Drug & supplement interaction

Agaricus Mushroom + Cladribine

Cladribine brand names: Leustatin, Mavenclad.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Agaricus Mushroom and Cladribine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Agaricus Mushroom and Cladribine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cladribine and Agaricus Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Agaricus Mushroom safety at a glance

Agaricus Mushroom overall Use caution Generally tolerated as a food, but supplement safety and long-term effects are not well established.
Pregnancy Avoid Not enough safety data, so it is best to avoid supplement doses during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid supplement doses while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cladribine and Agaricus Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cladribine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cladribine is filed under 2 classifications — immunosuppressants, oral drugs. Agaricus Mushroom has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Cladribine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Agaricus Mushroom Does Interact With Other Medications

Agaricus Mushroom has 86 moderate known drug interactions in our database — Cladribine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Cladribine)
Taking anything else?

Check Another of Your Medications Against Agaricus Mushroom

Covers the 2,830 medications we’ve checked against Agaricus Mushroom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Agaricus Mushroom and Cladribine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Agaricus Mushroom

    “An allergic reaction has been reported in a female who took a specific agaricus powder product (Sen-Sei-Ro Powder Gold, Kyowa Wellness Co., Ltd.) 1.8 grams daily by mouth for 2 months. The patient developed an urticarial papular rash which resolved when the product was discontinued. Allergic contact cheilitis was also reported in a patient taking a homemade agaricus mushroom extract orally.”

    Agaricus Mushroom · Natural Medicines adverse-effect record, reported in cheilitis.

    2 sources cited
    1. 17185. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
    2. 94720. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.

    Cladribine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cladribine. Read the label on DailyMed ›

  • Stomach upset / Diarrhea / Nausea reported in 4.4% of FDA reports for Cladribine Additional detail

    Agaricus Mushroom

    “In one clinical trial, mild gastrointestinal side effects such as nausea, diarrhea, and abdominal discomfort were reported in 6 of 78 patients taking a specific agaricus powder product (Sen-Sei-Ro Powder Gold, Kyowa Wellness Co., Ltd.) 1.8-5.4 grams orally daily for 60 days.”

    Agaricus Mushroom · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 17185. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.

    Cladribine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cladribine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Agaricus Mushroom

    Recorded for Agaricus Mushroom in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Cladribine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cladribine. Read the label on DailyMed ›

Reported for Agaricus Mushroom but not commonly for Cladribine: liver problems.

Effects for Cladribine come from the ADVERSE REACTIONS section of its FDA label; effects for Agaricus Mushroom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 9,555 voluntary FDA FAERS reports for Cladribine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Cladribine Is Prescribed For, and What Agaricus Mushroom Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Cladribine is a prescription medicine with approved uses on its FDA label. Agaricus Mushroom is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Cladribine is prescribed for: Cladribine tablets (brand name Mavenclad) are used to treat relapsing forms of multiple sclerosis (MS) in adults — specifically relapsing-remitting MS and active secondary progressive MS. Because of its significant safety profile, it is generally reserved for patients who haven't responded well to, or can't tolerate, other MS medicines. It is not recommended for clinically isolated syndrome (CIS), a first episode that may or may not lead to MS. Cladribine injection (given intravenously) is a separate product used to treat active hairy cell leukemia — a rare blood cancer — in patients who have clinically significant anemia, low white blood cell counts, low platelets, or disease-related symptoms.

Agaricus Mushroom has been studied for:

  • Cancer studied, not established Agaricus Mushroom has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Agaricus Mushroom for cancer

    Although there is interest in using oral agaricus mushroom for the treatment of various types of cancer, there is insufficient reliable information about the clinical effects of agaricus mushroom for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cladribine on your own; if you are taking Agaricus Mushroom for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Cladribine

This page covers Agaricus Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cladribine page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Cladribine page

“Cladribine (Leustatin, Mavenclad) treats hairy cell leukemia and relapsing multiple sclerosis by deliberately knocking down part of the immune system, so this list calls for real vigilance. Of the 70 supplements and herbs on file, 53 are immune stimulators, herbs like astragalus, ashwagandha, and ginseng that could push immunity back u…”

Reviewed by 2 · Jul 18, 2026

Open the Cladribine interaction page

One more smart check

Taking Agaricus Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 671 real supplement products containing Agaricus Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agaricus Mushroom. Even though Agaricus Mushroom itself has no known interaction with Cladribine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Agaricus Mushroom and Cladribine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Agaricus Mushroom
Top half

#379 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cladribine
Steady interest

#2,285 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Agaricus Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Agaricus Mushroom and Cladribine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Agaricus Mushroom

What is Agaricus Mushroom?

  • Immune support
  • General wellness and antioxidant
  • Adjunct interest during cancer care
  • Blood sugar support
  • Cholesterol and heart health

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not strong enough to recommend it for treating any disease. If you want to try it, talk with your pharmacist or doctor first, especially if you have a health condition or take other medicines.

Agaricus subrufescens · Agaricaceae · Fruiting body (mushroom), sometimes mycelium · Capsules, tablets, powders, dried mushroom, liquid extracts, teas

An interaction check asks whether these two react with each other — it does not ask whether Agaricus Mushroom is a good idea for someone in your situation. Here is what our Agaricus Mushroom record says about it on its own.

Agaricus Mushroom: dosing

There is no established standard dose for Agaricus mushroom supplements. Studies have used different products and amounts, so it is hard to recommend one specific dose.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. Choosing products from reputable companies that test for purity is wise, since supplements are not tightly regulated.

From our Agaricus Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Agaricus Mushroom monograph & all interactions
Medication

About Cladribine

What Is Cladribine Used For?

Brand names: Leustatin, Mavenclad

Cladribine tablets (brand name Mavenclad) are used to treat relapsing forms of multiple sclerosis (MS) in adults — specifically relapsing-remitting MS and active secondary progressive MS. Because of its significant safety profile, it is generally reserved for patients who haven't responded well to, or can't tolerate, other MS medicines. It is not recommended for clinically isolated syndrome (CIS), a first episode that may or may not lead to MS.

Cladribine injection (given intravenously) is a separate product used to treat active hairy cell leukemia — a rare blood cancer — in patients who have clinically significant anemia, low white blood cell counts, low platelets, or disease-related symptoms.

Most-Reported Side Effects for Cladribine

From FAERS, the FDA’s public side-effect reporting system (9,555 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 814 reports
Headache 681 reports
Lymphocyte count decreased 488 reports
Multiple sclerosis relapse 474 reports
Nausea 423 reports
See full Cladribine drug information
Keep checking

Other Drugs & Agaricus Mushroom

Browse every other medication we’ve checked against Agaricus Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Agaricus Mushroom page.

No interaction 2,743 drugs checked — show the list

We also checked Agaricus Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Agaricus Mushroom list.

See the full Agaricus Mushroom interactions page
See every supplement checked against Cladribine, ranked by severity
Evidence & sources

Agaricus Mushroom References

The 5 references that drive our Agaricus Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Agaricus Mushroom and Cladribine Together: Common Questions

Is it safe to take Agaricus Mushroom with Cladribine?
We do not list a known interaction between Agaricus Mushroom and Cladribine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Agaricus Mushroom and Cladribine have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Agaricus Mushroom and Cladribine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Agaricus Mushroom in each. That is a conversation for your prescriber, especially if Cladribine is being adjusted to a target.
How was the Agaricus Mushroom and Cladribine combination checked?
Interactions in our licensed database are recorded against drug classes. Cladribine is filed under 2 classifications, and Agaricus Mushroom has documented interactions with 1 drug class — none of Cladribine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Agaricus Mushroom interact with any other medications?
Yes. Agaricus Mushroom has 86 documented drug interactions in our database — Cladribine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cladribine interact with any supplements?
Yes. Cladribine has documented interactions with 70 supplements in our database — Agaricus Mushroom is not one of them. The Cladribine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Agaricus Mushroom monograph Uses, safety profile, and every drug interaction in one place Cladribine drug information The full plain-English guide to this medication Cladribine supplement interactions Every supplement checked against Cladribine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cladribine and Agaricus Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.