Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

BCAA 6000 Ingredients & Drug Interactions

by Gaspari Nutrition

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

BCAA 6000 is a dietary supplement by Gaspari Nutrition with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BCAA 6000 by Gaspari Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BCAA 6000 contains 4 active ingredients: three branched-chain amino acids (L-leucine, L-isoleucine, and L-valine) — these are amino acids your muscles use for energy and repair — plus vitamin B6. The product also contains several inactive ingredients like microcrystalline cellulose and magnesium stearate that help hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle recovery and sports performance.
  • We looked for evidence on: Muscle soreness, Exercise recovery, Muscle protein synthesis, Athletic performance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Our data covers vitamin B6 only. Vitamin B6 is effective for treating sideroblastic anemia (a type of low red blood cell count) and vitamin B6 deficiency itself.

It's also effective for a rare genetic seizure disorder called pyridoxine-dependent epilepsy, likely effective for high homocysteine levels (a heart risk factor), and possibly effective for pregnancy-related nausea and vomiting. We don't hold effectiveness information for the three branched-chain amino acids in this product.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily. Most side effects are mild — headache, nausea, heartburn, loss of appetite — but high doses taken over time can damage nerves (sensory neuropathy), especially above 1,000 mg daily or with cumulative doses of 1,000 grams or more.

For pregnancy, vitamin B6 is rated likely safe, though there's also a possibly unsafe rating on file — talk with your doctor or pharmacist if you're pregnant or planning to be. Normal dietary amounts and standard supplement doses are considered fine, but avoid high doses unless a clinician advises otherwise.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 210 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take BCAA 6000, double-check if you're on blood pressure medications (antihypertensives), amiodarone for heart rhythm, phenobarbital or phenytoin for seizures, or levodopa for Parkinson's symptoms (especially if you're not taking it with carbidopa). These are the medication types our data flags as potentially affected by the vitamin B6 in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medication, a heart rhythm drug, or certain seizure or Parkinson's medications, check with your pharmacist before starting this product. The amino acids here don't have documented interactions we can verify, but the vitamin B6 does.

Talk with your pharmacist — especially if you're pregnant, on multiple medications, or taking high-dose supplements.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BCAA 6000, straight from the product label.

Brand Gaspari Nutrition
Barcode (UPC) 646511027336
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228168
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BCAA 6000 by Gaspari Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Tablet(s)
Maximum serving Sizes:
6 Tablet(s)
Servings per container
30
UPC/BARCODE
646511027336
IngredientAmount% DV
L-Leucine4000 mg--
L-Isoleucine1000 mg--
L-Valine1000 mg--
Vitamin B63 mg150%

Other ingredients: Dicalcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Sodium Carboxymethylcellulose, Dextrin, Dextrose, Soy Lecithin, Sodium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Benefits

Formula

4 g Leucine/ 1 g Isoleucine/ 1 g Valine

Branched chain amino acid tablets

The ultimate branch chain amino acid tablets BCAA 6000 from Gaspari Nutrition uses a "leucine heavy", 4:1:1 ratio of 100% pure branched chain amino acids in a formula that provides clinically validated and effective quantities of these critical nutrients in every dose. The addition of advanced, highly bio-available form of vitamin B-6 to the BCAA 6000 complex will also help to enhance your energy levels and endurance helping to further maximize your training while simultaneously enhancing recovery.

Formulation

Helps to decrease muscle soreness after exercise Helps to optomise aerobic & anaerobic sports performance When combined with proper exercise and nutrition program.

Helps enhance post exercise muscle recovery Helps to promote protein synthesis in lean muscle

Made in the USA from domestic and international ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

With meals Pre During Post Between meals

Suggested use: As a dietary supplement consume one serving (6 tablets) with 8-16 ounces (250-500 mL) of water or your favorite beverage before training, after training, or between meals.

Precautions

Allergens: Contains soy.

Keep out of reach of children. Check with a qualified healthcare professional before using this product if you are under 18 years of age, pregnant or nursing a baby or if you have any known or suspected medical condition(s) and/or are taking any prescription or OTC medication(s).

Check with a qualified healthcare professional before using this product if you are under 18 years of age, pregnant or nursing a baby or if you have any known or suspected medical condition(s) and/or are taking any prescription or OTC medication(s).

Tamper evident: Do not use if seal under cap is broken or missing. Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov

Brand IP Statement(s)

2019 Gaspari Nutra, LLC. Gaspari Nutrition and BCAA 6000 are trademarks of Gaspari Nutra, LLC. - All rights reserved.

Storage

Store in a cool, dry place.

See for yourself

BCAA 6000 by Gaspari Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BCAA 6000 by Gaspari Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Leucine

4000 mg per serving

L-Isoleucine

1000 mg per serving

L-Valine

1000 mg per serving

Vitamin B6

Interacts with
210 drugs
3 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Sodium Carboxymethylcellulose, Dextrin, Dextrose, Soy Lecithin, Sodium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

BCAA 6000 by Gaspari Nutrition Drug Interactions

Want to check YOUR meds against BCAA 6000?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
210Drugs
205 Moderate 5 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in BCAA 6000 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for BCAA 6000, from the product label.

Gaspari Nutrition

See all Gaspari Nutrition products
Name
Gaspari Nutrition
Phone Number
1.732.364.3777
Web Address
gasparinutrition.com
Pharmacist Counseling Corner

BCAA 6000 by Gaspari Nutrition: Common Questions

Does BCAA 6000 by Gaspari Nutrition interact with any medications?
Yes. Based on its ingredients, BCAA 6000 has a known interaction with 210 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BCAA 6000 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin B6 safe at the dose in this product?
Vitamin B6 is well tolerated at doses under 100 mg daily. We don't have the exact amount in BCAA 6000, so check the label and talk with your pharmacist if you're taking additional B6 from other sources — cumulative high doses over time can harm your nerves.
Can I take this if I'm pregnant?
Vitamin B6 is rated likely safe in pregnancy at normal amounts, though we also have a possibly unsafe rating on file. There's not enough clarity in the data to say yes or no — talk with your doctor or pharmacist for personalized advice, especially since you'll be getting B6 from this product.
What are branched-chain amino acids for?
BCAAs are amino acids your muscles use for energy during and after exercise, and they support muscle repair. People often take them as a workout supplement, though we don't have effectiveness data for them in our system.
What are the most common side effects of vitamin B6?
At normal doses, abdominal pain, headache, heartburn, nausea, and loss of appetite are the most common side effects. High doses over time can cause nerve damage (sensory neuropathy), which is rare but serious.
Will this interact with my seizure medication?
If you take phenobarbital (Luminal) or phenytoin (Dilantin), high doses of vitamin B6 can reduce how well they work by speeding up how your body clears them. Check the dose in this product and talk with your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BCAA 6000 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BCAA 6000 label
Sources

Sources & How We Checked

BCAA 6000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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