Drug & supplement interaction

Basil + Crizotinib

Crizotinib brand name: Xalkori.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Basil and Crizotinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Basil and Crizotinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crizotinib and Basil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Basil safety at a glance

Basil overall Generally safe Basil is generally safe when eaten as a food, but concentrated extracts and essential oils are less studied.
Pregnancy Likely Safe When the above ground parts are used in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When the above ground parts are used in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crizotinib and Basil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Crizotinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Crizotinib is filed under 5 classifications — including qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors, p-glycoprotein substrates. Basil has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Crizotinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Basil Does Interact With Other Medications

Basil has 289 moderate known drug interactions in our database — Crizotinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Crizotinib)
Taking anything else?

Check Another of Your Medications Against Basil

Covers the 2,830 medications we’ve checked against Basil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Basil and Crizotinib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Basil

    “Allergic contact dermatitis has been reported in a 45-year old woman with occupational exposure to basil.”

    Basil · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 95140. Kiec-Swierczynska M, Krecisz B, Chomiczewska D, et al. Occupational allergic contact dermatitis caused by basil (Ocimum basilicum). Contact Dermatitis 2010;63(6):365-7.

    Crizotinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Crizotinib. Read the label on DailyMed ›

Effects for Crizotinib come from the ADVERSE REACTIONS section of its FDA label; effects for Basil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 12,638 voluntary FDA FAERS reports for Crizotinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Basil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When the above ground parts are used in amounts commonly found in foods.

Pregnancy And Lactation Possibly Unsafe

When used in larger amounts due to the estragole constituent of the essential oil. Estragole might have mutagenic effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Basil or Crizotinib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Basil or Crizotinib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Crizotinib

This page covers Basil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crizotinib page lists 157 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 112 moderate · 37 minor.

From our pharmacist’s overview on the Crizotinib page

“Grapefruit tops my worry list for crizotinib (Xalkori), a targeted pill for ALK-positive lung cancer. It blocks the enzyme (CYP3A4) that clears crizotinib, letting levels climb and side effects with them, and it is one of eight major-rated entries among the 157 supplements and herbs on file for this drug.”

Reviewed by 2 · Jul 18, 2026

Open the Crizotinib interaction page

One more smart check

Taking Basil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 396 real supplement products containing Basil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Basil. Even though Basil itself has no known interaction with Crizotinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Basil and Crizotinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Basil
Top half

#368 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Crizotinib
Steady interest

#2,053 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Basil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Basil and Crizotinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Basil

What is Basil?

Basil
  • Digestive upset and gas
  • Stress and anxiety
  • Antimicrobial support
  • Cold and cough symptoms
  • Headache
  • General antioxidant support

Basil is a popular cooking herb that is generally safe in the amounts used in food. While it has a long history of traditional medicinal use and contains antioxidant compounds, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements or essential oils.

Ocimum basilicum · Lamiaceae · Leaves, flowering tops, seeds, and essential oil · Fresh or dried leaves, culinary herb, tea, capsules, extracts, and essential oil

An interaction check asks whether these two react with each other — it does not ask whether Basil is a good idea for someone in your situation. Here is what our Basil record says about it on its own.

Basil: dosing

There is no well-established standard medicinal dose for basil. As a food and seasoning, it is used freely to taste with no special precautions for most people.For supplements, teas, or extracts, the right amount is not clearly defined by research. Follow the directions on the product label and do not exceed them.

From our Basil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Basil monograph & all interactions
Medication

About Crizotinib

What Is Crizotinib Used For?

Brand name: Xalkori

Xalkori (crizotinib) is used to treat adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors test positive for the ALK or ROS1 gene abnormality, as confirmed by an FDA-approved test.

Xalkori is also used to treat pediatric patients aged 1 year and older and young adults with relapsed or refractory systemic ALK-positive anaplastic large cell lymphoma (ALCL). Additionally, it treats adult and pediatric patients aged 1 year and older with unresectable, recurrent, or refractory ALK-positive inflammatory myofibroblastic tumor (IMT). Note: Xalkori's safety and effectiveness in older adults with relapsed or refractory ALK-positive ALCL have not been established.

Most-Reported Side Effects for Crizotinib

From FAERS, the FDA’s public side-effect reporting system (12,638 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 1,216 reports
Nausea 1,118 reports
Neoplasm progression 1,112 reports
Diarrhea 846 reports
Vomiting 795 reports
See full Crizotinib drug information
Keep checking

Other Drugs & Basil

Browse every other medication we’ve checked against Basil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
289Moderate
0Minor
2,540No known interaction
289 Moderate 2,540 No interaction
Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Basil page.

No interaction 2,540 drugs checked — show the list

We also checked Basil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Basil list.

See the full Basil interactions page
See every supplement checked against Crizotinib, ranked by severity
Evidence & sources

Basil References

The 7 references that drive our Basil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  4. Tohti, I., Tursun, M., Umar, A., Turdi, S., Imin, H., and Moore, N. Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio--venous shunt thrombosis in vivo. Thromb.Res 200 PubMed
  5. Amrani, S., Harnafi, H., Gadi, D., Mekhfi, H., Legssyer, A., Aziz, M., Martin-Nizard, F., and Bosca, L. Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. J Ethnopharmacol. 8-17-2009;125(1):157-162. PubMed
  6. Umar, A., Imam, G., Yimin, W., Kerim, P., Tohti, I., Berke, B., and Moore, N. Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. Hypertens.Res 5-7-2010; PubMed
  7. Kiec-Swierczynska M, Krecisz B, Chomiczewska D, et al. Occupational allergic contact dermatitis caused by basil (Ocimum basilicum). Contact Dermatitis 2010;63(6):365-7.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Basil and Crizotinib Together: Common Questions

Is it safe to take Basil with Crizotinib?
We do not list a known interaction between Basil and Crizotinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Basil and Crizotinib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Basil and Crizotinib combination checked?
Interactions in our licensed database are recorded against drug classes. Crizotinib is filed under 5 classifications, and Basil has documented interactions with 2 drug classes — none of Crizotinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Basil interact with any other medications?
Yes. Basil has 289 documented drug interactions in our database — Crizotinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Crizotinib interact with any supplements?
Yes. Crizotinib has documented interactions with 157 supplements in our database — Basil is not one of them. The Crizotinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Basil monograph Uses, safety profile, and every drug interaction in one place Crizotinib drug information The full plain-English guide to this medication Crizotinib supplement interactions Every supplement checked against Crizotinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Crizotinib and Basil?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.