Rimegepant

15 interactions 1 explained in plain English
Also sold as: Nurtec Nurtec® ODT
About Rimegepant

Rimegepant is a calcitonin gene-related peptide receptor antagonist used to prevent and treat migraine headaches. Read the full Rimegepant drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Cyclosporine Injection Cyclosporine Ophthalmic Finerenone Ketoconazole Topical Lenacapavir Injection
12 Major 3 Moderate
All (15) Major (12) Moderate (3)

Major

Rimegepant Abametapir Explained Increased exposure of CYP3A4 substrate Details Rimegepant Cyclosporine Injection Atopica Increased exposure of rimegepant Details Rimegepant Cyclosporine Ophthalmic Cequa Increased exposure of rimegepant Details Rimegepant Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Rimegepant Ketoconazole Topical Extina® Foam Increased exposure of rimegepant Details Rimegepant Lenacapavir Injection Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Rimegepant Lenacapavir Oral Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Rimegepant Letermovir Injection Prevymis Increased exposure of rimegepant Details Rimegepant Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Rimegepant Methylergonovine Methergine Increased methylergonovine exposure Details Rimegepant Nafcillin Injection Unipen® Injection Decreased exposure of rimegepant Details Rimegepant Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Rimegepant Dofetilide Tikosyn Increased dofetilide exposure Details Rimegepant Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Rimegepant Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.