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Dietary supplement

Rhodiola Force 100 Ingredients & Drug Interactions

by New Chapter

Rhodiola Force 100 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rhodiola Force 100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rhodiola Force 100 is a dietary supplement by New Chapter with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,271 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola (Rhodiola rosea) (root) hydroethanolic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rhodiola Force 100 by New Chapter

Ask about any prescription or over-the-counter medication and we check it for interactions with Rhodiola Force 100 by New Chapter — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rhodiola Force 100 by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Rhodiola Force 100 contains one active ingredient: rhodiola (Rhodiola rosea) root extract, prepared using a hydroethanolic extraction method. The capsule also includes inactive ingredients — ground rice and hypromellose (the capsule material itself) — which serve as fillers and binders but play no active role.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rhodiola's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: stamina, endurance and well-being under stress.
  • We looked for evidence on: Stress, Fatigue, Athletic performance, Chronic fatigue syndrome (CFS), Depression, Generalized anxiety disorder (GAD) — and 2 related terms.
  • The closest evidence on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Depression, Fatigue, and more.

The evidence we hold for rhodiola doesn't yet establish its effectiveness for the conditions listed — altitude sickness, generalized anxiety disorder (GAD), heart rhythm problems (arrhythmia), athletic performance, and bladder cancer all show insufficient reliable evidence to rate. This means studies so far haven't been robust enough to draw firm conclusions.

If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Rhodiola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rhodiola is generally well tolerated for short-term use, though long-term safety hasn't been thoroughly studied. The most common side effects reported are dizziness and changes in saliva production — either dry mouth or excessive saliva.

The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information yet to know it's safe in those situations — talk with your doctor or pharmacist before taking it if you're pregnant or nursing.

Side effects, ingredient by ingredient Rhodiola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rhodiola.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,272 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Rhodiola Force 100, double-check with your doctor or pharmacist if you're on blood pressure medications (antihypertensive drugs), drugs processed by your liver's CYP2C9 enzyme, or blood sugar medications (antidiabetes drugs). You should also confirm it's okay if you take immunosuppressive medications or any drug reliant on P-glycoprotein transport.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Rhodiola Force 100 might appeal to you if you're interested in an adaptogenic herb and have no blood pressure or diabetes medications on board. However, if you take any blood pressure drugs, blood sugar medications, or drugs processed by your liver's CYP2C9 system, check with your doctor or pharmacist first — the interactions could be significant.

This product is not advised during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rhodiola Force 100, straight from the product label.

Brand New Chapter
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183414
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rhodiola Force 100 by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Rhodiola (Rhodiola rosea) (root) hydroethanolic extract100 mg--

Other ingredients: ground Rice, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Discover the force of the Whole

New Chapter delivers the wisdom of whole food.

2016 New Chapter, Inc.

Formula

Rhodiola rosea is an exalted herbal stress “adaptogen” that supports stamina, endurance and well-being under conditions of exertion and sleep disruption. The full spectrum of beneficial compounds found in Rhodiola Force 100 is delivered using a whole-food approach to herbal supplementation. Rhodiola modulates physiologic stress reactions by shifting the body’s stress response, thereby uplifting mood.

Full-Spectrum Rhodiola promotes overall mental health and stamina

OU

General Statements

Our full-spectrum process extracts precious plant compounds to preserve Nature’s full complexity, delivering super-pure, super-potent herbal extracts.

Full-Spectrum Extraction: Our Difference Many companies isolate elements from an herb, concentrate them, and label it “whole herb.”

Using only natural supercritical CO2 or traditional techniques of extraction, our Force extracts guarantee the fullest spectrum of beneficial phytonutrients in their natural profile.

Please recycle this bottle after use.

Get the Whole Truth! Sign up for our e-newsletter at newchapter.com/newsletter

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

4503-D02

Formulation

Non-GMO verified formula

Gluten free; 100% vegetarian; no artificial flavors or colors.

Gluten free; 100% vegetarian; no artificial flavors or colors.

Seals/Symbols

Non GMO Project Verified 100% Vegetarian Product

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule daily, preferably 30 minutes before breakfast.

Precautions

Caution: As with any dietary or herbal supplement, you should advise your healthcare practitioner of the use of this product.

If you are nursing, pregnant, or considering pregnancy, you should consult your healthcare practitioner prior to using this product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rhodiola Force 100 by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rhodiola Force 100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rhodiola Force 100 by New Chapter

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Rhodiola (Rhodiola rosea) (root) hydroethanolic extract

Interacts with
1,271 drugs
100 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola (Rhodiola rosea) (root) hydroethanolic extract monograph & interactions

Other (inactive) ingredients: Ground Rice, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rhodiola Force 100 by New Chapter Drug Interactions

Want to check YOUR meds against Rhodiola Force 100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,271Drugs
625 Moderate 646 Minor

Ingredients driving the most interactions

Rhodiola (Rhodiola rosea) (root) hydroethanolic extract 1,271

Individual Drug Interactions

The ingredients in Rhodiola Force 100 interact with 1,271 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rhodiola Force 100 interact with drugs. Each result below shows which ingredient is responsible. Rhodiola (Rhodiola rosea) (root) hydroethanolic extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Rhodiola Force 100 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola (Rhodiola rosea) (root) hydroethanolic extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola (Rhodiola rosea) (root) hydroethanolic extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rhodiola Force 100, from the product label.

New Chapter

See all New Chapter products
Name
New Chapter, Inc.
Street Address
90 Technology Dr.
City
Brattleboro
State
VT
ZipCode
05301
Phone Number
888-874-4461
Pharmacist Counseling Corner

Rhodiola Force 100 by New Chapter: Common Questions

Does Rhodiola Force 100 by New Chapter interact with any medications?
Yes. Based on its ingredients, Rhodiola Force 100 has a known interaction with 1,271 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rhodiola Force 100 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does rhodiola in this product actually do?
Rhodiola is an adaptogenic herb — its role is to help your body respond to stress. However, the evidence we hold doesn't yet confirm it works for specific conditions like anxiety, athletic performance, or altitude sickness. If you're considering it for a particular reason, it's worth discussing with your doctor whether the current research supports that use.
Can I take this while pregnant or breastfeeding?
The safety data advises against both. There isn't enough information yet to know whether rhodiola is safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What are the most common side effects?
Dizziness and changes in saliva production — either dry mouth or excessive saliva. These tend to be mild, and rhodiola is generally well tolerated for short-term use.
Is this safe to take long-term?
Short-term safety is established, but long-term safety hasn't been thoroughly studied. If you're thinking about taking this regularly for months or longer, check with your doctor or pharmacist about what we know and don't know over time.
Will this interact with my blood pressure medication?
Possibly. Rhodiola can theoretically lower blood pressure further, which could cause excessively low blood pressure. If you take any blood pressure medication, talk with your doctor or pharmacist before starting this product — they can confirm whether it's safe for you.
Can this affect my blood sugar medication?
Theoretically yes. Rhodiola may lower blood glucose, so taking it alongside diabetes medications could raise the risk of low blood sugar. Confirm with your doctor or pharmacist before starting if you take any blood sugar medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rhodiola Force 100 label
Go deeper

The Full Monographs Behind Rhodiola Force 100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph →
Sources

Sources & How We Checked

Rhodiola Force 100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
  13. Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed

See these in context on the Rhodiola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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