Drug & supplement interaction

Brussels Sprout + Pralsetinib

Pralsetinib brand name: Gavreto.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Brussels Sprout and Pralsetinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pralsetinib states a food rule worth keeping to.

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Interaction report

Brussels Sprout and Pralsetinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pralsetinib and Brussels Sprout in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Brussels Sprout safety at a glance

Brussels Sprout overall Generally safe Generally safe and healthy when eaten as a normal food.
Pregnancy Generally safe Safe to eat in normal food amounts during pregnancy; concentrated supplements are not well studied.
Breastfeeding Generally safe Safe as a food while breastfeeding; concentrated extracts have not been studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pralsetinib and Brussels Sprout? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pralsetinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pralsetinib is filed under 5 classifications — including qt interval-prolonging drugs, p-glycoprotein substrates, hepatotoxic drugs. Brussels Sprout has documented interactions with 5 drug classes — the most serious being acetaminophen (tylenol, others) (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and glucuronidated drugs (moderate) — and none of Pralsetinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Brussels Sprout Does Interact With Other Medications

Brussels Sprout has 241 moderate known drug interactions in our database — Pralsetinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 241 No known interaction 2,589 (incl. Pralsetinib)
Taking anything else?

Check Another of Your Medications Against Brussels Sprout

Covers the 2,830 medications we’ve checked against Brussels Sprout. Pick one to open its full report.

What to actually watch for

What Brussels Sprout Itself Has Been Linked To

This is not an interaction — nothing below involves Pralsetinib. It is the side-effect record for Brussels Sprout on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Brussels Sprout, this list is the first place to look.

  • Bloating or gas Additional detail

    “Orally, Brussels sprout is generally well-tolerated when consumed in dietary amounts. Eating Brussels sprout or other types of fermentable carbohydrates can cause flatulence.”

    Brussels Sprout · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 26470. Allaby RG, Peterson GW, Merriwether DA, Fu YB. Evidence of the domestication history of flax (Linum usitatissimum L.) from genetic diversity of the sad2 locus. Theor Appl Genet. 2005 Dec;112(1):58-65. PubMed

    “Orally, eating Brussels sprout or other types of fermentable carbohydrates can cause flatulence.”

    Brussels Sprout · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 26470. Allaby RG, Peterson GW, Merriwether DA, Fu YB. Evidence of the domestication history of flax (Linum usitatissimum L.) from genetic diversity of the sad2 locus. Theor Appl Genet. 2005 Dec;112(1):58-65. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Brussels Sprout — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Pralsetinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Pralsetinib column appears here.

How to take them

Some Pralsetinib Products Have a Food Rule — Brussels Sprout Should Not Break It

At least one FDA label for a product containing Pralsetinib says to take it on an empty stomach. Most supplements — Brussels Sprout included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Pralsetinib on its own and move Brussels Sprout to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pralsetinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 14 ) The recommended dosage in adults and pediatric patients 12 years and older is 400 mg orally once daily on an empty stomach (no food intake for at least 2 hours before and at least 1 hour after taking GAVRETO).

From the Dosage and Administration section of the FDA label we read for Pralsetinib — where that label names a specific product, the instruction is that product's. See the Pralsetinib drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Pralsetinib Is Prescribed For, and What Brussels Sprout Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Pralsetinib is a prescription medicine with approved uses on its FDA label. Brussels Sprout is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Pralsetinib is prescribed for: Gavreto (pralsetinib) is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic alteration detected by an FDA-approved test. Gavreto is also approved for adults and children aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who need systemic (whole-body) treatment and whose cancer no longer responds to radioactive iodine (when radioactive iodine is an appropriate option). This thyroid cancer use is under accelerated approval, meaning continued approval depends on results from confirmatory clinical trials.

Brussels Sprout has been studied for:

  • Lung cancer studied, not established Brussels Sprout has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Brussels Sprout for lung cancer

    Population research has found that people who consume Brussels sprout and broccoli at least once weekly have a 22% lower risk of developing lung cancer when compared with those who consume these vegetables less than once monthly.

    1 source cited
    1. 26192. Brennan P, Hsu CC, Moullan N, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet 2005;366(9496):1558-60. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pralsetinib on your own; if you are taking Brussels Sprout for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Pralsetinib

This page covers Brussels Sprout only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pralsetinib page lists 181 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 134 moderate · 36 minor.

From our pharmacist’s overview on the Pralsetinib page

“With pralsetinib (Gavreto), a targeted therapy for RET-driven lung and thyroid cancers, I would treat this list as required reading rather than background noise. Most of the interactions change how much of the drug the body actually gets: grapefruit can push its levels higher, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Pralsetinib interaction page

How much people look this up

Where Brussels Sprout and Pralsetinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Brussels Sprout
Steady interest

#833 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pralsetinib
Steady interest

#2,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Brussels Sprout reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Brussels Sprout and Pralsetinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Brussels Sprout

What is Brussels Sprout?

  • General nutrition and fiber
  • Antioxidant support
  • Digestive health
  • Heart health support
  • Cancer-prevention interest

Brussels sprouts are a nutritious cruciferous vegetable rich in fiber, vitamin C, vitamin K, and plant compounds called glucosinolates. Eating them as part of a balanced diet is healthy and safe for most people, but supplement-style claims (like preventing cancer) are not well proven. If you take blood thinners or have thyroid concerns, talk with your pharmacist or doctor about your intake.

Brassica oleracea var. gemmifera · Brassicaceae · Edible sprouts (small leafy buds) · Fresh or cooked vegetable, frozen, powdered, capsule or extract supplements

An interaction check asks whether these two react with each other — it does not ask whether Brussels Sprout is a good idea for someone in your situation. Here is what our Brussels Sprout record says about it on its own.

Brussels Sprout: dosing

There is no official "dose" for Brussels sprouts because they are a food, not a drug. A normal serving as part of meals is appropriate for most people, and they can be enjoyed several times a week as part of a vegetable-rich diet.If you choose a Brussels sprout or cruciferous vegetable supplement, there is no standardized, proven dose.

From our Brussels Sprout monograph — the full record covers uses, side effects and every documented interaction.

Read the full Brussels Sprout monograph & all interactions
Medication

About Pralsetinib

What Is Pralsetinib Used For?

Brand name: Gavreto

Gavreto (pralsetinib) is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic alteration detected by an FDA-approved test.

Gavreto is also approved for adults and children aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who need systemic (whole-body) treatment and whose cancer no longer responds to radioactive iodine (when radioactive iodine is an appropriate option). This thyroid cancer use is under accelerated approval, meaning continued approval depends on results from confirmatory clinical trials.

Most-Reported Side Effects for Pralsetinib

From FAERS, the FDA’s public side-effect reporting system (1,788 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Product prescribing issue 181 reports
Fatigue 126 reports
Asthenia 116 reports
Anemia 98 reports
Hypertension 96 reports
See full Pralsetinib drug information
Keep checking

Other Drugs & Brussels Sprout

Browse every other medication we’ve checked against Brussels Sprout — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
241Moderate
0Minor
2,588No known interaction
241 Moderate 2,588 No interaction
Moderate

241 interactions

Showing 60 of 241 moderate interactions — see all 241 on the Brussels Sprout page.

No interaction 2,588 drugs checked — show the list

We also checked Brussels Sprout against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,588 medications checked with no known interaction — see the full Brussels Sprout list.

See the full Brussels Sprout interactions page
See every supplement checked against Pralsetinib, ranked by severity
Evidence & sources

Brussels Sprout References

The 19 references that drive our Brussels Sprout monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  2. Joshipura KJ, Ascherio A, Manson JE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999;282:1233-39. PubMed
  3. Zhao H, Lin J, Grossman HB, et al. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int J Cancer 2007;120:2208-13.
  4. Cohen, J. H., Kristal, A. R., and Stanford, J. L. Fruit and vegetable intakes and prostate cancer risk. J Natl.Cancer Inst. 1-5-2000;92(1):61-68. PubMed
  5. Kolonel, L. N., Hankin, J. H., Whittemore, A. S., Wu, A. H., Gallagher, R. P., Wilkens, L. R., John, E. M., Howe, G. R., Dreon, D. M., West, D. W., and Paffenbarger, R. S., Jr. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control st
  6. Kissel JT, Scott CB, Reyna SP, Crawford TO, Simard LR, Krosschell KJ, Acsadi G, Elsheik B, Schroth MK, D'Anjou G, LaSalle B, Prior TW, Sorenson S, Maczulski JA, Bromberg MB, Chan GM, Swoboda KJ; Project Cure Spinal Muscular Atrophy Investigators' Network.
  7. Ovesen L, Lyduch S, Idorn ML. The effect of a diet rich in Brussels sprouts on warfarin pharmacokinetics. Eur J Clin Pharmacol 1998;34(5):521-523. PubMed
  8. Wortelboer HM, de Kruif CA, van Iersel AAJ, et al. Effects of cooked Brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat. Food Chem Toxicol 1992;30(1):17-27. PubMed
  9. Michaud DS, Spiegelman D, Clinton SK, et al. Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst 1999;91(7):605-13. PubMed
  10. Chang ET, Smedby KE, Zhang SM, et al. Dietary factors and risk of non-Hodgkin lymphoma in men and women. Cancer Epidemiol Biomarkers Prev 2005;14(2):512-20. PubMed
  11. Liu S, Serdula M, Janket SJ, et al. A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women. Diabetes Care 2004;27(12):2993-6. PubMed
  12. Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev 2004;13(9):1485-94. DOI
  13. Smith-Warner SA, Spiegelman D, Yaun SS, et al. Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. JAMA 2001;285(6):769-76.
  14. Rohrmann S, Giovannucci E, Willett WC, Platz EA. Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men. Am J Clin Nutr 2007;85(2):523-9. PubMed
  15. Brennan P, Hsu CC, Moullan N, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet 2005;366(9496):1558-60. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Brussels Sprout and Pralsetinib Together: Common Questions

Is it safe to take Brussels Sprout with Pralsetinib?
We do not list a known interaction between Brussels Sprout and Pralsetinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Brussels Sprout and Pralsetinib at the same time of day?
At least one FDA label for a product containing Pralsetinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Pralsetinib on its own and move Brussels Sprout to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Are Brussels Sprout and Pralsetinib used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Brussels Sprout in each. That is a conversation for your prescriber, especially if Pralsetinib is being adjusted to a target.
How was the Brussels Sprout and Pralsetinib combination checked?
Interactions in our licensed database are recorded against drug classes. Pralsetinib is filed under 5 classifications, and Brussels Sprout has documented interactions with 5 drug classes — none of Pralsetinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Brussels Sprout interact with any other medications?
Yes. Brussels Sprout has 241 documented drug interactions in our database — Pralsetinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pralsetinib interact with any supplements?
Yes. Pralsetinib has documented interactions with 181 supplements in our database — Brussels Sprout is not one of them. The Pralsetinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Brussels Sprout monograph Uses, safety profile, and every drug interaction in one place Pralsetinib drug information The full plain-English guide to this medication Pralsetinib supplement interactions Every supplement checked against Pralsetinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 19 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.