Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

RePlenish Ingredients & Drug Interactions

by Bronson Laboratories

RePlenish label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RePlenish against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

RePlenish is a dietary supplement by Bronson Laboratories with 6 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 1,146 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are t-Resveratrol, Alpha Lipoic Acid, Acetyl L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against RePlenish by Bronson Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with RePlenish by Bronson Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of RePlenish by Bronson Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

RePlenish contains six active ingredients. Alpha-lipoic acid is an antioxidant that may help with nerve damage from diabetes and cholesterol levels.

Acetyl-L-carnitine supports brain health and nerve function. Biotin, a B vitamin, plays a role in hair, skin, and nail health.

Vitamin B12 is essential for nerve function, energy, and red blood cell formation. CoQ10 is a compound your body makes naturally and is involved in energy production and heart health.

Resveratrol is a plant compound with antioxidant properties that may support cardiovascular and metabolic health. The product also contains inactive ingredients—modified cellulose, microcrystalline cellulose, stearic acid, magnesium stearate, and silicon dioxide—which serve as binders, fillers, and flow agents in the capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports cellular health and overall well-being.
  • We looked for evidence on: Age-related cognitive decline, Aging, Aging skin, Alzheimer disease, Atherosclerosis, Biotin deficiency — and 4 related terms.
  • The strongest evidence on file: Biotin is rated "Likely Effective" for Biotin deficiency (Natural Medicines).
  • Also on file: Acetyl-l-carnitine is rated "Possibly Effective" for Age-related cognitive decline, Alzheimer disease.
  • Also on file: Resveratrol is rated "Possibly Ineffective" for Cardiovascular disease (CVD).

The evidence for these ingredients varies. Alpha-lipoic acid is possibly effective for diabetic nerve pain and high cholesterol, and possibly effective for weight support.

Acetyl-L-carnitine is possibly effective for age-related cognitive decline, Alzheimer disease, nerve damage from diabetes, depression, and alcohol use disorder. Biotin is likely effective if you have a biotin deficiency; for other uses like multiple sclerosis and scalp dermatitis the evidence suggests it's not effective.

Vitamin B12 is effective for B12 deficiency and likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain after shingles. CoQ10 is likely effective if you're deficient in it, and possibly effective for heart failure, migraines, diabetic nerve pain, and fibromyalgia.

Resveratrol is possibly effective for weight support and hay fever, but the evidence suggests it's not effective for heart disease or high cholesterol. The strength of evidence varies across these uses—talk with your pharmacist about whether any of these match what you're looking to address.

The evidence, ingredient by ingredient Alpha-lipoic Acid Acetyl-l-carnitine Biotin Vitamin B12 Coenzyme Q10 Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Overall, these ingredients are generally well tolerated at typical doses. Alpha-lipoic acid can lower blood sugar and is best used under medical guidance; common side effects include headache, heartburn, nausea, and vomiting, and skin rash or itching have been reported.

Acetyl-L-carnitine is well tolerated short-term, though long-term safety isn't fully established; it may cause agitation, dry mouth, headache, insomnia, reduced appetite, or a fishy odor in urine and breath. Biotin is very safe even at high doses.

Vitamin B12 is safe and has no established upper limit; it's needed in pregnancy and breastfeeding. CoQ10 is generally well tolerated, with rare gastrointestinal upset in less than 1% of users.

Resveratrol at typical doses is well tolerated, though high doses may cause diarrhea and digestive upset. For pregnancy and breastfeeding: there isn't enough safety data for alpha-lipoic acid, so it's best avoided during pregnancy and breastfeeding unless your doctor advises otherwise.

Acetyl-L-carnitine should also be avoided in pregnancy and breastfeeding due to insufficient data. Biotin from food and prenatal vitamins is appropriate, but check with your doctor before high-dose supplements.

Vitamin B12 is needed and safe at recommended amounts during both pregnancy and breastfeeding. CoQ10 and resveratrol lack sufficient pregnancy data, so discuss them with your doctor first.

If you're pregnant or nursing, talk with your OB or pharmacist before starting any new supplement.

Side effects, ingredient by ingredient Alpha-lipoic Acid Acetyl-l-carnitine Biotin Vitamin B12 Coenzyme Q10 Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Resveratrol, Alpha-lipoic Acid, Acetyl-l-carnitine, Vitamin B12, Coenzyme Q10.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 1,147 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start RePlenish, double-check these medications with your pharmacist: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel) due to moderate risk of increased bleeding; chemotherapy drugs, especially alkylating agents and antitumor antibiotics, because the antioxidants here might reduce their effectiveness; thyroid replacement hormone, which both alpha-lipoic acid and acetyl-L-carnitine may weaken; antidepressants and other serotonergic drugs, which acetyl-L-carnitine may interact with; and metformin, which can lower your B12 levels anyway. Resveratrol may also affect how your body clears drugs metabolized by liver enzymes CYP2C19, CYP1A2, CYP3A4, and CYP2E1—your pharmacist can check whether any of your medications fall into these categories.

If you're on antihypertensive drugs for blood pressure, mention this product so they can monitor your readings.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

RePlenish may be worth considering if you're interested in supporting nerve health, cognitive function, or antioxidant status—and if you don't take blood thinners, thyroid medication, chemotherapy, or antidepressants. If you do take any of those, or metformin for diabetes, check your specific medications with our tool first and talk to your pharmacist before starting.

For pregnant or nursing parents, discuss this product with your doctor before use. Overall, chat with your pharmacist to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RePlenish, straight from the product label.

Brand Bronson Laboratories
Barcode (UPC) 716563563011
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298905
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RePlenish by Bronson Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
716563563011
IngredientAmount% DV
Alpha Lipoic Acid500 mg--
Acetyl L-Carnitine900 mg--
Biotin2000 mcg6667%
Vitamin B1230 mcg1250%
CoQ1030 mg--
t-Resveratrol10 mg--

Other ingredients: Modified Cellulose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports cellular health and overall well-being

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take 3 capsules daily or as directed by a health professionals.

Precautions

Warning: Do not take this product if you are pregnant or nursing.

Keep out of reach of children.

Storage

Store at room temperature. Protect from light.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Bronson Discover the Bronson Difference

General Statements

For information call 1-800-235-3200

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RePlenish by Bronson Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RePlenish label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RePlenish by Bronson Laboratories

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha Lipoic Acid

Interacts with
263 drugs
500 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Acetyl L-Carnitine

Interacts with
203 drugs
900 mg per serving

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl L-Carnitine monograph & interactions

Biotin

No known
interactions
2000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Vitamin B12

Interacts with
20 drugs
30 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

CoQ10

Interacts with
198 drugs
30 mg per serving Form: Ubiquinone

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

CoQ10 monograph & interactions

T-Resveratrol

Interacts with
822 drugs
10 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

T-Resveratrol monograph & interactions

Other (inactive) ingredients: Modified Cellulose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

RePlenish by Bronson Laboratories Drug Interactions

Want to check YOUR meds against RePlenish?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,146Drugs
932 Moderate 214 Minor

Ingredients driving the most interactions

t-Resveratrol 822
Alpha Lipoic Acid 263
Acetyl L-Carnitine 203
CoQ10 198
Vitamin B12 20

Individual Drug Interactions

The ingredients in RePlenish interact with 1,146 drugs. Click any drug to see the details.

5 of the 6 ingredients in RePlenish interact with drugs. Each result below shows which ingredient is responsible. t-Resveratrol Alpha Lipoic Acid Acetyl L-Carnitine CoQ10 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in RePlenish with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

t-Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
t-Resveratrol full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Acetyl L-Carnitine4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl L-Carnitine full monograph & interactions

CoQ103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
CoQ10 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RePlenish, from the product label.

Bronson Laboratories

Name
Bronson Laboratories
City
Lindon
State
UT
ZipCode
84042
Phone Number
1-800-235-3200
Pharmacist Counseling Corner

RePlenish by Bronson Laboratories: Common Questions

Does RePlenish by Bronson Laboratories interact with any medications?
Yes. Based on its ingredients, RePlenish has a known interaction with 1,146 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RePlenish contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No, not without checking with your pharmacist first. Alpha-lipoic acid and resveratrol may increase your bleeding risk, and both acetyl-L-carnitine and CoQ10 may reduce how well warfarin works. This is a serious interaction—your pharmacist needs to review your exact medication before you start.
What's the most common side effect I might notice?
It depends on which ingredient affects you most. Alpha-lipoic acid commonly causes headache, heartburn, or nausea. Acetyl-L-carnitine may cause agitation, dry mouth, or headache. CoQ10 rarely causes mild digestive upset in less than 1% of people. Resveratrol at higher doses may cause diarrhea. Most users tolerate the product well.
Is this safe to take while I'm pregnant or breastfeeding?
There isn't enough safety data for most of these ingredients during pregnancy or breastfeeding. Alpha-lipoic acid and acetyl-L-carnitine should be avoided unless your doctor says otherwise. Vitamin B12 is safe and needed. Biotin from food and prenatal vitamins is fine, but ask your doctor about high-dose versions. Talk with your OB or pharmacist for personalized advice.
Will this help with nerve pain from diabetes?
Alpha-lipoic acid, acetyl-L-carnitine, and CoQ10 are all possibly effective for diabetic nerve pain based on the evidence we have. That said, results vary, and you should still check with your doctor about whether this product is right for your specific situation.
Does this product contain any fillers?
Yes, it does. The inactive ingredients are modified cellulose, microcrystalline cellulose, stearic acid, magnesium stearate, and silicon dioxide. These are standard binders and flow agents used in capsules.
Can I take this with my metformin for diabetes?
Metformin can lower your B12 levels over time, and this product contains B12, which is a minor documented interaction. Taking B12 alongside metformin is actually helpful in many cases, but mention it to your pharmacist so they're aware and can monitor your levels if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RePlenish label
Go deeper

The Full Monographs Behind RePlenish’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph → Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

RePlenish's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 168 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
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See these in context on the Coenzyme Q10 monograph →

Resveratrol 24 references
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See these in context on the Resveratrol monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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