Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Triple Omega Ingredients & Drug Interactions

by MET-Rx

Triple Omega label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Omega against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Triple Omega is a dietary supplement by MET-Rx with 5 active ingredients. Its ingredients are commonly taken for high triglycerides, heart health, joint pain and inflammation.Based on those ingredients, 520 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fish Oil, organic Flaxseed Oil, Borage seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Triple Omega by MET-Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Omega by MET-Rx — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Triple Omega by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 12 active ingredients.
  • “Omega-3 Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Omega-6 Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Omega-9 Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Triple Omega by MET-Rx is a 12-ingredient blend of fatty acids. The active ingredients are fish oil (rich in omega-3s), organic flaxseed oil and borage seed oil (both sources of plant-based omega-6 and omega-3 compounds), and oleic acid from oleic-acid rich sources.

The product also contains several other omega fatty acid groups and their components — including eicosapentaenoic acid, docosahexaenoic acid, gamma-linolenic acid, alpha-linolenic acid, and linoleic acid — which work together to deliver a broad spectrum of omega-3, -6, and -9 fatty acids. The softgel capsules contain gelatin, glycerin, and mixed tocopherols as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Metabolic health and muscle structural support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Cardiovascular disease (CVD), Coronary heart disease (CHD), Dyslipidemia, Heart failure — and 4 related terms.
  • The strongest evidence on file: Fish Oil is rated "Possibly Effective" for Heart failure (Natural Medicines).
  • Also on file: Fish Oil is rated "Possibly Effective" for HIV/AIDS-related dyslipidemia.
  • Also on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD).

Fish oil in this product is Effective for high triglycerides (fat in your blood), and Possibly Effective for heart failure, cachexia (muscle wasting), and nonalcoholic fatty liver disease. Oleic acid — one of the omega-9s — is Possibly Effective for high cholesterol and coronary heart disease.

Flaxseed oil, however, shows Possibly Ineffective evidence for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol. Borage seed oil rates as Possibly Ineffective for eczema and Insufficient Reliable Evidence To Rate for ADHD, acute respiratory distress syndrome, and alcoholism.

The overall effectiveness of the combination for general wellness or any single condition isn't established in our data.

The evidence, ingredient by ingredient Fish Oil Flaxseed Oil Borage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fish oil is generally well tolerated at typical supplement doses for most adults. Common mild side effects include abdominal pain, bad breath, fishy aftertaste, heartburn, loose stools, and nausea.

Rarely, high doses (3 grams or more daily) may increase bleeding risk or affect immune function; a case of anaphylaxis has been reported in someone with shellfish allergy. Fish oil is often used in pregnancy for omega-3 intake but should only be taken under a doctor's guidance.

It passes into breast milk — discuss appropriate use with your healthcare provider. Flaxseed oil is generally well tolerated but has limited safety data; check with your doctor before use.

A small number of patients report changes in bowel habits, dry mouth, or indigestion at around 5 grams daily; high doses (30 grams daily or more) have caused loose stools and diarrhea. Safety during breastfeeding is limited, so use only with medical advice.

Borage seed oil's safety data is not robust — the main concern is contamination with liver-toxic pyrrolizidine alkaloids (though certified PA-free seed oil is better tolerated). Borage seed oil should be avoided in pregnancy.

Common side effects are mild (belching, bloating, diarrhea, soft stools). Oleic acid from foods is considered safe, but concentrated supplements lack good study in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Fish Oil Flaxseed Oil Borage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Borage, Flaxseed Oil, Fish Oil, Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 521 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Triple Omega, double-check if you take immunosuppressants like tacrolimus, cyclosporine, or sirolimus (Moderate risk of raised drug levels). Also verify antihypertensive drugs (blood pressure medications), anticoagulant or antiplatelet drugs (blood thinners like warfarin), contraceptive pills, antidiabetes drugs, orlistat (Xenical, Alli), ezetimibe (Zetia), phenothiazines (psychiatric medications), or any CYP3A4-inducing drugs.

No interactions are documented for several of the individual omega fatty acids we could not check. If you're unsure about any medication, use the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Triple Omega is best for someone seeking a broad-spectrum omega supplement, but it's not for everyone. If you take any blood pressure medication, blood thinner, contraceptive, diabetes drug, cholesterol drug (especially ezetimibe), psychiatric medication, or any immunosuppressant (especially after transplant), check your specific medications with the search tool first.

Talk to your pharmacist before adding this product — the interactions are real and sometimes require dose adjustments.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Omega, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560101578
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 63674
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Omega by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
786560101578
IngredientAmount% DV
Calories25 Calorie(s)--
Calories from Fat20 Calorie(s)--
Omega-3 Fatty Acids0 NP--
Eicosapentaenoic Acid0 NP--
Docosahexaenoic Acid0 NP--
Protein1 Gram(s)1%
Saturated Fat1 Gram(s)2%
Polyunsaturated Fat1.5 Gram(s)--
Cholesterol10 mg3%
Gamma-Linolenic Acid0 NP--
Omega-6 Fatty Acids0 NP--
Omega-9 Fatty Acids0 NP--
Total Fat2.5 Gram(s)4%
Total Omega-3 Fatty Acids907 mg--
Total Omega-6 Fatty Acids219 mg--
Linoleic Acid0 NP--
Total Omega-9 Fatty Acids179 mg--
Oleic Acid0 NP--
Alpha-Linolenic Acid0 NP--
Fish Oil0 NP--
Typical Fatty Acid Profile0 NP--
Other Fatty Acids0 NP--
Monounsaturated Fat0.5 Gram(s)--
organic Flaxseed Oil0 NP--
Borage seed Oil0 NP--
Triple Omega 3-6-9 Proprietary Blend2400 mg--

Other ingredients: Gelatin, Glycerin, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

FOR BEST RESULTS, TAKE ONE SERVING 1-2 TIMES DAILY WITH A MEAL.

Directions: For adults, take two (2) softgels one to two times daily, preferably with meals.

General Statements

INTENSE TRAINING CAN TAKE A TOLL ON YOUR MUSCLES, WHICH IS WHY ALL ATHLETES SHOULD MAKE SURE THEY ARE GETTING ENOUGH ESSENTIAL FATTY ACIDS.

- MUSCLE CELL SUPPORT - OMEGA 3-6-9 SUPPORTS HEALTHY JOINTS

DAILY NUTRITION

Formula

MET-Rx TRIPLE OMEGA PROVIDES OMEGA-3, OMEGA-6 AND OMEGA-9 FATTY ACIDS NEEDED FOR METABOLIC HEALTH AND STRUCTURAL SUPPORT OF MUSCLE CELLS – WHICH MAY BECOME DAMAGED FROM HARD TRAINING.*

Contains fish (anchovy, mackerel, sardine) ingredients.

Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

WARNING: If you are pregnant, nursing, taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Contains fish (anchovy, mackerel, sardine) ingredients.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

YOU CAN’T FAKE STRONG

2014

General

10157 04E B52362 JAC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Omega by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Omega label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Omega by MET-Rx

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Triple Omega 3-6-9 Proprietary Blend

2400 mg per serving

Other (inactive) ingredients: Gelatin, Glycerin, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Omega by MET-Rx Drug Interactions

Want to check YOUR meds against Triple Omega?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
520Drugs
517 Moderate 3 Minor

Ingredients driving the most interactions

Fish Oil 327
organic Flaxseed Oil 293
Borage seed Oil 226

Individual Drug Interactions

The ingredients in Triple Omega interact with 520 drugs. Click any drug to see the details.

3 of the 5 ingredients in Triple Omega interact with drugs. Each result below shows which ingredient is responsible. Fish Oil organic Flaxseed Oil Borage seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Omega with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fish Oil9 drug types · 327 drugs

Antihypertensive Drugs

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Clinical evidence indicates that fish oils can modestly lower blood pressure and might have additive effects in patients treated with antihypertensives.

Likelihood Probable Evidence B
Contraceptive Drugs

Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.
There is some evidence that contraceptive drugs might interfere with the triglyceride lowering effects of fish oils.

Likelihood Probable Evidence B
Cyclosporine (Neoral, Sandimmune)

Taking fish oil with cyclosporine might increase levels and adverse effects of cyclosporine.
In kidney transplant recipients on a general immunosuppressive regimen, taking omega-3 fatty acids daily seems to increase peak blood levels of cyclosporine when compared with placebo. This increase was as much as 20% after one month. However, the area under the curve was not significantly affected.

Likelihood Probable Evidence B
Orlistat (Xenical, Alli)

Theoretically, taking fish oil with orlistat might decrease the absorption of fish oil fatty acids.
Orlistat binds lipase in the gastrointestinal tract and reduces fat absorption. Theoretically, taking fish oil with orlistat might decrease absorption of fish oil fatty acids. To avoid this potential interaction, recommend separating administration of orlistat and fish oil by at least 2 hours.

Likelihood Probable Evidence D
Sirolimus (Rapamune)

Taking fish oil with sirolimus might increase levels and adverse effects of sirolimus.
Pharmacokinetic research shows that omega-3 fatty acids increase exposure to sirolimus in kidney transplant patients on a calcineurin inhibitor-free immunosuppressive regimen. A 25% dose reduction in sirolimus was required to keep patients within the expected trough-concentration window. Researchers hypothesize that this may be due to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.

Likelihood Probable Evidence B
Tacrolimus (Prograf)

Taking fish oil with tacrolimus might increase levels and adverse effects of tacrolimus.
In a small group of patients, taking fish oil 2.6 grams (Omacor) daily for 4 weeks increased the 8-hour area under the curve of tacrolimus by 25% when compared with baseline. Peak levels were increased by approximately 22%. Researchers hypothesize that this may be due either to an increase in bioavailability or to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, evidence is conflicting.
While fish oil may not be a potent inhibitor of platelet function, high doses of fish oil might have antiplatelet effects. Theoretically, concomitant use of fish oil with anticoagulant or antiplatelet drugs may increase the risk of bleeding. However, the most rigorous research shows that short-term doses of fish oil 10 grams daily or long-term doses of 1.5 grams daily for up to 52 weeks does not increase the risk of bleeding or affect coagulation parameters in chronically ill and vulnerable patients. Other controlled research shows that fish oil does not affect platelet function or increase the risk of bleeding. Some research even suggests that perioperative fish oil use decreases bleeding risk. Some research suggests fish oil does not have additive antiplatelet effects when combined with aspirin, but other clinical evidence suggests that adding fish oil to low-dose aspirin treatment increases antiplatelet effects in patients who are aspirin-resistant. Also, some clinical research seems to show that fish oil has additive antiplatelet effects when used with aspirin and clopidogrel compared to aspirin and clopidogrel alone.

Likelihood Unlikely Evidence B
Platinum Agents

Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.
Platinum-induced fatty acids (PIFAs) are fatty acids secreted from human and mouse stem cells when exposed to platinum-based chemotherapy. Animal research suggests that PIFAs cause resistance to chemotherapy by stimulating lysophospholipid production in the spleen, which interferes with the DNA damage caused by certain chemotherapy drugs. One PIFA, known as 16:4(n-3), has been found in both raw fish and some commercially available fish oil products. Mackerel and herring have high PIFA concentrations, while salmon and tuna have low PIFA concentrations. Levels of PIFA in commercial fish oil products ranged from 0.2- 5.7 microMol. Animal research shows that PIFA-containing fish oil products cause resistance to cisplatin, fluorouracil, irinotecan, and oxaliplatin. It is unclear if all commercially available fish oil products contain PIFAs. Additionally, it is argued that levels of PIFA found in some fish oil products are too low to be of clinical concern. Furthermore, a lack of chemotherapy resistance in countries with high fish intake, such as Greenland, Japan, and Norway, suggest that this interaction may not be clinically significant.

Likelihood Unlikely Evidence D
Warfarin (Coumadin)

Fish oil may have antiplatelet effects and might increase the risk of bleeding if used with warfarin.
Fish oil has antiplatelet effects at high doses. Case reports show elevated INR in patients taking warfarin and fish oil 1-2 grams daily. However, some clinical research shows that taking fish oil 3-6 grams daily does not significantly increase INR in patients taking warfarin.

Likelihood Unlikely Evidence B
Fish Oil full monograph & interactions

organic Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
organic Flaxseed Oil full monograph & interactions

Borage seed Oil3 drug types · 226 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.

Likelihood Possible Evidence D
Borage seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Omega, from the product label.

MET-Rx

See all MET-Rx products
Name
MET-Rx Nutrition, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-556-3879
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

Triple Omega by MET-Rx: Common Questions

Does Triple Omega by MET-Rx interact with any medications?
Yes. Based on its ingredients, Triple Omega has a known interaction with 520 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Omega contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Triple Omega if I'm pregnant?
Fish oil in this product is often used in pregnancy for omega-3 intake but only under your doctor's guidance. Flaxseed oil has limited safety data in pregnancy — check with your doctor. Borage seed oil should be avoided in pregnancy due to concerns about liver-toxic alkaloids. Oleic acid lacks good study in pregnancy. Talk with your doctor or pharmacist for personalized advice before using this product.
Is this safe while breastfeeding?
Fish oil's omega-3s pass into breast milk; discuss appropriate use with your healthcare provider. Flaxseed oil has limited safety information during breastfeeding — use only with medical advice. Borage seed oil is best avoided due to safety concerns. There's not enough data on oleic acid during breastfeeding. Your doctor or pharmacist can help you decide.
What does fish oil do in this product?
Fish oil is Effective for high triglycerides and Possibly Effective for heart failure, muscle wasting, and fatty liver disease. It's your main source of omega-3s in this blend.
Does flaxseed oil actually work for anything?
In our data, flaxseed oil rates as Possibly Ineffective for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol. The evidence doesn't support its use for these conditions.
Will this help my cholesterol?
Oleic acid (an omega-9 in this blend) is Possibly Effective for high cholesterol and heart disease. Fish oil is Effective for high triglycerides. However, flaxseed oil rates as Possibly Ineffective for cholesterol. Your results will depend on your individual situation — ask your doctor or pharmacist.
What are the most common side effects?
Fish oil often causes mild symptoms like bad breath, fishy aftertaste, heartburn, loose stools, and nausea. Flaxseed oil may cause bowel changes, dry mouth, or indigestion at typical doses. Borage seed oil can cause belching, bloating, diarrhea, and soft stools. These are usually mild and occur in a small number of users.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Omega label
Go deeper

The Full Monographs Behind Triple Omega’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fish Oil

Interacts with 327 drugs

Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally...

Read the full Fish Oil monograph → Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph → Herb & supplement monograph

Borage

Interacts with 226 drugs

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...

Read the full Borage monograph →
Sources

Sources & How We Checked

Triple Omega's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 277 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Docosahexaenoic Acid (dha) 49 references
  1. Akedo I, Ishikawa H, Nakamura T, et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules (abstract). Jpn J Clin Oncol PubMed
  2. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  3. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
  4. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  5. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  6. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  7. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  8. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
  9. Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
  10. Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. PubMed
  11. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 2002;76:1007-15.. PubMed
  12. Marangell LB, Martinez JM, Zboyan HA, et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160:996-8.. PubMed
  13. Leng GC, Smith FB, Fowkes FG, et al. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins Leukot Essent Fatty Acids 1994;51:101-8. PubMed
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Omega-6 Fatty Acids 20 references
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See these in context on the Fish Oil monograph →

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  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
  18. Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
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  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

Borage 11 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
  4. Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
  5. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  6. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  7. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  8. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  9. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  10. Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
  11. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Borage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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