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Dietary supplement

GABA Trex Grape Flavored Chewables Ingredients & Drug Interactions

by NS

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

GABA Trex Grape Flavored Chewables is a dietary supplement by NS with 2 active ingredients. Its ingredients are commonly taken for tooth decay prevention, dry mouth, sugar substitute.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of GABA Trex Grape Flavored Chewables by NS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GABA Trex contains two active ingredients. Xylitol is a sugar alcohol used as a sweetener and studied mainly for dental health.

L-theanine is an amino acid found in tea, included here for potential effects on alertness and cognitive function. The product also contains inactive ingredients — stearic acid, citric acid, stevia extract, silica, natural grape flavor, and magnesium stearate — which act as binding and flavoring agents in the chewable tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Relaxation, calm, and stress support.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, Sleep quality, Mental relaxation.
  • The closest evidence on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

Xylitol is likely effective for reducing dental cavities when used regularly. For ear infections (otitis media) and dry mouth, xylitol is possibly effective, though evidence is less robust.

The evidence for Gulf War Syndrome and cystic fibrosis is too thin to rate. L-theanine is possibly effective for supporting cognitive function, but we don't have strong evidence in our data for age-related cognitive decline, Alzheimer's disease, anxiety, OCD, or cancer.

If you're taking this for a specific health goal, the science is strongest for dental cavity prevention.

The evidence, ingredient by ingredient Xylitol Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Xylitol is generally well tolerated in food amounts, but high doses (30–40 grams at once) can cause diarrhea, bloating, and gas. It's toxic to dogs, so keep it away from pets.

L-theanine may cause headaches, drowsiness, or vivid dreams in some people, and long-term safety in humans hasn't been well studied. Pregnancy and breastfeeding data for L-theanine are insufficient — the safety notes advise against using supplements during these times; talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Xylitol Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on blood pressure medications (antihypertensives) — L-theanine may enhance their effect and lower your blood pressure further. Also clear it if you use sedatives, sleep aids, or other CNS depressants, or if you take antidepressants or anti-anxiety medications (serotonergic drugs), all of which may have additive effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work for dental health and possibly for attention, but the bigger question is medication interactions. If you take blood pressure medication, sedatives, or antidepressants, you'll want to check with your doctor or pharmacist first — L-theanine can potentially affect how they work.

For pregnancy and breastfeeding, the data just isn't there, so discuss it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA Trex Grape Flavored Chewables, straight from the product label.

Brand NS
Barcode (UPC) 659468101455
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267644
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA Trex Grape Flavored Chewables by NS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
659468101455
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Xylitol2 Gram(s)--
Total Sugars0 Gram(s)--
L-Theanine200 mg--

Other ingredients: Stearic Acid, Citric Acid, Stevia extract, Silica, natural Grape flavor, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Chew 1-2 tablets up to three times daily or as directed by your healthcare provider. Do not exceed suggested use.

Precautions

Do not exceed suggested use. This product has a tamper evident seal under the cap. Do not use if seal is broken or missing.

If you are pregnant or nursing, consult your healthcare provider before use.

Keep out of reach of children.

Storage

Store at room temperature, in a dry place.

General Statements

NeuroScience Quality Consistent products, consistent results. Scan to learn more.

FDA Statement of Identity

Dietary Supplement

Formulation

Serotonin/GABA

Not a significant source of added sugars.

See for yourself

GABA Trex Grape Flavored Chewables by NS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in GABA Trex Grape Flavored Chewables by NS

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Xylitol

No known
interactions
2 Gram(s) per serving

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or loz...

Xylitol monograph & interactions

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Other (inactive) ingredients: Stearic Acid, Citric Acid, Stevia extract, Silica, Natural Grape flavor, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

GABA Trex Grape Flavored Chewables by NS Drug Interactions

Want to check YOUR meds against GABA Trex Grape Flavored Chewables?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
565Drugs
172 Moderate 393 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA Trex Grape Flavored Chewables with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
The maker

Brand information

Manufacturer and brand details for GABA Trex Grape Flavored Chewables, from the product label.

NS

See all NS products
Name
NeuroScience
City
Osceola
State
WI
ZipCode
54020
Phone Number
1-888-342-7272
Web Address
www.neuroscienceinc.com
Pharmacist Counseling Corner

GABA Trex Grape Flavored Chewables by NS: Common Questions

Does GABA Trex Grape Flavored Chewables by NS interact with any medications?
Yes. Based on its ingredients, GABA Trex Grape Flavored Chewables has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA Trex Grape Flavored Chewables contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
The safety data for L-theanine during pregnancy and breastfeeding are too limited to say it's safe. Our facts advise against using this supplement during these times. Talk with your doctor or pharmacist about what's right for your situation.
Can xylitol really prevent cavities?
Yes — xylitol is likely effective at reducing dental cavities with regular use. That's the strongest evidence for any ingredient in this product.
Will this make me drowsy?
L-theanine may cause drowsiness or vivid dreams in some people, though it's not guaranteed. If you're sensitive to sedating effects, start cautiously and watch how you feel.
Is there a limit to how much xylitol I can take?
High doses of xylitol — around 30 to 40 grams at once — can trigger diarrhea, bloating, and gas. Normal food amounts are fine, but if you're taking a supplement dose, discuss it with your doctor.
Will this help with anxiety?
The evidence for L-theanine and anxiety isn't strong enough in our data to say whether it works. If anxiety is your main concern, talk with your doctor about proven options.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GABA Trex Grape Flavored Chewables is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA Trex Grape Flavored Chewables label
Sources

Sources & How We Checked

GABA Trex Grape Flavored Chewables's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Xylitol 7 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
  3. Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. PubMed
  4. Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620.
  5. Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. PubMed
  6. Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. PubMed
  7. Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. PubMed

See these in context on the Xylitol monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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