendamustine Injection drug information
Keep checking

Other Drugs & Sweet Woodruff

Browse every other medication we’ve checked against Sweet Woodruff — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Sweet Woodruff page.

No interaction 2,707 drugs checked — show the list

We also checked Sweet Woodruff against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Sweet Woodruff list.

See the full Sweet Woodruff interactions page
See every supplement checked against Bendamustine Hydrochloride, ranked by severity
Evidence & sources

Sweet Woodruff References

The 6 references that drive our Sweet Woodruff monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Sulma, T. and Wierzchowska, K. [Studies on the content of coumarin in the herbs of the woodruff (Herba Asperulae odoratae) throughout the vegetative period of the plant.]. Acta Pol.Pharm 1963;20:77-82.
  4. Kovac-Besovic, E. E. and Duric, K. Thin layer chromatography-application in qualitative analysis on presence of coumarins and flavonoids in plant material. Bosn.J Basic Med.Sci. 2003;3(3):19-26. PubMed
  5. Stuart, M. The Encyclopedia of Herbs and Herbalism. 1979.
  6. Kahkeshani N, Farahanikia B, Mahdaviani P, et al. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci 2013;8(3):197-203.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Woodruff and Bendamustine Hydrochloride Together: Common Questions

Is it safe to take Sweet Woodruff with Bendamustine Hydrochloride?
We do not list a known interaction between Sweet Woodruff and Bendamustine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Sweet Woodruff and Bendamustine Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Bendamustine Hydrochloride is filed under 3 classifications, and Sweet Woodruff has documented interactions with 1 drug class — none of Bendamustine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sweet Woodruff interact with any other medications?
Yes. Sweet Woodruff has 122 documented drug interactions in our database — Bendamustine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bendamustine Hydrochloride interact with any supplements?
Yes. Bendamustine Hydrochloride has documented interactions with 86 supplements in our database — Sweet Woodruff is not one of them. The Bendamustine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Woodruff monograph Uses, safety profile, and every drug interaction in one place Bendamustine Injection drug information The full plain-English guide to this medication Bendamustine Hydrochloride supplement interactions Every supplement checked against Bendamustine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bendamustine Hydrochloride and Sweet Woodruff?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.