Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Reishi Ingredients & Drug Interactions

by Sun Potion

Reishi label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Reishi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Reishi is a dietary supplement by Sun Potion with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ganoderma lucidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Reishi by Sun Potion

Ask about any prescription or over-the-counter medication and we check it for interactions with Reishi by Sun Potion — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Reishi by Sun Potion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Ganoderma lucidum, the reishi mushroom. That's it — no fillers or other ingredients listed.

Reishi is used traditionally as an adaptogen, a substance thought to help the body handle stress, though the evidence for many of its claimed effects is still being studied.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune function, mental clarity, stress relief and longevity.
  • We looked for evidence on: Stress, Psychological well-being, Insomnia, Chronic fatigue syndrome (CFS), Aging, Cardiovascular disease (CVD) — and 4 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Chronic fatigue syndrome (CFS), Hypertension, Insomnia, and more.

The evidence for reishi is patchy. For high cholesterol (hyperlipidemia), it appears possibly ineffective based on available data.

For altitude sickness, Alzheimer's disease, and athletic performance, we don't yet have reliable evidence to rate whether it works. The data we hold doesn't show strong proof for most uses people ask about.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi is generally well tolerated in the short term, with most people experiencing no problems. The most common side effects are mild — dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Some people report sore throat or runny nose, and respiratory allergy to reishi spores can occur; rare symptoms include insomnia and headache. Long-term safety hasn't been well studied, so we can't say how it behaves over months or years.

There isn't enough safety data to recommend it during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice if either applies to you.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this reishi powder, double-check if you use blood thinners or antiplatelet drugs — higher doses may increase bleeding risk. Also check blood pressure medications, since reishi can lower blood pressure, and diabetes medications, where the interaction is theoretical but possible.

Use the medication checker on this page with your exact drug names and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Reishi may appeal to you if you're exploring traditional adaptogens, but the evidence for most claims is weak or absent. If you take blood thinners, blood pressure medications, or diabetes drugs, check your exact medications with the tool below before starting.

Long-term safety is unknown, and pregnancy or breastfeeding requires a conversation with your pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Reishi, straight from the product label.

Brand Sun Potion
Barcode (UPC) 045635342521
Net contents 3.5 Ounce(s); 100 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 338025
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Reishi by Sun Potion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
100
UPC/BARCODE
045635342521
IngredientAmount% DV
Ganoderma lucidum1 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Organic Reishi Mushroom Powder Mushroom of Immortality This is a revered and sacred food, traditionally used in Eastern Medicine to "Nourish the heart and pacify the spirit"

Full Spectrum Mushroom Powder

Organic Reishi Mushroom These are powerful foods.

100% Organic full life cycle blend of Black, Red, Purple, & White Reishi fruit body, primordia, spores and extracellular compounds.

Formulation

Today, use of Reishi may support: Immune function Mental clarity Stress relief Longevity Protection & healing

Transformational foods Queen healer mushroom

Organic

Our source Product of USA

Certified Organic by CCOF USDA Organic CCOF Certified Organic

Suggested/Recommended/Usage/Directions

Invitations for use Add 1/2 teaspoon in warm water or tea. Excellent addition to broths, miso soup, coffee elixirs, smoothies, raw desserts, busy schedules

Consume in small, regular doses over a lifetime. In Joy!

General Statements

Contains 100 servings

Thank you for being here This is an amazing time on the planet. Participate in the shift. Experience transformational foods with sun potion! We want you to feel amazing. For daily alchemy + recipes Find us @sunpotion #sunpotion We invite you to reuse the glass jar. Thank you.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Precautions

Keep out of reach of children.

Consult your healthcare practitioner before use if pregnant.

Seals/Symbols

USDA Organic CCOF Certified Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Reishi by Sun Potion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Reishi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Reishi by Sun Potion

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

Ganoderma lucidum

Interacts with
375 drugs
1 Gram(s) per serving Form: Ganoderma lucidum, Ganoderma lucidum, Ganoderma lucidum, Ganoderma lucidum

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Ganoderma lucidum monograph & interactions
Interaction report

Reishi by Sun Potion Drug Interactions

Want to check YOUR meds against Reishi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Ganoderma lucidum 375

Individual Drug Interactions

The ingredients in Reishi interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Reishi interact with drugs. Each result below shows which ingredient is responsible. Ganoderma lucidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Reishi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ganoderma lucidum3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Ganoderma lucidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Reishi, from the product label.

Sun Potion

See all Sun Potion products
Name
Sun Potion, LLC Transformational Foods
Street Address
430 E. Gutierrez St.
City
Santa Barbara
State
CA
ZipCode
93101
Phone Number
1-866-676-8466
Web Address
www.SunPotion.com
Pharmacist Counseling Corner

Reishi by Sun Potion: Common Questions

Does Reishi by Sun Potion interact with any medications?
Yes. Based on its ingredients, Reishi has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Reishi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take reishi if I'm pregnant?
There isn't enough safety data to know whether reishi is okay during pregnancy, so the data advises against it. Talk with your doctor or pharmacist for personalized advice — they know your situation and can help you decide.
Can I take reishi while breastfeeding?
The safety data doesn't support breastfeeding use because there isn't enough information. Check with your pharmacist or doctor before starting — they can give you advice tailored to your needs.
What are the most common side effects?
Most people tolerate reishi well. The most frequent side effects are mild: dizziness, dry mouth, itching, nausea, rash, and stomach upset. A few people report sore throat, runny nose, insomnia, or headache, but these are less common.
Does reishi actually work for anything?
The evidence is mixed. For high cholesterol, it appears possibly ineffective. For altitude sickness, Alzheimer's disease, and athletic performance, we simply don't have reliable evidence to say whether it works. Talk with your pharmacist about what you're hoping to treat — they can help you understand what the data actually shows.
Is it safe to take reishi long-term?
Reishi is generally well tolerated in the short term, but long-term safety hasn't been well studied. We don't know yet how safe it is over months or years, so check with your pharmacist if you're thinking about using it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Reishi label
Go deeper

The Full Monographs Behind Reishi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Reishi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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