Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Triple Test Afritest Ingredients & Drug Interactions

by VPX

Triple Test Afritest label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Test Afritest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Triple Test Afritest is a dietary supplement by VPX with 6 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 514 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Tongkat Ali extract, Velvet Bean, Burdock extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Triple Test Afritest by VPX

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Test Afritest by VPX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Triple Test Afritest by VPX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Botanical Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.
  • “Mineral” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Triple Test Afritest has 6 active ingredients: Boron, Burdock extract, Tongkat Ali extract, Paederia Foetida extract, Velvet Bean (also called Cowhage), and Massularia. Velvet Bean is notable because it contains levodopa, a potent compound that acts like a medication in your body and is used clinically for Parkinson's disease.

The other active ingredients are herbal extracts or minerals intended to support various aspects of wellness. The capsule also contains several inactive ingredients (Safflower Oil, Lecithin, Polyglyceryl-3 Oleate, Glyceryl Monostearate, purified Water, Hypromellose, and Titanium Dioxide) that help bind and deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: optimize testosterone levels and male performance.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 4 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.

The evidence for these ingredients is mixed and often limited. Boron is likely effective for boron deficiency and possibly effective for vaginal yeast infections and radiation skin damage, but possibly ineffective for athletic performance.

Tongkat Ali extract is possibly effective for sexual desire but possibly ineffective for athletic performance; we don't have established evidence for its use in back pain, bone health, or blood sugar control. For the other ingredients—Burdock, Paederia Foetida, Velvet Bean, and Massularia—the evidence we hold either rates as insufficient to draw conclusions (acne, eczema, various conditions for Burdock and Velvet Bean) or we have no effectiveness data on file.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports that use for you.

The evidence, ingredient by ingredient Burdock Eurycoma Longifolia Cowhage Boron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron is generally well tolerated when doses stay below the upper safe limit of 20 mg daily, but high doses can be toxic. Common mild effects at normal doses include loss of appetite, skin rash, and indigestion.

Burdock is well tolerated as a food and for short-term use; serious allergic reactions including anaphylaxis are rare but possible. Tongkat Ali is generally tolerated in short-term studies, though long-term safety isn't well established, and it can raise testosterone levels, which brings a risk of acne, insulin resistance, and liver effects if levels climb too high.

Velvet Bean causes diarrhea, gas, and mucosal irritation in some people, and about 3% of trial participants reported insomnia. Paederia Foetida and Massularia safety data are not on file.

Regarding pregnancy: boron is rated as possibly unsafe and should be avoided during pregnancy and breastfeeding. Burdock, Tongkat Ali, and Velvet Bean should be avoided during both pregnancy and breastfeeding due to insufficient safety data and possible hormonal or other effects.

Boron is also rated possibly unsafe during lactation specifically.

Side effects, ingredient by ingredient Burdock Eurycoma Longifolia Cowhage Boron

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Burdock, Cowhage, Eurycoma Longifolia.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 514 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop and check with your doctor or pharmacist before using Triple Test Afritest if you take methyldopa, MAO inhibitors, levodopa, blood thinners (anticoagulants or antiplatelet agents), blood sugar medications, antipsychotic drugs, older antidepressants (tricyclic antidepressants), propranolol, guanethidine, or are scheduled for surgery with certain anesthesia agents. The Velvet Bean ingredient contains levodopa, which carries Major-severity risks with blood pressure and Parkinson's medications, and Moderate risks with several other drug classes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Triple Test Afritest is a multi-ingredient supplement containing the drug-like compound levodopa (via Velvet Bean) and several herbal extracts. It's not appropriate if you take blood pressure medications, blood thinners, antidiabetic drugs, antipsychotics, or certain antidepressants without careful review.

The product is not recommended during pregnancy or breastfeeding. Before starting it, check your exact medications against the tool on this page, and go over the results with your own doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Test Afritest, straight from the product label.

Brand VPX
Barcode (UPC) 610764381002
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42148
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Test Afritest by VPX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
610764381002
IngredientAmount% DV
Calories9 {Calories}--
Calories from Fat9 {Calories}--
Total Fat1 Gram(s)2%
Boron212 mcg--
Burdock extract0 NP--
Tongkat Ali extract0 NP--
Botanical Blend1200 mg--
Peaderia Foetida extract0 NP--
Velvet Bean0 NP--
Massularia0 NP--
Mineral0 NP--

Other ingredients: Safflower Oil, Lecithin, Polyglyceryl-3 Oleate, Glyceryl Monostearate, purified Water, Hypromellose, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN.

ALLERGEN WARNING: Manufactured in a facility that processes milk, soy, tree nuts and peanuts. ALLERGEN INFORMATION: Contains soy (as soy lecithin).

DO NOT PURCHASE IF SAFETY SEAL IS BROKEN OR MISSING.

Brand IP Statement(s)

TRIPLE TEST(TM) stands alone as a total support system for optimizing testosterone levels.

LIVE POWERFULLY(TM)

(C) 2014

General Statements

Testosterone has many important functions in the body such as helping to build muscle, burn fat, and increase strength & performance. It's also necessary to promote energy levels and sex drive. However, as men age, testosterone levels decline. Even less obvious factors than age, such as environmental estrogens and pollutants, can lower testosterone levels. The result is a less muscular, out of shape, less energetic version of yourself. Fighting this decline in testosterone is necessary; not only to maintain youthful levels of lean body mass and low levels of body fat, but also to maintain strength, energy, and of course, sex drive. Testosterone works synergistically with all of the anabolic hormones of the body, such as Insulin-like growth factor and growth hormone.

30 DAY CYCLE

ALL RIGHTS RESERVED.

TESTOSTERONE SUPPORT MATRIX

Formulation

Contains no banned substances. Clean Athlete approved.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

V002

Seals/Symbols

VPX(R)

100% NATURAL

VITAL PHARMACEUTICALS GMP

{American flag} Made in USA from Domestic & Imported Ingredients in VPX State of the Art GMP Facilities

GLUTEN FREE GF

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Contains soy (as soy lecithin).

Storage

PROTECT FROM HEAT, LIGHT AND MOISTURE.

STORE AT 15-30(0)C (59-86(0)F)

Suggested/Recommended/Usage/Directions

RECOMMENDED USE: As a dietary supplement, take three capsules daily, preferably with meals. Unlike most other testosterone formulas, TRIPLE TEST(TM) does not need to be cycled. This is important in maintaining more consistent testosterone levels compared to products that are cycled, which greatly disrupts natural hormone balance.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Test Afritest by VPX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Test Afritest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Test Afritest by VPX

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Botanical Blend

1200 mg per serving

Mineral

0 NP per serving

Other (inactive) ingredients: Safflower Oil, Lecithin, Polyglyceryl-3 Oleate, Glyceryl Monostearate, Purified Water, Hypromellose, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Test Afritest by VPX Drug Interactions

Want to check YOUR meds against Triple Test Afritest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
514Drugs
17 Major 301 Moderate 196 Minor

Ingredients driving the most interactions

Tongkat Ali extract 249
Velvet Bean 193
Burdock extract 122

Individual Drug Interactions

The ingredients in Triple Test Afritest interact with 514 drugs. Click any drug to see the details.

3 of the 6 ingredients in Triple Test Afritest interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali extract Velvet Bean Burdock extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Test Afritest with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali extract5 drug types · 249 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali extract full monograph & interactions

Velvet Bean8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Velvet Bean full monograph & interactions

Burdock extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Test Afritest, from the product label.

VPX

See all VPX products
Web Address
VPXSPORTS.COM
Pharmacist Counseling Corner

Triple Test Afritest by VPX: Common Questions

Does Triple Test Afritest by VPX interact with any medications?
Yes. Based on its ingredients, Triple Test Afritest has a known interaction with 514 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Test Afritest contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Triple Test Afritest contain levodopa?
Yes, through its Velvet Bean ingredient. Levodopa is an active compound used medically for Parkinson's disease, and some Velvet Bean products contain 75–400 mg per dose. This is why it's crucial to check with your doctor if you take any Parkinson's or blood pressure medications.
Can I take this if I'm pregnant or breastfeeding?
No. Boron is rated possibly unsafe in both pregnancy and breastfeeding. Burdock, Tongkat Ali, and Velvet Bean all lack sufficient safety data and are best avoided during pregnancy and while nursing. Talk with your own doctor or pharmacist about what's appropriate for your situation.
What are the most common side effects?
Velvet Bean most often causes diarrhea, gas, and stomach irritation; about 3% of study participants reported insomnia. Boron at normal doses may cause loss of appetite, skin irritation, or indigestion. Burdock is generally well tolerated, though allergic skin reactions have been reported, especially with prolonged use.
Is this product proven to work?
Only Boron for boron deficiency is rated likely effective. Tongkat Ali for sexual desire and Boron for yeast infections and radiation skin damage are possibly effective. For most of the other claims—back pain, bone health, athletic performance, and conditions addressed by Burdock, Paederia Foetida, and Massularia—we don't have established evidence.
Why does this product have so many drug interactions?
The Velvet Bean ingredient contains levodopa, which interacts with many medications because it affects dopamine, blood pressure, and how the liver processes other drugs. Additionally, Tongkat Ali and Burdock each have their own documented interactions. Together, these create a broad range of potential interactions with 513 individual medications.
What if I take propranolol?
A study showed that Tongkat Ali in this product can reduce propranolol levels by about 29%, which may weaken its effect on your heart rate or blood pressure. Check with your own doctor or pharmacist before adding this supplement if you're on propranolol or any other medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Triple Test Afritest is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Test Afritest label
Go deeper

The Full Monographs Behind Triple Test Afritest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 249 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph →
Sources

Sources & How We Checked

Triple Test Afritest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
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See these in context on the Cowhage monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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