Drug & supplement interaction

Yogurt + Fluconazole

Fluconazole brand names: Diflucan, Diflucan Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Yogurt and Fluconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Yogurt and Fluconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluconazole and Yogurt in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yogurt safety at a glance

Yogurt overall Generally safe Yogurt is generally safe as a food for most healthy people.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of the intravaginal use of yogurt during bre... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluconazole and Yogurt? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fluconazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fluconazole is filed under 7 classifications — including antifungals, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Yogurt has documented interactions with 3 drug classes — the most serious being ciprofloxacin (cipro) (moderate), tetracycline antibiotics (moderate) and nilotinib (tasigna) (minor) — and none of Fluconazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Yogurt Does Interact With Other Medications

Yogurt has 21 moderate, 1 minor known drug interactions in our database — Fluconazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 21 Minor 1 No known interaction 2,808 (incl. Fluconazole)
Taking anything else?

Check Another of Your Medications Against Yogurt

Covers the 2,830 medications we’ve checked against Yogurt. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Yogurt and Fluconazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Nausea Additional detail

    Yogurt

    “Orally, consuming yogurt with or without added probiotics has been reported to cause diarrhea, stomach pain, nausea, and vomiting in clinical research.”

    Yogurt · Natural Medicines adverse-effect record, reported in diarrhea.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Yogurt

    “Orally, patients with milk allergy may be allergic to the protein in yogurt. Symptoms include urticaria, wheezing, cough, and rarely vomiting and diarrhea.

    Fatal Lacticaseibacillus rhamnosus septicemia has been reported in an immunocompromised patient consuming yogurt and taking prolonged courses of multiple broad-spectrum antibiotics.”

    Yogurt · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 101751. Küçükosmanoglu E, Özen E, Eltan SB, Özkars MY, Keskin Ö. Most children who are allergic to cow's milk tolerate yogurt. J Int Med Res. 2018;46(12):5099-5106. PubMed
    2. 8561. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

  • A skin rash Additional detail

    Yogurt

    “Orally, consuming yogurt containing Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus, and Bifidobacterium lactis BB-12, 4 ounces daily, has been associated with one report of dermatitis in one clinical trial.”

    Yogurt · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 93707. Merenstein DJ, Smith KH, Scriven M, Roberts RF, Sanders ME, Petterson S. The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial. Eur J Clin Nutr. 20 PubMed

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

Reported for Yogurt but not commonly for Fluconazole: hives, wheezing and cough.

Effects for Fluconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Yogurt come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Yogurt in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When consumed in amounts commonly found in foods.

Pregnancy Possibly Safe

When used intravaginally. A small clinical study in pregnancy reported no adverse reactions.

Lactation Likely Safe

When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of the intravaginal use of yogurt during breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Fluconazole Is Prescribed For, and What Yogurt Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Fluconazole is a prescription medicine with approved uses on its FDA label. Yogurt is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Fluconazole is prescribed for: Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Read the rest of what Fluconazole is prescribed for

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Yogurt has been studied for:

  • Vaginal candidiasis studied, not established Yogurt has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Yogurt for vaginal candidiasis

    Intravaginal yogurt has only been evaluated in combination with other ingredients; its benefits when used alone are unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Fluconazole on your own; if you are taking Yogurt for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Yogurt or Fluconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Yogurt or Fluconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fluconazole

This page covers Yogurt only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluconazole page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 54 moderate · 23 minor.

From our pharmacist’s overview on the Fluconazole page

“Fluconazole (Diflucan) treats fungal infections, and I would pair it with supplements carefully. Nearly half of the 81 ingredients with an interaction on file, 38 of them, put extra strain on the liver, which is already busy processing the antifungal.”

Reviewed by 2 · Jul 18, 2026

Open the Fluconazole interaction page

One more smart check

Taking Yogurt as Part of a Dietary Supplement Product? Check It for Interactions

We hold 45 real supplement products containing Yogurt, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yogurt. Even though Yogurt itself has no known interaction with Fluconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yogurt and Fluconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yogurt
Steady interest

#901 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluconazole
Top 25%

#429 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yogurt reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yogurt and Fluconazole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yogurt

What is Yogurt?

  • Digestive health
  • Restoring gut bacteria after antibiotics
  • Vaginal yeast or bacterial balance
  • Source of protein and calcium
  • General immune and gut support

Yogurt is a fermented dairy food that often contains live bacteria (probiotics) and provides protein, calcium, and other nutrients. For most healthy people it is a safe, nutritious food, and some yogurts with live cultures may help with digestion and gut balance, though evidence varies by strain and condition. If you are lactose intolerant, have a milk allergy, or have a weakened immune system, talk to your pharmacist or doctor first.

Fermented milk product (made with live bacterial cultures) · Plain yogurt, Greek yogurt, drinkable yogurt (kefir-style), probiotic yogurt, dairy-free yogurt alternatives

An interaction check asks whether these two react with each other — it does not ask whether Yogurt is a good idea for someone in your situation. Here is what our Yogurt record says about it on its own.

Yogurt: dosing

There is no official "dose" for yogurt because it is a food, not a standardized medicine. The amount and type of live bacteria can vary widely from product to product, and many people simply eat one or more servings a day as part of a healthy diet.If you are using yogurt specifically for its probiotic content, look for a label that says "live and active cultures" and check whether the strains are listed. There is no proven "best" amount for any health condition. If you want a specific probiotic strain or dose, a standardized probiotic supplement may be more reliable.

From our Yogurt monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yogurt monograph & all interactions
Medication

About Fluconazole

What Is Fluconazole Used For?

Brand names: Diflucan, Diflucan Injection

Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Most-Reported Side Effects for Fluconazole

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,205 reports
Nausea 3,813 reports
Diarrhea 3,614 reports
Fatigue 3,266 reports
Headache 2,930 reports
See full Fluconazole drug information
Keep checking

Other Drugs & Yogurt

Browse every other medication we’ve checked against Yogurt — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
21Moderate
1Minor
2,807No known interaction
21 Moderate 1 Minor 2,807 No interaction
Moderate

21 interactions

Minor

1 interaction

No interaction 2,807 drugs checked — show the list

We also checked Yogurt against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,807 medications checked with no known interaction — see the full Yogurt list.

See the full Yogurt interactions page
See every supplement checked against Fluconazole, ranked by severity
Evidence & sources

Yogurt References

The 9 references that drive our Yogurt monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Neri A, Sabah G, Samra Z. Bacterial vaginosis in pregnancy treated with yogurt. Acta Obstet Gynecol Scand 1993;72:17-9.
  3. Neuvonen PJ, Kivisto KT, Lehto P. Interference of dairy products with the absorption of ciprofloxacin. Clin Pharmacol Ther 1991;50:498-502. PubMed
  4. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  5. Liu J, Tang W, Sang L, Dai X, Wei D, Luo Y, Zhang J. Milk, yogurt, and lactose intake and ovarian cancer risk: a meta-analysis. Nutr Cancer. 2015;67(1):68-72. PubMed
  6. Merenstein DJ, Smith KH, Scriven M, Roberts RF, Sanders ME, Petterson S. The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial. Eur J Clin Nutr. 20 PubMed
  7. Yin OQ, Rudoltz M, Galetic I, Filian J, Krishna A, Zhou W, Custodio J, Golor G, Schran H. Effects of yogurt and applesauce on the oral bioavailability of nilotinib in healthy volunteers. J Clin Pharmacol. 2011 Nov;51(11):1580-6. PubMed
  8. Küçükosmanoglu E, Özen E, Eltan SB, Özkars MY, Keskin Ö. Most children who are allergic to cow's milk tolerate yogurt. J Int Med Res. 2018;46(12):5099-5106. PubMed
  9. Zhang K, Dai H, Liang W, Zhang L, Deng Z. Fermented dairy foods intake and risk of cancer. Int J Cancer. 2019;144(9):2099-2108. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Yogurt and Fluconazole Together: Common Questions

Is it safe to take Yogurt with Fluconazole?
We do not list a known interaction between Yogurt and Fluconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Yogurt and Fluconazole have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Yogurt and Fluconazole used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Yogurt in each. That is a conversation for your prescriber, especially if Fluconazole is being adjusted to a target.
How was the Yogurt and Fluconazole combination checked?
Interactions in our licensed database are recorded against drug classes. Fluconazole is filed under 7 classifications, and Yogurt has documented interactions with 3 drug classes — none of Fluconazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Yogurt interact with any other medications?
Yes. Yogurt has 22 documented drug interactions in our database — Fluconazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fluconazole interact with any supplements?
Yes. Fluconazole has documented interactions with 81 supplements in our database — Yogurt is not one of them. The Fluconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Yogurt monograph Uses, safety profile, and every drug interaction in one place Fluconazole drug information The full plain-English guide to this medication Fluconazole supplement interactions Every supplement checked against Fluconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fluconazole and Yogurt?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.