Medication interaction hub

What Supplements Interact with Loxapine?

Loxapine brand names: Loxitane, Adasuve. Every interaction below applies to the brands too.

123 Interactions 11 Major 95 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Loxapine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Loxapine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Loxapine (Loxitane, Adasuve) treats schizophrenia, and it causes drowsiness on its own, which is why 78 of the 123 supplement and herbal ingredients on this page deepen that sedation, at the extreme to the point of slowed breathing. Alcohol is the clearest example, with beer and wine both rated major on solid human evidence, and kava sits in the same tier. Eleven entries here rate major, so study this page before you pair loxapine with any supplement on it.

Two other patterns cover most of the rest. Thirty ingredients stack anticholinergic side effects (dry mouth, constipation, confusion) on top of loxapine's own, and 17 can change how much of an oral dose your body absorbs, activated charcoal chief among them, so take those well apart from your pills. Ninety-five entries rate moderate and 17 minor, but the sedating group is where I want your attention first.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 95 Minor 17 No known interaction 1,329

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Loxapine: Top Interactions at a Glance

The Loxapine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 123 interacting ingredients — plus 1,329 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Loxapine Combinations Today

The Loxapine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Catnip + Loxapinei

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction Moderate Likelihood Possible Marjoram + Loxapinei

In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Read the full interaction Moderate Likelihood Possible Teazle + Loxapinei

In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Read the full interaction Moderate Likelihood Possible Methylene Blue + Loxapinei

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full interaction Moderate Likelihood Possible Motherwort + Loxapinei

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Read the full interaction Major Likelihood Likely Beer + Loxapinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Loxapine

All 1,452 ingredients in our database, ranked by severity — 123 with a Loxapine interaction on file and 1,329 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Loxapine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Catnip with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Loxapine answer

Can you take Marjoram with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Loxapine answer

Can you take Teazle with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Full Teazle + Loxapine answer

Can you take Methylene Blue with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Methylene Blue + Loxapine answer

Can you take Motherwort with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Loxapine answer

Can you take Magnolia with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.

Full Magnolia + Loxapine answer

Can you take Manganese with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.

Full Manganese + Loxapine answer

Can you take Marsh Labrador Tea with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Loxapine answer

Can you take Melatonin with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Loxapine answer

Can you take Nutmeg with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Loxapine answer

Can you take Oregon Grape with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Loxapine answer

Can you take Passion Flower with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Loxapine answer

Can you take Phellodendron with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Loxapine answer

Can you take Phenibut with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Loxapine answer

Can you take Phosphatidylserine with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Loxapine answer

Can you take Pinellia Ternata with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Loxapine answer

Can you take Poria Mushroom with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Loxapine answer

Can you take Purple Nut Sedge with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Loxapine answer

Can you take Saffron with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Loxapine answer

Can you take Sage with Loxapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Loxapine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Loxapine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Loxapine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Loxapine sits in 4 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Loxapine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Loxapine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Loxapine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Loxapine through this category.

About Loxapine

Loxapine is an antipsychotic medication used to treat schizophrenia (as oral capsules) and acute agitation associated with schizophrenia or bipolar I disorder (as an inhaled powder, Adasuve).

Generic name: Loxapine  ·  Brand names: Loxitane, Adasuve.

See the full Loxapine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Loxapine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Loxapine.

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Pharmacist Counseling Corner

Loxapine & Supplements: Common Questions

What supplements interact with Loxapine?
More than you might expect — 123 in total, though they are far from equal: 11 are rated major, 95 moderate, and 17 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Loxapine supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Loxapine?
Usually yes — most people on Loxapine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Loxitane have the same supplement interactions as Loxapine?
Yes — Loxitane, Adasuve all contain Loxapine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Loxapine and my other medications?
This page covers Loxapine against supplements and herbal ingredients. Checking Loxapine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Loxapine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.