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Dietary supplement

Devil's Claw 1,000 mg Ingredients & Drug Interactions

by Nature's Answer

Devil's Claw 1,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Devil's Claw 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Devil's Claw 1,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis pain, lower back pain, joint pain and stiffness.Based on those ingredients, 804 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw (Harpagophytum procumbens) root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Devil's Claw 1,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Devil's Claw 1,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Devil's Claw 1,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: devil's claw root extract (from Harpagophytum procumbens) at 1,000 mg per serving. Devil's claw has been traditionally used for joint and back pain.

The liquid form includes inactive ingredients—purified water, vegetable glycerin, and certified organic alcohol—that serve as the base and preservative for the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Devil's Claw's overall clinical evidence instead.

Moderate

Some clinical evidence supports Devil's Claw for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Back pain — rated "Possibly Effective" (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Natural Medicines).

Devil's claw is possibly effective for back pain and osteoarthritis, based on the evidence we hold. For atherosclerosis (hardening of the arteries), there isn't enough reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Devil's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Devil's claw is generally well tolerated for short-term use in healthy adults, but digestive upset is common. The most frequent side effects are allergic skin reactions, diarrhea, and indigestion, reported in some trial participants and especially at higher doses—gastrointestinal complaints appeared in about 9% to 18% of people taking specific devil's claw extracts in studies.

Rarely, gastrointestinal bleeding has been reported. A small number of trial participants also experienced headache, ringing in the ears, loss of appetite, loss of taste, dizziness, drowsiness, or sleep trouble, though it's unclear whether devil's claw caused these.

Do not use during pregnancy—the safety data advises against it because it may affect the uterus and safety hasn't been established. Avoid while breastfeeding because there isn't enough information to know if it's safe.

Side effects, ingredient by ingredient Devil's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Devil's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 805 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or any other blood thinners (Moderate interaction). Also double-check any drugs metabolized by CYP2C19, CYP2C9, or CYP3A4 liver enzymes—a broad group including many antidepressants, statins, and blood pressure medications (Moderate).

If you take acid-reducing drugs like famotidine or omeprazole, note that devil's claw may reduce their effectiveness (Minor).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Devil's claw may help with back pain or osteoarthritis, but it can slow how your liver clears certain medications and potentially make them build up to unsafe levels—especially blood thinners like warfarin. If you take any prescription medication, run it through the checker on this page before you start, and talk it over with your doctor or pharmacist.

It's not for use in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Devil's Claw 1,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000002564
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 59152
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Devil's Claw 1,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
083000002564
IngredientAmount% DV
Devil's Claw (Harpagophytum procumbens) root extract1000 mg--

Other ingredients: purified Water, Vegetable Glycerin, certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Gluten Free

K Parve

Bio-Chelated Cold Extraction Process

Formula

K Parve

Harpagophytum procumbens

Low Alcohol

General

9228 Rev. 614

General Statements

Since 1972

Super Concentrated 1,000 mg

Our facility is cGMP certified, organic and kosher certified.

Brand IP Statement(s)

Advanced Botanical Fingerprint

Discover Nature’s Answer

Our organic extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

2014 Nature's Answer

Formulation

Gluten - Free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1 mL (28 drops) 3 times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is seal is damaged or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Devil's Claw 1,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Devil's Claw 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Devil's Claw 1,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Devil's Claw (Harpagophytum procumbens) root extract

Interacts with
804 drugs
1000 mg per serving

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort....

Devil's Claw (Harpagophytum procumbens) root extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, Certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Devil's Claw 1,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Devil's Claw 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
804Drugs
731 Moderate 73 Minor

Ingredients driving the most interactions

Devil's Claw (Harpagophytum procumbens) root extract 804

Individual Drug Interactions

The ingredients in Devil's Claw 1,000 mg interact with 804 drugs. Click any drug to see the details.

1 of the 1 ingredient in Devil's Claw 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw (Harpagophytum procumbens) root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Devil's Claw 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Devil's Claw (Harpagophytum procumbens) root extract7 drug types · 804 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.

Likelihood Possible Evidence D
Devil's Claw (Harpagophytum procumbens) root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Devil's Claw 1,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Devil's Claw 1,000 mg by Nature's Answer: Common Questions

Does Devil's Claw 1,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Devil's Claw 1,000 mg has a known interaction with 804 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Devil's Claw 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—the safety data advises against it during pregnancy because devil's claw may affect the uterus and safety hasn't been established. Avoid while breastfeeding as well, because there isn't enough information to know if it's safe for your baby. Talk with your doctor or pharmacist about alternatives.
What side effects might I notice?
Digestive upset is the most common—diarrhea, indigestion, or stomach discomfort, especially at higher doses. A smaller number of people report headache, ringing in the ears, loss of appetite, or sleep trouble. Rarely, gastrointestinal bleeding has occurred. If you develop any of these, stop taking it and check with your pharmacist or doctor.
Does devil's claw actually work for back pain?
The evidence suggests it's possibly effective for back pain and osteoarthritis, based on the data we hold. That means there's some research backing it, but more studies would help confirm how well it works and for whom.
Why are there so many medication interactions?
Devil's claw may slow how your liver breaks down and clears drugs. Many common medications rely on those same liver enzymes, so the extract can cause those drugs to build up in your bloodstream and potentially become too strong—that's why it's important to check your specific prescriptions before starting.
I take a blood thinner—is this safe?
Probably not without medical oversight. There's a documented case of a patient taking warfarin and devil's claw together who developed unusual bruising, suggesting the blood thinner became overactive. Talk with your doctor before taking this product if you're on any blood thinner.
What's in this liquid form besides the active ingredient?
The inactive ingredients are purified water, vegetable glycerin, and certified organic alcohol, which serve as the base and preservative for the devil's claw extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Devil's Claw 1,000 mg label
Go deeper

The Full Monographs Behind Devil's Claw 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Devil's Claw

Interacts with 804 drugs

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...

Read the full Devil's Claw monograph →
Sources

Sources & How We Checked

Devil's Claw 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Devil's Claw 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  4. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
  5. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
  6. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  9. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
  10. Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
  11. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
  12. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  13. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  14. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  15. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
  16. Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
  17. Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
  18. Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.

See these in context on the Devil's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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