Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tribulus 250 Ingredients & Drug Interactions

by MET-Rx

Tribulus 250 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 250 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 250 is a dietary supplement by MET-Rx with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tribulus 250 by MET-Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 250 by MET-Rx — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Tribulus 250 by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus 250 contains one active ingredient: tribulus, 250 mg per capsule. The capsule also holds several inactive ingredients—rice powder, gelatin, vegetable magnesium stearate, and silica—which are fillers and binders that help hold the formula together.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: men's health and athletic performance.
  • We looked for evidence on: Athletic performance, Male infertility, Erectile dysfunction (ED), Exercise-induced muscle damage, testosterone, libido — and 1 related terms.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Male infertility, Exercise-induced muscle damage.

Tribulus is possibly effective for sexual dysfunction. The evidence for athletic performance is possibly ineffective, meaning it's unlikely to boost strength or endurance.

For benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence yet to know whether it works.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in the short term by healthy adults, though quality and long-term safety data are limited. The most common side effects are mild—abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation—though in one study these complaints occurred at similar rates in people taking tribulus and those taking placebo.

Rare serious effects including liver or kidney injury and seizures have been reported, and there's one case of someone who drank very large amounts of tribulus water and developed kidney failure and seizures that improved after stopping it. Avoid tribulus during pregnancy because it may affect your hormones and safety isn't established.

Also avoid it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tribulus 250, check with your doctor or pharmacist if you take blood pressure medications (antihypertensive drugs), diabetes medications (antidiabetes drugs), or lithium. These Moderate-severity interactions could lower your blood pressure or blood sugar too much, or raise lithium to unsafe levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual function, though evidence is modest. It's not meant for athletic performance.

If you take blood pressure medication, diabetes medication, or lithium, talk with your doctor or pharmacist before starting—tribulus could amplify their effects in ways that need dose adjustment. Pregnant or breastfeeding people should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 250, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560052573
Net contents 90 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 6535
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 250 by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
786560052573
IngredientAmount% DV
Tribulus250 mg--

Other ingredients: Rice powder, Gelatin, Vegetable Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

HERBAL SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adult men, take one (1) capsule one to three times daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

Precautions

KEEP OUT OF REACH OF CHILDREN.

If you are taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: This product is intended for use by men and is not intended for use by women.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT.

Formula

>> Standardized for 40% Saponins

>>> THE REVOLUTIONARY SCIENCE OF MEN'S HEALTH* <<<

General Statements

• Lab-tested for 40% saponins per serving, to help ensure you receive the active components. • An herb traditionally used by bodybuilders and for men’s health, Tribulus Terrestris is the perfect complement to your hard-core training regimen!*

General

5257 03D B5256 HAZ

Brand IP Statement(s)

(C)2010

MET-Rx(R) TRIBULUS 250

Shaping Every Body.(TM)

Formulation

FREE OF: yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5 mg per serving).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 250 by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 250 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 250 by MET-Rx

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Tribulus

Interacts with
259 drugs
250 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus monograph & interactions

Other (inactive) ingredients: Rice powder, Gelatin, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 250 by MET-Rx Drug Interactions

Want to check YOUR meds against Tribulus 250?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus 259

Individual Drug Interactions

The ingredients in Tribulus 250 interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus 250 interact with drugs. Each result below shows which ingredient is responsible. Tribulus

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 250 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 250, from the product label.

MET-Rx

See all MET-Rx products
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

Tribulus 250 by MET-Rx: Common Questions

Does Tribulus 250 by MET-Rx interact with any medications?
Yes. Based on its ingredients, Tribulus 250 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 250 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No. Tribulus may affect your hormones and safety in pregnancy isn't established, so it's rated possibly unsafe. While breastfeeding, there isn't enough reliable safety information either, so you should skip it. Talk with your doctor if you're planning pregnancy or have questions.
What side effects should I watch for?
Most people experience mild stomach upset—cramping, nausea, vomiting, diarrhea, or constipation—though these occurred at similar rates in studies comparing tribulus to placebo. Rare but serious effects like liver or kidney injury and seizures have been reported. If you notice any unusual symptoms, stop taking it and contact your doctor or pharmacist.
How long does tribulus take to work?
The product facts don't specify a timeframe for sexual function or other uses. Talk with your doctor or pharmacist about realistic expectations for the dose and duration you're considering.
Is this safe long-term?
Tribulus is often well tolerated in the short term, but quality and long-term safety data are limited. If you're thinking about using it for months or longer, check with your doctor or pharmacist first.
Does this product have fillers?
Yes. It contains rice powder, gelatin, vegetable magnesium stearate, and silica as inactive ingredients that help bind and stabilize the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 250 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 250 label
Go deeper

The Full Monographs Behind Tribulus 250’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 250's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team