Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

MacuGuard Ingredients & Drug Interactions

by Life Extension

MacuGuard label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MacuGuard against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MacuGuard is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 892 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are natural Astaxanthin, Marigold extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MacuGuard by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with MacuGuard by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of MacuGuard by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 6 active ingredients.
  • “Marigold extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “MacuGuard Carotenoid Phospholipid Blend” is a proprietary blend — the label gives one combined amount (145 mg) without saying how much of each component you get.

MacuGuard has 6 active ingredients designed to support eye health, mainly carotenoids (pigments that accumulate in the macula of the eye). You get zeaxanthin in two forms—meso-zeaxanthin and trans-zeaxanthin—plus free lutein, natural astaxanthin, and extracts from marigold and a proprietary carotenoid-phospholipid blend.

The product also contains inactive ingredients like olive oil, gelatin, safflower oil, and beeswax to form the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

For age-related macular degeneration (AMD), the main reason people take this supplement, both zeaxanthin and lutein are rated possibly effective. The evidence suggests they may help, but it's not definitive.

For other uses listed in the data—cognitive decline, Alzheimer disease, asthma, cancer, and several others—the evidence we hold is insufficient to rate whether these ingredients work. Astaxanthin's effectiveness for any of its studied uses is also not established in our data.

The evidence, ingredient by ingredient Astaxanthin Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin and lutein from the supplement are generally well tolerated at typical doses. Lutein at up to 20 mg daily hasn't caused adverse effects in the studies we hold.

Astaxanthin is also generally well tolerated in short-term studies, though long-term safety data are limited; the main side effects reported are abdominal pain, diarrhea, and red-colored stools at higher doses (40 mg daily). For pregnancy and breastfeeding: zeaxanthin and lutein are rated likely safe, but the data advise caution with supplements during pregnancy and breastfeeding since concentrated supplement safety hasn't been well studied—dietary amounts from food are fine.

Astaxanthin is different: the safety data advise against use during both pregnancy and breastfeeding due to lack of evidence. We hold no pregnancy/breastfeeding data for phospholipids or C3G.

Side effects, ingredient by ingredient Astaxanthin Calendula

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Astaxanthin, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 752 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MacuGuard, check if you're on antidiabetes drugs—zeaxanthin may theoretically increase low blood sugar risk. Also double-check any medications metabolized by CYP3A4 or CYP2B6 liver enzymes (a large group including many blood pressure, cholesterol, and other common drugs), since astaxanthin may lower their levels.

Use the medication checker below with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

MacuGuard is designed for people concerned about age-related eye health, particularly macular degeneration. If you take diabetes medications, drugs metabolized by liver enzymes like CYP3A4 or CYP2B6, or are pregnant or breastfeeding (especially with astaxanthin), check with your pharmacist first.

The ingredient list is solid and generally well tolerated, but the interaction and pregnancy data mean a quick conversation is worth it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MacuGuard, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870192763
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60783
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MacuGuard by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
737870192763
IngredientAmount% DV
Phospholipids0 NP--
Meso-Zeaxanthin4 mg--
Trans-Zeaxanthin0 NP--
Marigold extract0 NP--
natural Astaxanthin6 mg--
Free Lutein10 mg--
C3G2.2 mg--
MacuGuard Carotenoid Phospholipid Blend145 mg--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, Safflower Oil, purified Water, Beeswax, Annatto color, Potato Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Based on scientific studies, this formula is enhanced with phospholipids to increase lutein absorption.*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) softgel daily with or without food, or as recommended by a healthcare practitioner.

Precautions

WARNINGS: -Keep out of reach of children.

-DO NOT EXCEED RECOMMENDED DOSE. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

LuteinPlus and Mz are registered trademarks of Nutriproducts Ltd., UK, licensed under U.S. Patent 8,623,428.

General

Q01927A

Formula

Ocular Support* with Astaxanthin

Carotenoid Blend of Lutein, Zeaxanthin and C3G plus Astaxanthin

FDA Statement of Identity

Dietary Supplement

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MacuGuard by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MacuGuard label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MacuGuard by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Natural Astaxanthin

Interacts with
671 drugs
6 mg per serving Form: Haematococcus pluvialis algae

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Natural Astaxanthin monograph & interactions

C3G

2.2 mg per serving Form: European Black Currant extract

MacuGuard Carotenoid Phospholipid Blend

145 mg per serving

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Safflower Oil, Purified Water, Beeswax, Annatto color, Potato Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

MacuGuard by Life Extension Drug Interactions

Want to check YOUR meds against MacuGuard?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
892Drugs
751 Moderate 141 Minor

Ingredients driving the most interactions

natural Astaxanthin 671
Marigold extract 248

Individual Drug Interactions

The ingredients in MacuGuard interact with 892 drugs. Click any drug to see the details.

2 of the 4 ingredients in MacuGuard interact with drugs. Each result below shows which ingredient is responsible. natural Astaxanthin Marigold extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MacuGuard with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

natural Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
natural Astaxanthin full monograph & interactions

Marigold extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Marigold extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MacuGuard, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

MacuGuard by Life Extension: Common Questions

Does MacuGuard by Life Extension interact with any medications?
Yes. Based on its ingredients, MacuGuard has a known interaction with 892 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MacuGuard contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this supplement work for age-related macular degeneration?
Zeaxanthin and lutein—two of the main ingredients here—are both rated possibly effective for AMD. That means there's evidence they may help, but it's not definitive proof. Talk to your eye doctor about whether adding this supplement fits your specific situation.
Is it safe to take if I'm pregnant or breastfeeding?
Zeaxanthin and lutein are rated likely safe in pregnancy and breastfeeding, but the caution is that concentrated supplement safety hasn't been thoroughly studied—eating these carotenoids in food is fine. Astaxanthin is different: the data advise against it during both pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are the side effects I might see?
Most people tolerate this supplement well. Astaxanthin—one of the active ingredients—can cause abdominal pain, diarrhea, or red-colored stools, especially at higher doses. These are uncommon at typical supplement amounts, but if you notice them, let us know.
What is lutein and why is it in here?
Lutein is a yellow carotenoid pigment that collects in the macula—the center of the retina—and protects it from light damage. It's rated possibly effective for both age-related macular degeneration and cataracts, which is why supplement makers include it in eye-health products.
Can I take this with my diabetes medication?
Possibly, but check first. Zeaxanthin in this product has theoretically lowered blood sugar in animal studies, and combining it with antidiabetes drugs might increase the risk of low blood sugar. Use the medication checker on this page with your exact drug name, or ask your pharmacist before starting.
Are there any fillers or artificial ingredients I should know about?
The inactive ingredients are natural and common: olive oil, gelatin, safflower oil, glycerin, beeswax, purified water, and a potato-based thickener. There's no corn starch, soy, or gluten listed in the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MacuGuard is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MacuGuard label
Go deeper

The Full Monographs Behind MacuGuard’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph →
Sources

Sources & How We Checked

MacuGuard's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team