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Dietary supplement

Pure Tranquility Liquid Ingredients & Drug Interactions

by Pure Encapsulations

Liquid Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pure Tranquility Liquid is a dietary supplement by Pure Encapsulations with 3 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Suntheanine, GABA, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pure Tranquility Liquid by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Tranquility Liquid contains three active ingredients. Glycine is an amino acid; theanine (sold as Suntheanine) is a compound from green tea thought to support relaxation; and GABA is a neurotransmitter involved in calming effects.

The product also contains inactive ingredients—water, glycerin, cane sugar, citric acid, natural apple flavor, potassium sorbate, and stevia leaf extract—that serve as the base, sweetener, and preservative.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: relaxation and calm support.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress, Depression, Post-traumatic stress disorder (PTSD) — and 4 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Depression, Insomnia, Stress, Psychological well-being, and more.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

The evidence for these ingredients is mixed. Glycine is rated possibly effective for schizophrenia but has insufficient evidence for ADHD, benign prostatic hyperplasia, and cystic fibrosis.

Theanine is rated possibly effective for cognitive function but insufficient evidence exists for anxiety, Alzheimer disease, and cancer. GABA has insufficient evidence to rate it for anxiety, ADHD, athletic performance, and other conditions.

In short, the scientific support for this product's calming or cognitive effects isn't well established in the data we hold.

The evidence, ingredient by ingredient Glycine Theanine Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three ingredients are generally well tolerated at typical doses, but long-term safety data are limited for each. Glycine rarely causes mild sedation, irritability, insomnia, fatigue, memory impairment, headache, soft stools, nausea, vomiting, and upper GI discomfort—these resolve quickly if you stop taking it.

Theanine may cause headaches, drowsiness, increased sleep, and increased dream activity. GABA most commonly causes drowsiness, gastric upset, minor throat burning, muscle weakness, and nausea.

For pregnancy and breastfeeding, the data on all three ingredients is insufficient—there isn't enough information to know whether they're safe, so you should talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Glycine Theanine Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Theanine, Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pure Tranquility Liquid, double-check with your doctor or pharmacist if you take clozapine (Clozaril)—adding this product could worsen schizophrenia symptoms. Also check if you're on blood pressure medications or CNS depressants (sedatives, sleep aids, certain pain relievers), since the product's ingredients may intensify their effects.

If you take antidepressants or other serotonergic drugs, mention this product as well, though reported problems are rare.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pure Tranquility Liquid is best considered if you're looking to support relaxation or cognitive focus, though the scientific evidence for its effectiveness is limited. It's not a good choice if you take clozapine, blood pressure medications, or CNS depressants without checking first—these interactions matter.

If you're pregnant or breastfeeding, or take any prescription medications, talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Tranquility Liquid, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298014289
Net contents 116 Milliliter(s); 3.92 Fluid Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294045
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Tranquility Liquid by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 mL
Maximum serving Sizes:
4 mL
Servings per container
29
UPC/BARCODE
766298014289
IngredientAmount% DV
Glycine50 mg--
Suntheanine100 mg--
GABA100 mg--

Other ingredients: Water, Purified, Glycerin, Natural, Cane Sugar, Evaporated, Citric Acid, Natural Apple Flavor, Potassium Sorbate, Stevia Leaf Extract, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement take 4 ml (4 full droppers), 1-2 times daily, between meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition are are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Brand IP Statement(s)

Suntheanine is a registered trademark of Taiyo International, Inc.

General Statements

Scan to learn about our hypoallergenic supplements Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization)

Formulation

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Supports relaxation

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Pure Tranquility Liquid by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pure Tranquility Liquid by Pure Encapsulations

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 mL Dosage formLiquid Servings per container29 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
50 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Suntheanine

Interacts with
565 drugs
100 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

GABA

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

Other (inactive) ingredients: Water, Purified, Glycerin, Natural, Cane Sugar, Evaporated, Citric Acid, Natural Apple Flavor, Potassium Sorbate, Stevia Leaf Extract, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Tranquility Liquid by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Pure Tranquility Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
565Drugs
173 Moderate 392 Minor

Ingredients driving the most interactions

GABA 419

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Tranquility Liquid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
The maker

Brand information

Manufacturer and brand details for Pure Tranquility Liquid, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Pure Tranquility Liquid by Pure Encapsulations: Common Questions

Does Pure Tranquility Liquid by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Pure Tranquility Liquid has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Tranquility Liquid contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take with my blood pressure medication?
Both theanine and GABA in this product may lower blood pressure, so combining them with your medication could drop your blood pressure more than intended. Talk with your doctor or pharmacist before taking it—they can decide if it's safe for you or if dosing needs adjustment.
What does each ingredient in this product do?
Glycine is an amino acid thought to support calmness; theanine is a compound from green tea linked to relaxation and focus; and GABA is a brain chemical involved in calming effects. Together, they're marketed for tranquility, though the evidence isn't strong.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data on any of these three ingredients to know whether they're safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist—they can help you decide what's right for you and your baby.
What side effects might I experience?
Mild sedation, irritability, insomnia, headache, soft stools, nausea, and drowsiness have been reported—though most are rare and resolve when you stop taking it. Some people also report headaches or increased dreaming with theanine.
Does this product actually help with anxiety?
The scientific evidence for anxiety relief is limited—the data we hold rates it as insufficient to know whether it works. You'd want to discuss it with your doctor, especially since other proven options may be available.
Can I take this with sleep aids or sedatives?
Theoretically, the sedative ingredients in this product could add to the effects of sleep aids or sedatives, though we don't have clear proof that this matters in practice. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Tranquility Liquid is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Tranquility Liquid label
Sources

Sources & How We Checked

Pure Tranquility Liquid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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