Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

BoswelliaZyme Complex Ingredients & Drug Interactions

by Energetix

BoswelliaZyme Complex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BoswelliaZyme Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BoswelliaZyme Complex is a dietary supplement by Energetix with 3 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indian Frankincense. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BoswelliaZyme Complex by Energetix

Ask about any prescription or over-the-counter medication and we check it for interactions with BoswelliaZyme Complex by Energetix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BoswelliaZyme Complex by Energetix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BoswelliaZyme Complex contains 3 active ingredients. Indian Frankincense (Boswellia serrata) is a plant resin traditionally used to support joint and respiratory health.

Pancreatin is an enzyme blend from animal pancreas that aids digestion. Serrazimes-I appears to be an enzyme ingredient, though we don't hold detailed data on it.

The remaining ingredients—hydroxypropyl methylcellulose, purified water, and rice starch—are inactive ingredients that form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Proteolytic enzyme formulation with boswellic acids.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Asthma, Crohn disease, Ulcerative colitis, Irritable bowel syndrome (IBS) — and 3 related terms.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Asthma, Crohn disease, Exercise-induced muscle soreness, Ulcerative colitis, and more.

Indian Frankincense has possibly effective evidence for osteoarthritis, meaning some clinical studies support its use for joint discomfort. For allergic rhinitis (hay fever), asthma, Alzheimer disease, and cluster headache, the evidence is insufficient to rate—we simply don't have reliable data yet on whether it works for those conditions.

Effectiveness data is not on file for Pancreatin and Serrazimes-I in this product.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata is generally well tolerated when taken by mouth short-term, though quality and dose vary widely between products, so consistency matters. The most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea; headache appeared in roughly 11% of participants in one clinical trial.

Dizziness and vertigo have also been reported. Rarely, large amounts of boswellia gum resin can form a bezoar (a hard mass in the stomach), though this is uncommon.

Do not take this product during pregnancy—there is not enough safety data. Avoid it while breastfeeding as well, since safety is unknown.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking BoswelliaZyme Complex, check any medications you take that are processed by liver enzymes CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4—these Moderate-severity interactions could raise drug levels in your blood. Also check if you take immunosuppressants (drugs that quiet your immune system).

Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

BoswelliaZyme Complex may be worth considering if you have osteoarthritis and want to try a plant-based approach, but the liver enzyme interactions are significant. If you take any prescription medications, especially ones for depression, blood pressure, heart rhythm, or seizures, you need to check them with your pharmacist before starting.

Pregnant and breastfeeding women should skip this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BoswelliaZyme Complex, straight from the product label.

Brand Energetix
Barcode (UPC) 364578131628
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 333018
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BoswelliaZyme Complex by Energetix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
364578131628
IngredientAmount% DV
Pancreatin192 mg--
Indian Frankincense424 mg--
Serrazimes-I9.64 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Purified, Rice Starch

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

As a dietary supplement, take 2 capsules three times daily or as directed by a healthcare professional.

Precautions

Do not use if neck wrap is broken or missing.

If pregnant or breast-feeding, ask a healthcare professional before use.

Keep out of reach of children.

Storage

Store at room temperature out of direct sunlight.

Brand IP Statement(s)

Serrazimes is a trademark of Deerland Probiotics & Enzymes, Inc.

FDA Statement of Identity

Dietary Supplement

Formula

Proteolytic Enzyme Formulation with Boswellic Acids

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BoswelliaZyme Complex by Energetix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BoswelliaZyme Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BoswelliaZyme Complex by Energetix

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pancreatin

192 mg per serving

Indian Frankincense

Interacts with
952 drugs
424 mg per serving Form: Boswellia serrata

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Indian Frankincense monograph & interactions

Serrazimes-I

9.64 mg per serving Form: Endoprotease, Exoprotease

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Purified, Rice Starch. These complete the product’s ingredient list but are not active constituents.

Interaction report

BoswelliaZyme Complex by Energetix Drug Interactions

Want to check YOUR meds against BoswelliaZyme Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Indian Frankincense 952

Individual Drug Interactions

The ingredients in BoswelliaZyme Complex interact with 952 drugs. Click any drug to see the details.

1 of the 3 ingredients in BoswelliaZyme Complex interact with drugs. Each result below shows which ingredient is responsible. Indian Frankincense

Each ingredient & the kinds of drugs it affects

For each ingredient in BoswelliaZyme Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Indian Frankincense6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Indian Frankincense full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BoswelliaZyme Complex, from the product label.

Energetix

See all Energetix products
Name
Energetix Corp.
City
Dahlonega
State
GA
ZipCode
30533
Phone Number
800.990.7085
Web Address
www.energetix.com
Pharmacist Counseling Corner

BoswelliaZyme Complex by Energetix: Common Questions

Does BoswelliaZyme Complex by Energetix interact with any medications?
Yes. Based on its ingredients, BoswelliaZyme Complex has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BoswelliaZyme Complex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take BoswelliaZyme Complex while pregnant?
No, you should avoid it. There is not enough safety data on Boswellia serrata during pregnancy, so it's best not to use it if you're pregnant or planning to become pregnant. Talk with your doctor or midwife about alternatives.
Is it safe to breastfeed while taking this product?
Safety is unknown while breastfeeding, so you should avoid it. If you're nursing and interested in joint or digestive support, ask your doctor or pharmacist for options they've cleared for breastfeeding.
What side effects might I notice from the Boswellia?
The most common are stomach upset—abdominal pain, diarrhea, nausea, heartburn—plus headache, dizziness, and itching. Headache was reported in about 1 in 10 people in one clinical study. If you develop severe or ongoing symptoms, stop and talk to your pharmacist.
Does this product actually work for osteoarthritis?
Boswellia serrata has possibly effective evidence for osteoarthritis, which means some clinical studies support it may help with joint discomfort. Results vary by person and product quality, so it may take a few weeks to notice a difference.
Why does this product interact with so many medications?
The Indian Frankincense ingredient can slow down five major liver enzyme systems your body uses to break down drugs. When those enzymes slow down, medications can build up to higher levels in your blood, potentially making them too strong. That's why checking your specific medications is essential.
What is Pancreatin, and what does it do?
Pancreatin is an enzyme blend from animal pancreas that helps break down food—fat, protein, and starch—in your digestive tract. It's added to this product to support digestion alongside the anti-inflammatory Boswellia ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BoswelliaZyme Complex label
Go deeper

The Full Monographs Behind BoswelliaZyme Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

BoswelliaZyme Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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