Medication interaction hub

What Supplements Interact with Chlorpheniramine Tannate, Phenylephrine Tannate?

Chlorpheniramine Tannate, Phenylephrine Tannate brand name: Ricobid. Every interaction below applies to the brands too.

229 Interactions 10 Major 175 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine Tannate, Phenylephrine Tannate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine Tannate, Phenylephrine Tannate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ricobid pairs chlorpheniramine, an antihistamine, with phenylephrine, a decongestant, and 229 supplement and herbal ingredients interact with it, ten of them at major severity. That count earns real caution, not a shrug. Most of the risk runs in two directions: stimulant herbs like ephedra stack with phenylephrine and push blood pressure higher, while anticholinergic botanicals pile onto chlorpheniramine's drying, sedating side effects. Grapefruit is major-rated too, shown in human studies to raise levels of drugs broken down the way this one is.

Someone taking Ricobid through a rough week of congestion is often also drinking coffee or tea, and caffeine sits among the 175 moderate entries for that same stimulant-stacking reason, alongside herbs adding serotonin effects or sun sensitivity. Another 44 rate minor. A useful rule here is that if a product revs you up or dries you out on its own, expect this combination to hit harder.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 175 Minor 44 No known interaction 1,223

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorpheniramine Tannate, Phenylephrine Tannate: Top Interactions at a Glance

The Chlorpheniramine Tannate, Phenylephrine Tannate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorpheniramine Tannate, Phenylephrine Tannate Combinations Today

The Chlorpheniramine Tannate, Phenylephrine Tannate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Goldthread + Chlorpheniramine Tannate, Phenylephrine Tannatei

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Chlorpheniramine Tannate, Phenylephrine Tannatei

Bitter orange might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Goldenseal + Chlorpheniramine Tannate, Phenylephrine Tannatei

Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Valerian + Chlorpheniramine Tannate, Phenylephrine Tannatei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Hops + Chlorpheniramine Tannate, Phenylephrine Tannatei

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Read the full interaction Moderate Likelihood Possible Acetyl-l-carnitine + Chlorpheniramine Tannate, Phenylephrine Tannatei

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, wh...

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine Tannate, Phenylephrine Tannate

All 1,452 ingredients in our database, ranked by severity — 229 with a Chlorpheniramine Tannate, Phenylephrine Tannate interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine Tannate, Phenylephrine Tannate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldthread with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Bitter Orange with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Goldenseal with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Valerian with Chlorpheniramine Tannate, Phenylephrine Tannate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Hops with Chlorpheniramine Tannate, Phenylephrine Tannate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Purple Nut Sedge with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Quercetin with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Rabdosia Rubescens with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Raspberry Ketone with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Rauwolscine with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Resveratrol with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Rooibos with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Rue with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Sage with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Same with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.

Full Same + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Schizonepeta with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Securinega Suffruticosa with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Slippery Elm with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Sulforaphane with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Chlorpheniramine Tannate, Phenylephrine Tannate answer

Can you take Sweet Annie with Chlorpheniramine Tannate, Phenylephrine Tannate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Chlorpheniramine Tannate, Phenylephrine Tannate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine Tannate, Phenylephrine Tannate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine Tannate, Phenylephrine Tannate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine Tannate, Phenylephrine Tannate sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine Tannate, Phenylephrine Tannate through this category.

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Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine Tannate, Phenylephrine Tannate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine Tannate, Phenylephrine Tannate.

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Pharmacist Counseling Corner

Chlorpheniramine Tannate, Phenylephrine Tannate & Supplements: Common Questions

What supplements interact with Chlorpheniramine Tannate, Phenylephrine Tannate?
Our database currently documents 229 ingredients with a known Chlorpheniramine Tannate, Phenylephrine Tannate interaction (10 major, 175 moderate, 44 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 229. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Chlorpheniramine Tannate, Phenylephrine Tannate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Ephedra, Henbane and Lithium, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine Tannate, Phenylephrine Tannate?
Plenty of supplements coexist fine with Chlorpheniramine Tannate, Phenylephrine Tannate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Ricobid have the same supplement interactions as Chlorpheniramine Tannate, Phenylephrine Tannate?
Yes — Ricobid all contain Chlorpheniramine Tannate, Phenylephrine Tannate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine Tannate, Phenylephrine Tannate and my other medications?
This page covers Chlorpheniramine Tannate, Phenylephrine Tannate against supplements and herbal ingredients. Checking Chlorpheniramine Tannate, Phenylephrine Tannate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.