CapriPlus Ingredients & Drug Interactions
by Karuna
What is this page for?
First and foremost: checking CapriPlus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CapriPlus is a dietary supplement by Karuna with 4 active ingredients. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 1,015 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garlic, Powder, Caprylic Acid, Oil of Oregano. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CapriPlus by Karuna
Ask about any prescription or over-the-counter medication and we check it for interactions with CapriPlus by Karuna — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of CapriPlus by Karuna
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
CapriPlus contains 4 active ingredients. Oil of Oregano is included for its traditional culinary use; Caprylic Acid is a naturally occurring fatty acid; Garlic Powder provides the compound allicin; and Sorbic Acid is a preservative.
The product also contains inactive ingredients—Vegetable Stearine, Stearate, Silicon Dioxide, Croscarmellose Sodium, and Ditab—which serve as binders, flow agents, and capsule materials.
Does it work?
Moderate evidence
The evidence in our data for what CapriPlus might do is limited. Garlic Powder shows possibly effective ratings for periodontitis (gum disease), fatty liver disease, diabetes, high blood pressure, and hardening of the arteries.
Oil of Oregano and Caprylic Acid are rated as having insufficient reliable evidence for the conditions listed in our data—including asthma, bronchitis, headache, upper respiratory infections, epilepsy, and essential tremor. The evidence simply isn't established well enough to make a claim either way.
How safe is it?
Well-documented data
Oil of Oregano is well tolerated at food amounts, though concentrated supplement doses are less studied. Most common side effect is mild stomach upset; rarely, allergic reactions including anaphylaxis have been reported in sensitive individuals.
Caprylic Acid appears generally well tolerated short-term, with mild abdominal discomfort and taste changes most common; rare reports include dizziness, headache, and fatigue. Garlic Powder is well tolerated overall, with common side effects being stomach pain, body odor, gas, bad breath, and nausea; allergic reactions can occur in sensitive people.
For pregnancy: Oregano oil should be avoided at medicinal or supplement doses—food amounts are likely fine. Garlic is likely safe at food amounts but possibly unsafe at supplement doses; talk with your doctor.
Caprylic Acid lacks safety data for pregnancy, so avoid supplement doses unless your doctor approves. During breastfeeding, oregano and garlic at food amounts are likely fine, but supplement-level doses aren't well studied.
Caprylic Acid occurs naturally in breast milk, but concentrated supplement safety is unknown, so use caution.
Meds to double-check
Moderate interaction found
Before taking CapriPlus, double-check with your pharmacist if you take blood thinners or antiplatelet drugs—garlic and oregano may raise bleeding risk. Blood pressure medications, diabetes drugs, NSAIDs (pain relievers), warfarin, protease inhibitors (HIV), tacrolimus (transplant), and certain drugs processed through specific liver pathways (CYP3A4 and CYP2E1 substrates) all carry Moderate-severity interactions with ingredients in this product.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
CapriPlus combines three ingredients with moderate interactions across a wide range of medications. If you take blood thinners, diabetes drugs, blood pressure medications, HIV protease inhibitors, tacrolimus, or certain pain relievers, talk with your pharmacist before adding this product.
The evidence for what it actually does isn't strong in our data.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CapriPlus, straight from the product label.
| Brand | Karuna |
|---|---|
| Barcode (UPC) | 018647091053 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 299261 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CapriPlus by Karuna, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sorbic Acid | 600 mg | -- |
| Oil of Oregano | 300 mg | -- |
| Caprylic Acid | 600 mg | -- |
| Garlic, Powder | 1200 mg | -- |
Other ingredients: Vegetable Stearine, Stearate, Silicon Dioxide, Croscarmellose Sodium, Ditab
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Caprylic acid, garlic and oil of oregano
Brand IP Statement(s)
Karuna Responsible Nutrition
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use for adults: Four tablets divided over one day, taken on an empty stomach, or as directed by your health care practitioner.
Formulation
This product contains no yeast, wheat, soy, corn, milk, sugar, artificial coloring, preservatives or flavoring.
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
Storage
Keep in a cool, dry place, tightly capped.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CapriPlus by Karuna label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CapriPlus by Karuna
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sorbic Acid
Oil of Oregano
Interacts with208 drugs
Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...
Oil of Oregano monograph & interactionsCaprylic Acid
Interacts with262 drugs
Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While...
Caprylic Acid monograph & interactionsGarlic, Powder
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Garlic, Powder monograph & interactionsOther (inactive) ingredients: Vegetable Stearine, Stearate, Silicon Dioxide, Croscarmellose Sodium, Ditab. These complete the product’s ingredient list but are not active constituents.
CapriPlus by Karuna Drug Interactions
HelloPharmacist Interaction Report
CapriPlus by Karuna contains three active ingredients with documented interactions: Oil of Oregano, Caprylic Acid, and Garlic Powder.
The most serious finding involves Garlic Powder, which carries Moderate-severity interactions across seven drug types. Most notably, garlic may increase bleeding risk with blood thinners and antiplatelet drugs (anticoagulants/antiplatelet medications), and it can affect how your liver and intestines process certain medications, potentially changing their levels in your bloodstream.
Read the full breakdown — every affected drug type, severity by severity
Oregano oil also interacts with blood thinners and antiplatelet drugs at Moderate severity, with a theoretical increased bleeding risk. It may also raise the risk of low blood sugar (hypoglycemia) when combined with diabetes medications.
Caprylic Acid carries Moderate interactions with blood pressure-lowering drugs (antihypertensive medications), pain relievers (NSAIDs), and warfarin specifically—all with a theoretical risk of raised drug levels.
Garlic carries additional Moderate interactions with diabetes drugs, blood pressure medications, drugs processed through specific liver pathways (CYP3A4 and CYP2E1 substrates), protease inhibitors for HIV, and tacrolimus for transplant patients. We could not check Sorbic Acid for interactions.
Altogether, these interactions span 1,016 individual medications. Before you start CapriPlus, use the medication checker on this page to run through your exact prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CapriPlus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CapriPlus interact with 1,015 drugs. Click any drug to see the details.
3 of the 4 ingredients in CapriPlus interact with drugs. Each result below shows which ingredient is responsible. Garlic, Powder Caprylic Acid Oil of Oregano
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with CapriPlus — through 2 ingredients. Tap an ingredient for the detail:
Oil Of OreganoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oil Of Oregano + Abciximab interactionGarlic, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic, Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with CapriPlus — through 2 ingredients. Tap an ingredient for the detail:
Garlic, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic, Powder + Abrocitinib interactionOil Of OreganoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oil Of Oregano + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with CapriPlus — through 2 ingredients. Tap an ingredient for the detail:
Oil Of OreganoAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Oil Of Oregano + Acarbose interactionGarlic, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Garlic, Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with CapriPlus — through 2 ingredients. Tap an ingredient for the detail:
Caprylic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Caprylic Acid + Acebutolol interactionGarlic, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic, Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with CapriPlus — through 2 ingredients. Tap an ingredient for the detail:
Garlic, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic, Powder + Acenocoumarol interactionOil Of OreganoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oil Of Oregano + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with CapriPlus — through 3 ingredients. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Aspirin interactionOil Of OreganoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oil Of Oregano + Acetaminophen, Aspirin interactionCaprylic AcidNonsteroidal Anti-inflammatory Drugs (nsaids) Moderate
Interaction Summary
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
Read the full Caprylic Acid + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with CapriPlus — through 3 ingredients. Tap an ingredient for the detail:
Caprylic AcidNonsteroidal Anti-inflammatory Drugs (nsaids) Moderate
Interaction Summary
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
Read the full Caprylic Acid + Acetaminophen, Aspirin, Caffeine interactionGarlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Aspirin, Caffeine interactionOil Of OreganoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oil Of Oregano + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with CapriPlus — through 1 ingredient. Tap an ingredient for the detail:
Garlic, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CapriPlus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Garlic, Powder
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Caprylic Acid
Antihypertensive Drugs
Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that caprylic acid might have positive inotropic effects, resulting in reduced arterial pressure and vascular resistance and increased cardiac output.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
In vitro research suggests that caprylic acid might displace NSAIDs from binding sites on albumin. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, caprylic acid might increase plasma concentrations of warfarin.
In vitro research suggests that high doses of caprylic acid might displace warfarin from albumin binding sites. This effect has not been reported in humans.
Oil of Oregano
Anticoagulant/Antiplatelet Drugs
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.
Antidiabetes Drugs
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Brand information
Manufacturer and brand details for CapriPlus, from the product label.
Karuna
See all Karuna products- Name
- Karuna Corp.
- Street Address
- 42 Digital Drive #7
- City
- Novato
- State
- CA
- ZipCode
- 94949
CapriPlus by Karuna: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CapriPlus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CapriPlus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Oregano
Interacts with 208 drugsOregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...
Read the full Oregano monograph → Herb & supplement monographCaprylic Acid
Interacts with 262 drugsCaprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While laboratory studies show it has antimicro...
Read the full Caprylic Acid monograph → Herb & supplement monographGarlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph →Sources & How We Checked
CapriPlus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 171 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oregano 12 references
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- Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
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- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
- Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
- McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
- Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
- Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
- Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.
Caprylic Acid 5 references
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- Kristev A, Mitkov D, Lukanov Y, Chapkynov P. The effect of octanoic fatty acid on the cardiovascular system of the guinea pig. Cor Vasa 1989;31(4):321-7.
- Hayball PF, Holman JW, Nation RL. Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. J Chromatogr B Biomed App PubMed
- Noctor TA, Wainer IW, Hage DS. Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. J Chromatogr 1992;5 PubMed
- Voller B, Lines E, McCrossin G, et al. Dose-escalation study of octanoic acid in patients with essential tremor. J Clin Invest. 2016;126(4):1451-7. PubMed
Garlic 154 references
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- McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993;13:406-7. DOI
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- Sunter WH. Warfarin and garlic. Pharm J 1991;246:722.
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