Drug & supplement interaction

Andiroba + Pemetrexed

Pemetrexed brand names: Alimta, Pemfexy.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Andiroba and Pemetrexed in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andiroba and Pemetrexed

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pemetrexed and Andiroba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andiroba safety at a glance

Andiroba overall Use caution Generally used on the skin; safety of taking it internally is not well studied.
Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pemetrexed and Andiroba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pemetrexed

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pemetrexed is filed under a single classification — organic anion transporter 3 (oat3) substrates. Andiroba has documented interactions with 1 drug class — the most serious being anticonvulsants (minor) — and none of Pemetrexed’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andiroba Does Interact With Other Medications

Andiroba has 50 minor known drug interactions in our database — Pemetrexed isn’t one of them. If you take anything else, check it against the full list below.

Minor 50 No known interaction 2,780 (incl. Pemetrexed)
Taking anything else?

Check Another of Your Medications Against Andiroba

Covers the 2,830 medications we’ve checked against Andiroba. Pick one to open its full report.

What to actually watch for

What Pemetrexed’s Own FDA Label Lists

This is not an interaction — none of it involves Andiroba. These are the most notable effects listed in the ADVERSE REACTIONS section of Pemetrexed’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Low potassium Worth acting on
  • High blood sugar Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pemetrexed. Read the label on DailyMed › Andiroba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Andiroba side to compare — that is a limit of the record, not a statement that Andiroba has no side effects.

Everything else you take

See Every Supplement That Interacts With Pemetrexed

This page covers Andiroba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pemetrexed page lists 4 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: African Wild Potato (moderate), Banderol (moderate), Caffeic Acid (moderate) and Quercetin (moderate).

By severity: 4 moderate.

From our pharmacist’s overview on the Pemetrexed page

“Every supplement on file for pemetrexed (Alimta, Pemfexy) works the same way. Each can slow how the kidneys pull the drug out of the blood, which would let it linger and build to higher levels than intended.”

Reviewed by 2 · Jul 18, 2026

Open the Pemetrexed interaction page

How much people look this up

Where Andiroba and Pemetrexed Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andiroba
Steady interest

#798 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pemetrexed
Top half

#1,332 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andiroba is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andiroba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Andiroba and Pemetrexed records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andiroba

What is Andiroba?

Andiroba
  • Skin care and wound healing
  • Insect repellent
  • Muscle and joint aches
  • Anti-inflammatory skin conditions
  • Hair and scalp care

Andiroba is an oil pressed from the seeds of an Amazonian tree, used mainly on the skin for inflammation, minor wounds, aches, and as an insect repellent. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. It is most often used topically; avoid internal use and use during pregnancy or breastfeeding because safety has not been established.

Carapa guianensis · Meliaceae · Seed oil (mainly), bark, and leaves · Topical oil, skin and hair products, soaps, balms, candles (insect repellent)

An interaction check asks whether these two react with each other — it does not ask whether Andiroba is a good idea for someone in your situation. Here is what our Andiroba record says about it on its own.

Andiroba: dosing

There is no established standard dose for andiroba. Doses have not been confirmed in reliable human studies.For topical products, follow the directions on the label.

From our Andiroba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andiroba monograph & all interactions
Medication

About Pemetrexed Injection

What Is Pemetrexed Injection Used For?

Brand names: Alimta, Pemfexy

Pemetrexed Injection is used for non-squamous non-small cell lung cancer (NSCLC) in several situations: as an initial treatment (combined with pembrolizumab and platinum chemotherapy, or with cisplatin alone), as a maintenance treatment after platinum-based chemotherapy, or as a single agent when the cancer has come back after prior chemotherapy. It is not used for squamous cell non-small cell lung cancer.

Pemetrexed Injection is also used, in combination with cisplatin, for the initial treatment of malignant pleural mesothelioma — a cancer of the lining of the lungs — in patients whose disease cannot be surgically removed or who are not good candidates for surgery.

Most-Reported Side Effects for Pemetrexed

From FAERS, the FDA’s public side-effect reporting system (37,889 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 3,095 reports
Anemia 2,134 reports
Nausea 1,906 reports
Diarrhea 1,824 reports
Pancytopenia 1,773 reports
See full Pemetrexed Injection drug information
Keep checking

Other Drugs & Andiroba

Browse every other medication we’ve checked against Andiroba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
50Minor
2,779No known interaction
50 Minor 2,779 No interaction
Minor

50 interactions

No interaction 2,779 drugs checked — show the list

We also checked Andiroba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,779 medications checked with no known interaction — see the full Andiroba list.

See the full Andiroba interactions page
See every supplement checked against Pemetrexed, ranked by severity
Evidence & sources

Andiroba References

The 3 sources that drive our Andiroba monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andiroba is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Carapa guianensis (Andiroba) — U.S. National Library of Medicine (PubChem / NCBI) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Safely — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andiroba and Pemetrexed Together: Common Questions

Is it safe to take Andiroba with Pemetrexed?
We do not list a known interaction between Andiroba and Pemetrexed. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Andiroba and Pemetrexed combination checked?
Interactions in our licensed database are recorded against drug classes. Pemetrexed is filed under 1 classification, and Andiroba has documented interactions with 1 drug class — none of Pemetrexed's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Andiroba interact with any other medications?
Yes. Andiroba has 50 documented drug interactions in our database — Pemetrexed is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pemetrexed interact with any supplements?
Yes. Pemetrexed has documented interactions with 4 supplements in our database — Andiroba is not one of them. The Pemetrexed interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andiroba monograph Uses, safety profile, and every drug interaction in one place Pemetrexed Injection drug information The full plain-English guide to this medication Pemetrexed supplement interactions Every supplement checked against Pemetrexed, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pemetrexed and Andiroba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.