Isradipine

113 interactions 461 cited references

Also sold as: DynaCirc® DynaCirc® CR

About Isradipine

Isradipine is used to treat high blood pressure. Isradipine is in a class of medications called calcium channel blockers. It works by relaxing the blood vessels so your heart does not have to pump as hard. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessel… Read the full Isradipine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefloquine Gemifloxacin Dolasetron Injection Arsenic Trioxide Injection Disopyramide Clonidine Transdermal Patch

1 Contraindicated 96 Major 16 Moderate

All (113) Contraindicated (1) Major (96) Moderate (16)

Contraindicated

Isradipine Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Major

Isradipine Amitriptyline Elavil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Isradipine Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Isradipine Digoxin Cardoxin® An increased risk of bradycardia and an increased risk of complete heart block Details Isradipine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Epirubicin Ellence Increased risk of heart failure Details Isradipine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Acetophenazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Ajmaline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Amoxapine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Aprindine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Astemizole An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Azimilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Carbamazepine Carbatrol Reduced dihydropyridine calcium channel blockers and reduced efficacy of dihydropyridine calcium channel blockers Details Isradipine Ceritinib Zykadia Increased CYP3A substrate exposure Details Isradipine Chloral Hydrate An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Chlorpromazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Isradipine Dantrolene Dantrium Severe hyperkalemia with cardiovascular collapse Details Isradipine Darunavir Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Isradipine Desipramine Norpramin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Dibenzepin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Dronedarone Multaq An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Droperidol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Encainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Enflurane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Isradipine Erythromycin Erythrocin Stearate An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.