Drug & supplement interaction

Yerba Mansa + Zuclopenthizol

Zuclopenthizol brand name: Clopixol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Yerba Mansa has a moderate interaction with Zuclopenthizol. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Yerba Mansa and Zuclopenthizol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Zuclopenthizol

Zuclopenthizol falls under CNS DEPRESSANTS — the group Yerba Mansa interacts with.

Theoretically, concomitant use might cause additive or prolonged sedative effects.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Zuclopenthixol (Clopixol) is an antipsychotic that already tends to make people drowsy and relaxed. The concern with yerba mansa is that it may add its own mild calming effect on top of that, so the two together could leave you feeling more sedated than usual. Think extra sleepiness, slowed thinking, dizziness, or feeling unsteady on your feet.

I want to be honest with you though, this is a theoretical concern based on how these things work, not something proven in people. Yerba mansa simply hasn't been well studied. Still, since heavy sedation can be risky, it's worth a quick chat with your pharmacist or doctor before combining them, and don't change your Clopixol on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Yerba Mansa Also Interacts With Other Medications

Yerba Mansa has 247 moderate known drug interactions in our database — the Zuclopenthizol one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Zuclopenthizol)
Taking anything else?

Check Another of Your Medications Against Yerba Mansa

Covers the 2,830 medications we’ve checked against Yerba Mansa. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Zuclopenthizol

This page covers Yerba Mansa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zuclopenthizol page lists 205 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 15 major · 178 moderate · 12 minor.

From our pharmacist’s overview on the Zuclopenthizol page

“Zuclopenthizol (Clopixol) is a sedating antipsychotic, and most of the 205 supplement interactions on record push in that same direction. Seventy-eight ingredients, including everyday alcohol and kava, deepen drowsiness, and the worst of them can dangerously slow breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Zuclopenthizol interaction page

One more smart check

Taking Yerba Mansa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 139 real supplement products containing Yerba Mansa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yerba Mansa. Your product may carry other ingredients that interact with Zuclopenthizol too, on top of Yerba Mansa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yerba Mansa and Zuclopenthizol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yerba Mansa
Top half

#432 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zuclopenthizol
Top half

#1,097 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Yerba Mansa

What is Yerba Mansa?

Yerba Mansa
  • Sore throat and respiratory congestion
  • Skin irritation and wounds
  • Mouth and gum inflammation
  • Urinary and digestive complaints
  • Antimicrobial support

Yerba mansa is a traditional Southwestern and Mexican medicinal plant used for sore throats, skin problems, and infections. Modern scientific evidence in humans is very limited, so its effectiveness is largely unproven. If you want to try it, talk to a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Read the full Yerba Mansa monograph & all interactions
Keep checking

Other Drugs & Yerba Mansa

Browse every other medication we’ve checked against Yerba Mansa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Yerba Mansa page.

No interaction 2,582 drugs checked — show the list

We also checked Yerba Mansa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Yerba Mansa list.

See the full Yerba Mansa interactions page
See every supplement checked against Zuclopenthizol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Yerba Mansa monograph › Uses, safety, and every drug interaction in one place Zuclopenthizol supplement interactions › Every supplement checked against Zuclopenthizol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Yerba Mansa and Zuclopenthizol Together: Common Questions

Can you take Yerba Mansa with Zuclopenthizol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Yerba Mansa and Zuclopenthizol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Zuclopenthizol and Yerba Mansa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.