Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Brocco-Glutathione Ingredients & Drug Interactions

by Nature's Answer

Brocco-Glutathione label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brocco-Glutathione against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brocco-Glutathione is a dietary supplement by Nature's Answer with 4 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are HiActives organic Broccoli. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brocco-Glutathione by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Brocco-Glutathione by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Brocco-Glutathione by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Brocco-Glutathione contains 4 ingredients total: two are active and two are inactive. The active ingredients are HiActives organic Broccoli (listed twice in the formulation) and Setria Glutathione.

Broccoli is a cruciferous vegetable concentrate that contains glucosinolates — compounds your body may use to support certain cellular processes. Glutathione is a naturally occurring antioxidant found in cells.

The inactive ingredients are vegetable cellulose (the capsule), rice flour, and calcium silicate (used for flow and consistency).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Cisplatin-induced neurotoxicity — rated "Possibly Effective" (Glutathione) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).

For broccoli, the evidence shows it's possibly effective for colorectal cancer prevention. For bladder, breast, gastric cancers and fibromyalgia, the evidence isn't established enough in the data we hold to rate it.

For glutathione, the evidence shows it's possibly effective for reducing nerve damage (neurotoxicity) from the chemotherapy drug cisplatin. For fatty liver disease, Alzheimer's disease, athletic performance, and cataracts, there isn't enough reliable evidence in our data to make a rating.

The evidence, ingredient by ingredient Broccoli Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is generally well tolerated in normal amounts, but concentrated supplements are less studied — the data advises caution. Some people have experienced loose stools, diarrhea, abdominal pain, and cramping with broccoli seed and sprout extracts, especially at high doses.

Broccoli is rated likely safe in pregnancy and lactation. Glutathione in oral form appears generally well tolerated in the short term, but long-term safety isn't clear.

The data advises against glutathione during pregnancy and breastfeeding unless your doctor advises otherwise — there isn't enough reliable safety information. One note: inhaled glutathione can cause airway narrowing and shortness of breath in people with asthma, though this product is a capsule taken by mouth.

Side effects, ingredient by ingredient Broccoli Glutathione

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take medications processed through CYP1A2 substrates (such as certain blood pressure drugs, some antidepressants, and other medications) or CYP2A6 substrates (including some cancer drugs and blood thinners), check with your doctor or pharmacist before starting this product — broccoli may reduce their effectiveness. The severity of this interaction is Moderate.

No interactions are documented for the glutathione ingredient we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with colorectal cancer support and nerve protection from certain chemotherapy, though evidence is still developing for other uses. The main caution is that broccoli can speed up how your liver metabolizes certain medications, which could make them less effective.

Before you start, check your current prescriptions with your doctor or pharmacist — especially if you take drugs processed through CYP1A2 or CYP2A6 pathways. If you're pregnant or breastfeeding, talk with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brocco-Glutathione, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000160301
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 184755
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brocco-Glutathione by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
UPC/BARCODE
083000160301
IngredientAmount% DV
HiActives organic Broccoli250 mg--
Setria Glutathione1000 mg--
HiActives organic Broccoli1000 mg--
Setria Glutathione250 mg--

Other ingredients: Vegetable Cellulose, Rice Flour, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Discover Brocco-Glutathione and trust the Difference... The True Nature of Our Standards goes way beyond the norm...

Setria is a registered trademark of Kyowa Hakko Bio Co., Ltd.

HiActives is a registered trademark of VDF FutureCeuticals, Inc., used under license.

Advanced Botanical Fingerprint Technology

Discover Brocco-Glutathione

2017 Nature's Answer

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Seals/Symbols

Gluten Free

General Statements

Since 1972

Antioxidant Benefits and Support

500 mg per capsule

Formula

And HiActives Broccoli Sprouts

Brocco-Glutathione with Setria Glutathione

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten-free

Vegetarian/Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take up to four (4) capsules throughout the day.

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If you are pregnant, nursing, taking any medications, planning any medical procedure or have a medical condition, consult with your healthcare practitioner before use.

General

18030 Rev. 217

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brocco-Glutathione by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brocco-Glutathione label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brocco-Glutathione by Nature's Answer

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

HiActives organic Broccoli

Interacts with
187 drugs
250 mg per serving Form: Total Glucosinolates

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

HiActives organic Broccoli monograph & interactions

Setria Glutathione

No known
interactions
1000 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria Glutathione monograph & interactions

HiActives organic Broccoli

Interacts with
187 drugs
1000 mg per serving Form: Total Glucosinolates

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

HiActives organic Broccoli monograph & interactions

Setria Glutathione

No known
interactions
250 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria Glutathione monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Rice Flour, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brocco-Glutathione by Nature's Answer Drug Interactions

Want to check YOUR meds against Brocco-Glutathione?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

HiActives organic Broccoli 187

Individual Drug Interactions

The ingredients in Brocco-Glutathione interact with 187 drugs. Click any drug to see the details.

1 of the 4 ingredients in Brocco-Glutathione interact with drugs. Each result below shows which ingredient is responsible. HiActives organic Broccoli

Each ingredient & the kinds of drugs it affects

For each ingredient in Brocco-Glutathione with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

HiActives organic Broccoli2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
HiActives organic Broccoli full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brocco-Glutathione, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Brocco-Glutathione by Nature's Answer: Common Questions

Does Brocco-Glutathione by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Brocco-Glutathione has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brocco-Glutathione contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant?
Broccoli is rated likely safe in pregnancy, but glutathione doesn't have enough reliable safety information — the data advises against it during pregnancy unless your doctor says otherwise. Talk with your doctor or pharmacist about whether this product is right for you.
Can I take this while breastfeeding?
Broccoli is rated likely safe, but glutathione safety during breastfeeding isn't well established — the data recommends caution and avoidance. Check with your doctor or pharmacist before starting.
What side effects might I notice?
Loose stools, diarrhea, abdominal pain, and cramping have been reported with broccoli seed and sprout extracts, especially at higher doses. Glutathione is generally well tolerated when taken by mouth in the short term.
Does broccoli really speed up how my body breaks down medications?
Research shows that eating 500 grams of fresh broccoli daily for several days can increase liver enzyme activity by a significant amount. While this supplement is concentrated and not the full food amount, it may still affect certain medications — that's why checking with your doctor or pharmacist is important if you take drugs metabolized by CYP1A2 or CYP2A6.
What is glutathione supposed to do?
Glutathione is an antioxidant found naturally in your cells. The evidence shows it's possibly effective for reducing nerve damage from the chemotherapy drug cisplatin. For other uses like fatty liver disease or Alzheimer's disease, there isn't enough reliable evidence to know if it works.
Is broccoli in this supplement as safe as eating broccoli?
Broccoli as a food is safe for most people, but concentrated supplements like this one are less studied. The data recommends caution with concentrated extracts unless your doctor approves — stick with your doctor or pharmacist if you have questions about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brocco-Glutathione label
Go deeper

The Full Monographs Behind Brocco-Glutathione’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph →
Sources

Sources & How We Checked

Brocco-Glutathione's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Glutathione 1 reference
  1. Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed

See these in context on the Glutathione monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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