Drug & supplement interaction

Sweet Woodruff + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sweet Woodruff and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sweet Woodruff and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Sweet Woodruff in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Woodruff safety at a glance

Sweet Woodruff overall Use caution Generally used in small amounts as a flavoring, but its coumarin content can be harmful in larger or long-term doses.
Pregnancy Avoid Not enough safety data and possible coumarin-related risks, so it is best avoided.
Breastfeeding Avoid Safety is unknown, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Sweet Woodruff? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tasimelteon

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tasimelteon is filed under 5 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, cns depressants. Sweet Woodruff has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Tasimelteon’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sweet Woodruff Does Interact With Other Medications

Sweet Woodruff has 122 moderate known drug interactions in our database — Tasimelteon isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Tasimelteon)
Taking anything else?

Check Another of Your Medications Against Sweet Woodruff

Covers the 2,830 medications we’ve checked against Sweet Woodruff. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sweet Woodruff and Tasimelteon May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 6.7% of FDA reports for Tasimelteon Additional detail

    Sweet Woodruff

    “Orally, sweet woodruff can cause headache, stupor, or dizziness, especially in larger amounts (12,18,76951).”

    Sweet Woodruff · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 76951. Stuart, M. The Encyclopedia of Herbs and Herbalism. 1979.

    Tasimelteon

    Listed in the ADVERSE REACTIONS section of the FDA label for Tasimelteon, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Sweet Woodruff but not commonly for Tasimelteon: dizziness.

Effects for Tasimelteon come from the ADVERSE REACTIONS section of its FDA label; effects for Sweet Woodruff come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,765 voluntary FDA FAERS reports for Tasimelteon that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Tasimelteon Products Have a Food Rule — Sweet Woodruff Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Sweet Woodruff included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Sweet Woodruff to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Sweet Woodruff only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

One more smart check

Taking Sweet Woodruff as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Sweet Woodruff, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sweet Woodruff. Even though Sweet Woodruff itself has no known interaction with Tasimelteon, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sweet Woodruff and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Woodruff
Steady interest

#1,164 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#2,199 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Woodruff reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Woodruff and Tasimelteon records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Woodruff

What is Sweet Woodruff?

Sweet Woodruff
  • Digestive upset
  • Anxiety, restlessness, and sleep
  • Liver and gallbladder complaints
  • Urinary tract problems
  • Respiratory complaints
  • As a flavoring agent

Sweet woodruff is a fragrant European herb traditionally used for digestion, calming, and various other complaints, but solid human evidence for any of these uses is lacking. It contains coumarin, which can be harmful in large amounts, so it should be used only sparingly and avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before using it.

Galium odoratum · Rubiaceae · Above-ground parts (leaves, flowering tops, and stems) · Dried herb, tea, tinctures, and traditional flavoring (for example in some wines and beverages)

An interaction check asks whether these two react with each other — it does not ask whether Sweet Woodruff is a good idea for someone in your situation. Here is what our Sweet Woodruff record says about it on its own.

Sweet Woodruff: dosing

There is no well-established, standardized medicinal dose for sweet woodruff, and good clinical research is lacking. Because of its coumarin content, experts generally recommend keeping any use to small amounts and short periods of time.If you choose to use a product that contains sweet woodruff, follow the directions on the label and do not exceed the recommended amount.

From our Sweet Woodruff monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Woodruff monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Sweet Woodruff

Browse every other medication we’ve checked against Sweet Woodruff — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Sweet Woodruff page.

No interaction 2,707 drugs checked — show the list

We also checked Sweet Woodruff against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Sweet Woodruff list.

See the full Sweet Woodruff interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Sweet Woodruff References

The 6 references that drive our Sweet Woodruff monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Sulma, T. and Wierzchowska, K. [Studies on the content of coumarin in the herbs of the woodruff (Herba Asperulae odoratae) throughout the vegetative period of the plant.]. Acta Pol.Pharm 1963;20:77-82.
  4. Kovac-Besovic, E. E. and Duric, K. Thin layer chromatography-application in qualitative analysis on presence of coumarins and flavonoids in plant material. Bosn.J Basic Med.Sci. 2003;3(3):19-26. PubMed
  5. Stuart, M. The Encyclopedia of Herbs and Herbalism. 1979.
  6. Kahkeshani N, Farahanikia B, Mahdaviani P, et al. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci 2013;8(3):197-203.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Woodruff and Tasimelteon Together: Common Questions

Is it safe to take Sweet Woodruff with Tasimelteon?
We do not list a known interaction between Sweet Woodruff and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sweet Woodruff and Tasimelteon have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Sweet Woodruff and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Sweet Woodruff to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Sweet Woodruff and Tasimelteon combination checked?
Interactions in our licensed database are recorded against drug classes. Tasimelteon is filed under 5 classifications, and Sweet Woodruff has documented interactions with 1 drug class — none of Tasimelteon's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sweet Woodruff interact with any other medications?
Yes. Sweet Woodruff has 122 documented drug interactions in our database — Tasimelteon is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Sweet Woodruff is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Woodruff monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Sweet Woodruff?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.