Drug & supplement interaction

Belladonna + Uridine Triacetate

Uridine Triacetate brand names: Xuriden, Vistogard.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Belladonna and Uridine Triacetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Uridine Triacetate states a food rule worth keeping to.

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Interaction report

Belladonna and Uridine Triacetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Uridine Triacetate and Belladonna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Belladonna safety at a glance

Belladonna overall Avoid Belladonna is poisonous and unsafe to take on your own outside of regulated, professionally supervised products.
Pregnancy Avoid Avoid during pregnancy because belladonna's alkaloids are toxic and effects on the baby are not established.
Breastfeeding Likely Unsafe When used orally. Belladonna can reduce milk production and is secreted into breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Uridine Triacetate and Belladonna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Uridine Triacetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Uridine Triacetate is filed under a single classification — oral drugs. Belladonna has documented interactions with 2 drug classes — the most serious being anticholinergic drugs (moderate) and cisapride (propulsid) (moderate) — and none of Uridine Triacetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Belladonna Does Interact With Other Medications

Belladonna has 196 moderate known drug interactions in our database — Uridine Triacetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 196 No known interaction 2,634 (incl. Uridine Triacetate)
Taking anything else?

Check Another of Your Medications Against Belladonna

Covers the 2,830 medications we’ve checked against Belladonna. Pick one to open its full report.

What to actually watch for

What Belladonna Itself Has Been Linked To

This is not an interaction — nothing below involves Uridine Triacetate. It is the side-effect record for Belladonna on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Belladonna, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

  • Trouble passing urine Worth acting on Additional detail

    “Orally, belladonna can cause anticholinergic side effects such as urinary retention.”

    Belladonna · Natural Medicines adverse-effect record, reported in urinary retention.

    4 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34145. Heindl, S., Binder, C., Desel, H., Matthies, U., Lojewski, I., Bandelow, B., Kahl, G. F., and Chemnitius, J. M. [Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagn
    3. 34150. Davidov, M. I. [Factors predisposing to acute urine retention in patients with prostatic adenoma]. Urologiia. 2007;(2):25-31.
    4. 34163. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204(2):169-170. DOI
  • Hallucinations Worth acting on Additional detail

    “Orally, belladonna can cause anticholinergic side effects even at low doses, and is considered poisonous.

    Most Common Adverse Effects:

    Orally: Anticholinergic side effects, including blurred vision, constipation, delirium, dilated pupils, dizziness, dry mouth, fever, headache, hypertension, muscle rigidity and tremor, psychosis, respiratory failure, and slurred speech.”

    Belladonna · Natural Medicines adverse-effect record, reported in cluster headache.

  • Confusion Worth acting on Additional detail

    “Orally, belladonna can cause anticholinergic side effects such as memory and attention impairment, headache, and confusion.”

    Belladonna · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34163. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204(2):169-170. DOI
    3. 34180. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204(11):153. DOI
  • Raised blood pressure Worth acting on Additional detail

    “Orally, belladonna can cause anticholinergic side effects such as hypertension, hypotension, tachycardia, and ventricular premature beats.”

    Belladonna · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34168. Schneider, F., Lutun, P., Kintz, P., Astruc, D., Flesch, F., and Tempe, J. D. Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 1996;34(1):113-117. PubMed
    3. 34180. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204(11):153. DOI
  • Hives Worth acting on Additional detail

    “Orally, belladonna can cause anticholinergic side effects such as dry, red skin and decreased perspiration. One case of rash and another case of hives have been reported in patients taking belladonna with phenobarbital and ergotamine orally; it is unclear if the adverse effects were due to belladonna or the other ingredients.

    Topically, belladonna plaster (Cuxon Gerrard) can cause contact dermatitis.”

    Belladonna · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34146. Walach, H., Koster, H., Hennig, T., and Haag, G. The effects of homeopathic belladonna 30CH in healthy volunteers -- a randomized, double-blind experiment. J.Psychosom.Res. 2001;50(3):155-160. PubMed
    3. 34152. Williams HC and du Vivier A. Belladonna plaster--not as bella as it seems. Contact Dermatitis 1990;23(2):119-120.
    4. 34154. Stieg, R. L. Double-blind study of belladonna-ergotamine-phenobarbital for interval treatment of recurrent throbbing headache. Headache 1977;17(3):120-124. PubMed
  • Tremor or shakiness Additional detail

    Recorded for Belladonna in the same Natural Medicines adverse-effect record shown under Hallucinations above.

  • Blurred vision Additional detail

    “Orally and topically, belladonna can cause anticholinergic side effects such as dilation of pupils and blurred vision. A case report describes anisocoria (unequal pupil sizes) in a 70-year-old female who used homeopathic pink eye relief drops (Similasan) containing belladonna, eyebright, and hepar sulphuris (calcium sulfide) in one eye for 3 days.”

    Belladonna · Natural Medicines adverse-effect record, reported in glaucoma.

    6 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34157. Shader RI and Greenblatt DJ. Uses and toxicity of belladonna alkaloids and synthetic anticholinergics. Seminars in Psychiatry 1971;3(4):449-476.
    3. 34168. Schneider, F., Lutun, P., Kintz, P., Astruc, D., Flesch, F., and Tempe, J. D. Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 1996;34(1):113-117. PubMed
    4. 34169. Ceha LJ, Presperin C, Young E, and et al. Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine. The Journal of Emergency Medicine 1997;15(1):65-69. PubMed
    5. 34180. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204(11):153. DOI
    6. 106907. Chen L, Yeung JC, Anderson DR. Anisocoria secondary to anticholinergic mydriasis from homeopathic pink eye relief drops. Clin Med Res. 2017;15(3-4):93-5. PubMed
  • Sweating Additional detail

    Recorded for Belladonna in the same Natural Medicines adverse-effect record shown under Hives above.

  • Dry mouth Additional detail

    “Orally, belladonna can cause anticholinergic side effects such as dry mouth and constipation.”

    Belladonna · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 553. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
    2. 34162. Gabel MC. Purposeful ingestion of belladonna for hallucinatory effects. J.Pediatr. 1968;72(6):864-866. PubMed
    3. 34163. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204(2):169-170. DOI
    4. 34176. Firth D and Bentley JR. Belladonna poisoning from eating rabbit. Lancet 1921;2:901. DOI
    5. 34180. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204(11):153. DOI
    6. 34181. Hamilton M and Sclare AB. Belladonna poisoning. Br Med J 1947;611-612. PubMed
  • A fast or pounding heartbeat Additional detail

    Recorded for Belladonna in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

Showing the 10 most notable of 16 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Belladonna — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Uridine Triacetate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Uridine Triacetate column appears here.

Special populations

Belladonna in Pregnancy & Breastfeeding

Lactation Likely Unsafe

When used orally. Belladonna can reduce milk production and is secreted into breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Uridine Triacetate Products Have a Food Rule — Belladonna Should Not Break It

At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Belladonna on an empty stomach out of habit, keep them separate — and take Uridine Triacetate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Uridine Triacetate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer the dose with food (applesauce, pudding or yogurt) or in milk or infant formula.

From the Dosage and Administration section of the FDA label we read for Uridine Triacetate — where that label names a specific product, the instruction is that product's. See the Uridine Triacetate drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Uridine Triacetate

This page covers Belladonna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Uridine Triacetate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Uridine Triacetate page

“Uridine triacetate is a drug you take when absorption truly cannot fail, whether as Vistogard, the emergency antidote for fluorouracil or capecitabine overdose, or as Xuriden for hereditary orotic aciduria. That is why the 17 supplement interactions on file deserve real care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Uridine Triacetate interaction page

One more smart check

Taking Belladonna as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Belladonna, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Belladonna. Even though Belladonna itself has no known interaction with Uridine Triacetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Belladonna and Uridine Triacetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Belladonna
Steady interest

#1,027 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Uridine Triacetate
Steady interest

#2,711 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Belladonna reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Belladonna and Uridine Triacetate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Belladonna

What is Belladonna?

  • Digestive cramps and spasms
  • Cold and flu symptoms (homeopathic)
  • Teething pain (homeopathic)
  • Motion sickness and nausea
  • Excess sweating or secretions
  • Pain and muscle spasm (topical plasters)

Belladonna is a highly toxic plant whose alkaloids (like atropine and scopolamine) are powerful medicines used only in carefully controlled, regulated forms. The raw plant and unregulated products can cause serious poisoning, and homeopathic versions have little proof of benefit. Never self-treat with belladonna without guidance from a doctor or pharmacist.

Atropa belladonna · Solanaceae · Leaves, roots, and berries · Homeopathic tablets and pellets, tinctures, topical plasters, and standardized prescription alkaloid extracts

An interaction check asks whether these two react with each other — it does not ask whether Belladonna is a good idea for someone in your situation. Here is what our Belladonna record says about it on its own.

Belladonna: dosing

There is no safe, established "supplement" dose of belladonna for self-care. The line between a helpful dose and a toxic dose is dangerously narrow, and the amount of alkaloid in raw plant material can vary widely.Prescription belladonna-alkaloid medicines are dosed by a doctor and pharmacist. Homeopathic products are highly diluted and labeled in their own units; follow the product label exactly and keep them away from children.Do not try to make or dose belladonna products yourself.

From our Belladonna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Belladonna monograph & all interactions
Medication

About Uridine Triacetate

What Is Uridine Triacetate Used For?

Brand names: Xuriden, Vistogard

Uridine triacetate is available as two different products for two distinct uses. Vistogard is used for emergency treatment after an overdose of the chemotherapy drugs fluorouracil or capecitabine — or when someone develops severe, early, or life-threatening side effects from those drugs (such as heart or nervous system problems, severe digestive reactions, or a dangerous drop in white blood cells) within 96 hours of their last dose.

Xuriden is used to treat hereditary orotic aciduria, a rare inherited condition in which the body cannot make enough of a building block called uridine, causing a buildup of orotic acid and problems with blood cell production and other body functions. Both products are approved for adults and children.

See full Uridine Triacetate drug information
Keep checking

Other Drugs & Belladonna

Browse every other medication we’ve checked against Belladonna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
196Moderate
0Minor
2,633No known interaction
196 Moderate 2,633 No interaction
Moderate

196 interactions

Showing 60 of 196 moderate interactions — see all 196 on the Belladonna page.

No interaction 2,633 drugs checked — show the list

We also checked Belladonna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,633 medications checked with no known interaction — see the full Belladonna list.

See the full Belladonna interactions page
See every supplement checked against Uridine Triacetate, ranked by severity
Evidence & sources

Belladonna References

The 20 references that drive our Belladonna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  5. Corazziari, E., Bontempo, I., and Anzini, F. Effects of cisapride on distal esophageal motility in humans. Dig Dis Sci 1989;34(10):1600-1605. PubMed
  6. Heindl, S., Binder, C., Desel, H., Matthies, U., Lojewski, I., Bandelow, B., Kahl, G. F., and Chemnitius, J. M. [Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagn
  7. Walach, H., Koster, H., Hennig, T., and Haag, G. The effects of homeopathic belladonna 30CH in healthy volunteers -- a randomized, double-blind experiment. J.Psychosom.Res. 2001;50(3):155-160. PubMed
  8. Davidov, M. I. [Factors predisposing to acute urine retention in patients with prostatic adenoma]. Urologiia. 2007;(2):25-31.
  9. Williams HC and du Vivier A. Belladonna plaster--not as bella as it seems. Contact Dermatitis 1990;23(2):119-120.
  10. Stieg, R. L. Double-blind study of belladonna-ergotamine-phenobarbital for interval treatment of recurrent throbbing headache. Headache 1977;17(3):120-124. PubMed
  11. Shader RI and Greenblatt DJ. Uses and toxicity of belladonna alkaloids and synthetic anticholinergics. Seminars in Psychiatry 1971;3(4):449-476.
  12. Gabel MC. Purposeful ingestion of belladonna for hallucinatory effects. J.Pediatr. 1968;72(6):864-866. PubMed
  13. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204(2):169-170. DOI
  14. Schneider, F., Lutun, P., Kintz, P., Astruc, D., Flesch, F., and Tempe, J. D. Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 1996;34(1):113-117. PubMed
  15. Ceha LJ, Presperin C, Young E, and et al. Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine. The Journal of Emergency Medicine 1997;15(1):65-69. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Belladonna and Uridine Triacetate Together: Common Questions

Is it safe to take Belladonna with Uridine Triacetate?
We do not list a known interaction between Belladonna and Uridine Triacetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Belladonna and Uridine Triacetate at the same time of day?
At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Belladonna on an empty stomach out of habit, keep them separate and take Uridine Triacetate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Uridine Triacetate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Belladonna and Uridine Triacetate combination checked?
Interactions in our licensed database are recorded against drug classes. Uridine Triacetate is filed under 1 classification, and Belladonna has documented interactions with 2 drug classes — none of Uridine Triacetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Belladonna interact with any other medications?
Yes. Belladonna has 196 documented drug interactions in our database — Uridine Triacetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Uridine Triacetate interact with any supplements?
Yes. Uridine Triacetate has documented interactions with 17 supplements in our database — Belladonna is not one of them. The Uridine Triacetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Belladonna monograph Uses, safety profile, and every drug interaction in one place Uridine Triacetate drug information The full plain-English guide to this medication Uridine Triacetate supplement interactions Every supplement checked against Uridine Triacetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Uridine Triacetate and Belladonna?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.