Clonazepam
31 interactions 2 explained in plain English
Also sold as:
Klonopin
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Hydromorphone Rectal
Fentanyl Transdermal Patch
Diphenhydramine Injection
Orlistat
Morphine Injection
Major
Clonazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Clonazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Clonazepam Aripiprazole Injection Abilify Increased risk of CNS depression Details Clonazepam Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Clonazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Clonazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Clonazepam Calcifediol Rayaldee Altered serum levels of calcifediol Details Clonazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Clonazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Clonazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Clonazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Clonazepam Diphenhydramine Injection Banophen Increased risk of CNS depression Details Clonazepam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Clonazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Clonazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clonazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Clonazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Clonazepam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Clonazepam Ketoconazole Topical Extina® Foam Increased clonazepam exposure Details Clonazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Clonazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Clonazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Clonazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Clonazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clonazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clonazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clonazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Clonazepam Nevirapine Viramune Reduced clonazePAM exposure and reduced nevirapine exposure Details Clonazepam Orlistat Alli Reduced efficacy of anticonvulsant DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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