Rifabutin

65 interactions 4 explained in plain English
Also sold as: Mycobutin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Rifabutin Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Rifabutin Abametapir Explained Increased exposure of CYP3A4 substrate Details Rifabutin Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Rifabutin Atogepant Qulipta Reduced atogepant exposure Details Rifabutin Atovaquone Mepron Reduced atovaquone exposure Details Rifabutin Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Rifabutin Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Rifabutin Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Rifabutin Amlodipine Amvaz® Reduced amLODIPine exposure Details Rifabutin Bedaquiline Sirturo Increased bedaquiline metabolite M2 and M3 exposure, reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Rifabutin Brigatinib Alunbrig Decreased brigatinib exposure and efficacy Details Rifabutin Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifabutin Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifabutin Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Rifabutin Cyclosporine Injection Atopica Reduced cycloSPORINE exposure and reduced efficacy of cycloSPORINE Details Rifabutin Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure and reduced efficacy of cycloSPORINE Details Rifabutin Dabigatran Pradaxa® Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Rifabutin Dabigatran Etexilate Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Rifabutin Dapsone Aczone Reduced dapsone exposure Details Rifabutin Dapsone Topical Aczone Reduced dapsone exposure Details Rifabutin Digoxin Cardoxin® Reduced digoxin exposure Details Rifabutin Doravirine Pifeltro Reduced doravirine exposure, reduced efficacy and an increased risk of doravirine resistance Details Rifabutin Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Rifabutin Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Rifabutin Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Rifabutin Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Rifabutin Erdafitinib Balversa Reduced erdafitinib exposure Details Rifabutin Erlotinib Tarceva Decreased erlotinib exposure and potential loss of efficacy Details Rifabutin Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifabutin Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifabutin Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Rifabutin Exemestane Aromasin Reduced exemestane exposure Details Rifabutin Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Rifabutin Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Rifabutin Glasdegib Daurismo Reduced glasdegib exposure Details Rifabutin Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Rifabutin Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Rifabutin Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.