Amoxicillin

68 interactions 441 cited references
Also sold as: Amoxi Drop Amoxi-tabs Amoxil® Amoxil® Pediatric Drops Biomox Dispermox® Larotid® Suspension Moxatag Moxtag® Polymox® Suspension Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) Trimox Trimox® Trimox® Pediatric Drops Wymox®
About Amoxicillin

Amoxicillin is a penicillin-like antibiotic used to treat bacterial infections like pneumonia, bronchitis, and ear, nose, throat, urinary tract, and skin infections. Read the full Amoxicillin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acenocoumarol Chlortetracycline Cholera Vaccine, Live Coumarin Demeclocycline Minocycline Topical
48 Major 5 Moderate 15 Minor
All (68) Major (48) Moderate (5) Minor (15)

Major

Amoxicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Amoxicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Amoxicillin Estradiol Topical Divigel Reduced efficacy of oral contraceptive Details Amoxicillin Estradiol Transdermal Patch Alora® Reduced efficacy of oral contraceptive Details Amoxicillin Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Amoxicillin Levonorgestrel Intrauterine System Kyleena Reduced efficacy of oral contraceptive Details Amoxicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Amoxicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Moderate

Amoxicillin Khat Reduced effectiveness of amoxicillin Details Amoxicillin Lixisenatide Delayed therapeutic effect Details Amoxicillin Piperine Increased bioavailability of amoxicillin Details Amoxicillin Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Amoxicillin Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Minor

Amoxicillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Amoxicillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Amoxicillin Amikacin Loss of aminoglycoside efficacy Details Amoxicillin Dibekacin Loss of aminoglycoside efficacy Details Amoxicillin Framycetin Loss of aminoglycoside efficacy Details Amoxicillin Gentamicin Loss of aminoglycoside efficacy Details Amoxicillin Isepamicin Loss of aminoglycoside efficacy Details Amoxicillin Kanamycin Loss of aminoglycoside efficacy Details Amoxicillin Neomycin Loss of aminoglycoside efficacy Details Amoxicillin Netilmicin Loss of aminoglycoside efficacy Details Amoxicillin Streptomycin Loss of aminoglycoside efficacy Details Amoxicillin Tobramycin Bethkis Loss of aminoglycoside efficacy Details Amoxicillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Amoxicillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Amoxicillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.