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Dietary supplement

DMAE Sublingual Ingredients & Drug Interactions

by Intensive Nutrition

DMAE Sublingual label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE Sublingual against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE Sublingual is a dietary supplement by Intensive Nutrition with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE-bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE Sublingual by Intensive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE Sublingual by Intensive Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE Sublingual by Intensive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: DMAE-bitartrate (deanol), a compound thought to support acetylcholine, a brain chemical involved in memory and attention. The liquid also contains water, DMSO, glycerol, and peppermint oil as inactive ingredients to deliver the DMAE in sublingual form — meaning you dissolve it under your tongue.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory, focus, and mental clarity support.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Cognitive function, mood, brain health.
  • The closest evidence on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD) (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Cognitive function.

The evidence for DMAE is limited. For Alzheimer disease and tardive dyskinesia (a movement disorder), it's rated likely ineffective.

For aging skin, ADHD, and athletic performance, there's insufficient reliable evidence to say whether it works. The data we hold doesn't support its use for any of these conditions.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Deanol seems to be generally well tolerated when taken by mouth, but side effects are possible and the overall safety evidence is limited. The most common reported side effects are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting.

Other less common side effects include headache, insomnia, confusion, constipation, and skin reactions. At doses above 1000 mg daily, it may cause mood changes including depression or hypomania, especially in people with psychiatric conditions; at 1500 mg daily, it has been reported to worsen schizophrenia symptoms in some patients.

Safety during pregnancy is not established in the data we hold, and the data advises against use while breastfeeding.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take DMAE Sublingual, check with your doctor or pharmacist if you take anticholinergic drugs (medications that dry secretions or reduce nerve signaling in the brain and gut) or cholinergic drugs (medications that enhance nerve signaling). Deanol may theoretically decrease the effect of anticholinergics and increase both the effects and side effects of cholinergics, though these interactions are rated Minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE is not rated effective for its commonly claimed uses like Alzheimer disease or ADHD — the evidence doesn't support it. If you take anticholinergic or cholinergic medications, you'll want to check with your doctor or pharmacist before adding this product, since it may theoretically affect how they work.

Given the limited safety evidence and the possibility of side effects, talk with your healthcare provider about whether it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE Sublingual, straight from the product label.

Brand Intensive Nutrition
Net contents 14 mL; 0.5 oz.
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 23645
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE Sublingual by Intensive Nutrition , sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Drop(s)
Maximum serving Sizes:
5 Drop(s)
IngredientAmount% DV
DMAE-bitartrate50 mg--

Other ingredients: Water, DMAE-bitartrate, DMSO, Glycerol, Peppermint Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Contains 3.7 gram of DMAE-bitartrate belonging to the vitamin-B complex group, in 14 ml DMSO/water solution. Approximately 370 drops/btl.

Suggested/Recommended/Usage/Directions

Directions: Place 2-5 drops under tongue or as directed by a health professional

General

#117L

General Statements

Made in USA

Formulation

NO PRESERVATIVES

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE Sublingual by Intensive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE Sublingual label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE Sublingual by Intensive Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Drop(s) Dosage formLiquid Amounts shown are per serving.

DMAE-bitartrate

Interacts with
219 drugs
50 mg per serving Form: DMSO/water solution

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE-bitartrate monograph & interactions

Other (inactive) ingredients: Water, DMAE-bitartrate, DMSO, Glycerol, Peppermint Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE Sublingual by Intensive Nutrition Drug Interactions

Want to check YOUR meds against DMAE Sublingual?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE-bitartrate 219

Individual Drug Interactions

The ingredients in DMAE Sublingual interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE Sublingual interact with drugs. Each result below shows which ingredient is responsible. DMAE-bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE Sublingual with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE-bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE-bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE Sublingual, from the product label.

Intensive Nutrition

See all Intensive Nutrition products
Web Address
www.intensivenutrition.com
Pharmacist Counseling Corner

DMAE Sublingual by Intensive Nutrition : Common Questions

Does DMAE Sublingual by Intensive Nutrition interact with any medications?
Yes. Based on its ingredients, DMAE Sublingual has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE Sublingual contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take DMAE if I'm pregnant or breastfeeding?
Safety data during pregnancy isn't on file for this product. The data advises against use while breastfeeding. Talk with your doctor or pharmacist about whether it's right for your situation — they can weigh the specifics of your pregnancy or breastfeeding plans.
Does DMAE really help with memory or ADHD?
The evidence isn't established for either. For Alzheimer disease it's rated likely ineffective, and for ADHD there's not enough reliable data to say one way or the other. If you're looking to support memory or focus, ask your doctor what the science actually supports.
What are the most common side effects?
Abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting are the side effects most often reported. Other possible effects include headache, insomnia, and constipation, though they're less common.
Can DMAE affect my mood?
Yes — at higher doses (above 1000 mg daily), deanol has been reported to cause mood changes including depression or hypomania, especially in people with existing psychiatric conditions. At 1500 mg daily, it's been reported to worsen schizophrenia symptoms in some patients.
What's the ingredient in this product?
The active ingredient is DMAE-bitartrate, also known as deanol, a compound thought to increase acetylcholine, a brain chemical involved in memory and attention. The liquid carries it in water, glycerol, DMSO, and peppermint oil.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE Sublingual is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE Sublingual label
Go deeper

The Full Monographs Behind DMAE Sublingual’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE Sublingual's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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