Sage Leaf Extract 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sage Leaf Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sage Leaf Extract 500 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for sore throat and mouth irritation, digestive upset, excessive sweating.Based on those ingredients, 1,296 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sage Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sage Leaf Extract 500 mg by Nature's Answer
Ask about any prescription or over-the-counter medication and we check it for interactions with Sage Leaf Extract 500 mg by Nature's Answer — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sage Leaf Extract 500 mg by Nature's Answer
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Sage Leaf Extract at 500 mg per dose. Sage leaf is the source of the compound, and this extract form concentrates its active constituents.
The liquid also contains inactive ingredients — purified water, glycerin, and alcohol — which help deliver and preserve the extract.
Does it work?
Moderate evidence
Sage extract has possibly effective evidence for menopausal symptoms, elevated cholesterol (hyperlipidemia), and cognitive function. For postoperative pain, the evidence suggests it's possibly ineffective.
The data we hold doesn't establish strong proof for any of these uses, so results vary from person to person.
How safe is it?
Well-documented data
Sage is generally well tolerated as a food or short-term tea, but this is a concentrated extract — use it cautiously. The most common side effects from oral use are abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting.
Rarely, seizures have been associated with thujone, camphor, and cineol compounds in sage. One trial participant developed acneiform skin eruptions (acne-like bumps).
Avoid medicinal or concentrated amounts during pregnancy because of thujone content; ordinary food amounts of sage are likely fine. During breastfeeding, avoid medicinal amounts — sage has traditionally been used to reduce milk supply, so check with your doctor first.
Meds to double-check
Moderate interaction found
Check with a pharmacist before using this product if you take sedatives or CNS depressants, blood pressure medications, medications broken down by the liver (CYP3A4, CYP2D6, CYP2C19, CYP2C9), hormone therapy or estrogens, or any drug transported by P-glycoprotein. The interactions are theoretical so far in humans, but they're consistently documented in lab research.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Sage extract may help with hot flashes, high cholesterol, or memory, but the evidence is moderate and not established for everyone. If you take sedatives, blood pressure drugs, or any medication your body metabolizes through the liver, you'll need to check your specific drugs with a pharmacist before starting.
Talk to your pharmacist or doctor, especially if you're pregnant, breastfeeding, or have seizure concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sage Leaf Extract 500 mg, straight from the product label.
| Brand | Nature's Answer |
|---|---|
| Barcode (UPC) | 083000004810 |
| Net contents | 1 Fluid Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 326748 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sage Leaf Extract 500 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sage Leaf Extract | 125 mg | -- |
Other ingredients: Water, Purified, Glycerin, Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Gluten free
Bio-Chelated Cold Extract process
Gluten-free Absolutely no preservatives
Our alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.
Seals/Symbols
K Parve (Kosher)
Formula
K Parve (Kosher)
Salvia officinalis Made from 500 mg Black Sage Leaf per serving Low alcohol
Brand IP Statement(s)
Nature's Answer Since 1972 Discover Nature's Answer
Copyright 2018 Nature's Answer
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary Supplement, take 0.5 mL (14 drops) once a day in a small amount of water. Shake well.
Precautions
Keep out of reach of children.
Warning: Do not use if pregnant or nursing.
Do not use if safety seal is damaged or missing.
General Statements
For product information, call (800)439-2324
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sage Leaf Extract 500 mg by Nature's Answer label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sage Leaf Extract 500 mg by Nature's Answer
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.5 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Sage Leaf Extract
Interacts with1,296 drugs
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some...
Sage Leaf Extract monograph & interactionsOther (inactive) ingredients: Water, Purified, Glycerin, Alcohol. These complete the product’s ingredient list but are not active constituents.
Sage Leaf Extract 500 mg by Nature's Answer Drug Interactions
HelloPharmacist Interaction Report
Sage Leaf Extract by Nature's Answer has documented interactions with a substantial number of medications.
The most serious concern is with CNS depressants (sedatives, sleep aids, anxiety medications) — sage can theoretically increase their sedative effects and side effects.
Read the full breakdown — every affected drug type, severity by severity
Sage may also affect blood pressure medications (antihypertensives) in unpredictable ways: animal research shows it can lower blood pressure, but human studies with Spanish sage suggest it might raise it in some people with high blood pressure. Additionally, sage can theoretically increase levels of drugs that your liver breaks down through several pathways — including CYP3A4, CYP2D6, CYP2C19, and CYP2C9 substrates — as well as medications transported by P-glycoprotein.
These interactions haven't been observed in people yet, but the lab evidence is consistent. There's also a theoretical concern with hormone therapy (estrogens), as one sage constituent shows estrogenic activity in the lab.
Altogether, these interactions span 1,280 individual medications. Before you start this extract, run your exact medications through the checker on this page — especially any sedatives, blood pressure drugs, or medications your doctor's told you have narrow safety margins.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sage Leaf Extract 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sage Leaf Extract 500 mg interact with 1,296 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sage Leaf Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Sage Leaf Extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
Read the full Sage Leaf Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Sage Leaf Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Read the full Sage Leaf Extract + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Sage Leaf Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Sage Leaf Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCns Depressants, Cytochrome P450 2e1 (cyp2e1) Substrates +3 Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractAnticholinergic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticholinergic Drugs +3 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractAnticholinergic Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Anticholinergic Drugs +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Sage Leaf Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Sage Leaf ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Sage Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sage Leaf Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sage Leaf Extract
Anticholinergic Drugs
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Anticonvulsants
Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.
Antidiabetes Drugs
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.
Antihypertensive Drugs
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.
Benzodiazepines
Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.
Cholinergic Drugs
Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Cns Depressants
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.
Estrogens
Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.
P-Glycoprotein Substrates
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Sage Leaf Extract 500 mg, from the product label.
Nature's Answer
See all Nature's Answer products- Name
- Nature's Answer
- Street Address
- 85 Commerce Drive
- City
- Hauppauge
- State
- NY
- ZipCode
- 11788
- Phone Number
- (800) 439-2324
- Web Address
- www.naturesanswer.com
Sage Leaf Extract 500 mg by Nature's Answer: Common Questions
Does Sage Leaf Extract 500 mg by Nature's Answer interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is sage extract safe during pregnancy?
Can I take sage extract while breastfeeding?
What side effects might I experience?
Does sage extract really help with hot flashes?
What's in this liquid besides the sage?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sage Leaf Extract 500 mg is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sage Leaf Extract 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sage Leaf Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
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The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sage 27 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Todorov S, Philianos S, Petkov V, et al. Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol (Bulg) 1984;10:13-20.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
- Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. PubMed
- Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53-9.
- Perry NB, Anderson RE, Brennan NJ, et al. Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54..
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 2011;28:490-500. PubMed
- Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007 Nov;101:350-8.
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
- Perry, N. S., Houghton, P. J., Theobald, A., Jenner, P., and Perry, E. K. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 2000;52(7):895-902.
- Perry, N. S., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis-Balchin, M., Hoult, J. R., Evans, P., Jenner, P., Milligan, S., and Perry, E. K. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's diseas
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Kavvadias, D., Monschein, V., Sand, P., Riederer, P., and Schreier, P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003;69(2):113-117.
- Savelev, S. U., Okello, E. J., and Perry, E. K. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytother Res 2004;18(4):315-324.
- Kennedy, D. O., Pace, S., Haskell, C., Okello, E. J., Milne, A., and Scholey, A. B. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology 2006;31(4):84 PubMed
- Hubbert, M., Sievers, H., Lehnfeld, R., and Kehrl, W. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur
- Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice. Food Chem.Toxicol. 2007;45(3):456-464.
- Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol. 2008;102(5):466-475.
- Mayer, E., Gescheidt-Shoshany, H., and Weltfriend, S. Allergic contact dermatitis caused by Salvia officinalis extract. Contact Dermatitis 2011;64(4):237-238. PubMed
- Halicioglu, O., Astarcioglu, G., Yaprak, I., and Aydinlioglu, H. Toxicity of Salvia officinalis in a newborn and a child: an alarming report. Pediatr.Neurol. 2011;45(4):259-260. PubMed
- Sertoli, A., Fabbri, P., Campolmi, P., and Panconesi, E. Allergic contact dermatitis to Salvia Officinalis, Inula Viscosa and Conyza Bonariensis. Contact Dermatitis 1978;4(5):314-315.
- Vandecasteele K, Ost P, Oosterlinck W, et al. Evaluation of the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytother Res. 2012;26(2):208-13.
- Kianbakht S, Dabaghian FH. Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial. Complement Ther Med. 2013;21(5):441-6. PubMed
- Amini L, Mojab F, Jahanfar S, Sepidarkish M, Raoofi Z, Maleki-Hajiagha A. Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical tr
- Behradmanesh S, Derees F, Rafieian-Kopaei M. Effect of Salvia officinalis on diabetic patients. J Renal Inj Prev. 2013;2(2):51-4.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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