Drug & supplement interaction

Calea Zacatechichi + Psyllium (OTC drug)

Psyllium (OTC drug) brand name: Metamucil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Calea Zacatechichi and Psyllium (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Calea Zacatechichi and Psyllium (OTC drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Psyllium (OTC drug) and Calea Zacatechichi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calea Zacatechichi safety at a glance

Calea Zacatechichi overall Use caution It has a long folk-use history but little modern safety data, and it can cause nausea and vomiting.
Pregnancy Avoid There is no reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Psyllium (OTC drug) and Calea Zacatechichi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Psyllium (OTC drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Psyllium (OTC drug) is filed under a single classification — oral drugs. Calea Zacatechichi has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (minor) and cns depressants (minor) — and none of Psyllium (OTC drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calea Zacatechichi Does Interact With Other Medications

Calea Zacatechichi has 334 minor known drug interactions in our database — Psyllium (OTC drug) isn’t one of them. If you take anything else, check it against the full list below.

Minor 334 No known interaction 2,496 (incl. Psyllium (OTC drug))
Taking anything else?

Check Another of Your Medications Against Calea Zacatechichi

Covers the 2,830 medications we’ve checked against Calea Zacatechichi. Pick one to open its full report.

What to actually watch for

What Calea Zacatechichi Itself Has Been Linked To

This is not an interaction — nothing below involves Psyllium (OTC drug). It is the side-effect record for Calea Zacatechichi on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Calea Zacatechichi, this list is the first place to look.

  • Drowsiness Additional detail

    “There is currently a limited amount of information on the adverse effects of Calea zacatechichi. Observations in healthy volunteers indicate that it is bitter tasting and may cause vomiting and somnolence.”

    Calea Zacatechichi · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    “In healthy volunteers, a methanol extract of Calea zacatechichi produces somnolence with short periods of light sleep and decreases in deep slow-wave sleep and rapid eye movement (REM) sleep.”

    Calea Zacatechichi · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 23602. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  • Vomiting Additional detail

    “Observations in healthy volunteers indicate that Calea zacatechichi is bitter tasting and can cause nausea, vomiting, and retching.”

    Calea Zacatechichi · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 23602. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  • Nausea Additional detail

    Recorded for Calea Zacatechichi in the same Natural Medicines adverse-effect record shown under Vomiting above.

Everything above comes from the Natural Medicines adverse-effect record for Calea Zacatechichi — expand a row for the licensed statement it rests on. We haven’t matched Psyllium (OTC drug) to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Psyllium (OTC drug).

From our Q&A

Questions About Calea Zacatechichi or Psyllium (OTC drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calea Zacatechichi or Psyllium (OTC drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Psyllium (OTC drug)

This page covers Calea Zacatechichi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Psyllium (OTC drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Psyllium (OTC drug) page

“Activated charcoal tops the psyllium (Metamucil) list and is the one entry rated major. Charcoal binds many medicines in the gut and can cut how much of them reaches the body, so pairing it with anything you take by mouth deserves real caution, and I would read that entry before the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Psyllium (OTC drug) interaction page

One more smart check

Taking Calea Zacatechichi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 21 real supplement products containing Calea Zacatechichi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calea Zacatechichi. Even though Calea Zacatechichi itself has no known interaction with Psyllium (OTC drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calea Zacatechichi and Psyllium (OTC drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calea Zacatechichi
Steady interest

#795 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Psyllium (OTC drug)
Top half

#936 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calea Zacatechichi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Calea Zacatechichi and Psyllium (OTC drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calea Zacatechichi

What is Calea Zacatechichi?

  • Promoting vivid or lucid dreams
  • Sleep and relaxation
  • Digestive upset
  • Fever
  • Traditional ritual use

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so its benefits are not well proven, and its safety has not been carefully studied. It tastes very bitter, can cause nausea, and should be avoided during pregnancy and breastfeeding.

Calea ternifolia · Asteraceae · Leaves and flowering tops (dried) · Dried leaf tea, capsules, tincture/liquid extract, and smoked dried leaf

An interaction check asks whether these two react with each other — it does not ask whether Calea Zacatechichi is a good idea for someone in your situation. Here is what our Calea Zacatechichi record says about it on its own.

Calea Zacatechichi: dosing

There is no established or standardized dose for Calea zacatechichi. The amount of active compounds can vary a lot from product to product, which makes safe dosing hard to judge.If you choose to use it, follow the directions on the product label and do not exceed them.

From our Calea Zacatechichi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calea Zacatechichi monograph & all interactions
Medication

About Psyllium

What Is Psyllium Used For?

Brand name: Metamucil

Psyllium is used to treat occasional constipation and help restore regularity. It is available under many brand names — including Careone, Best Choice, Premier Value Fiber, fiber laxative, meijer fiber laxative, Publix, Best Choice Fiber Therapy, Daily Fiber, Dr. Fibra, Lidl Orange Smooth Fiber Powder, and meijer fiber therapy — all for this same purpose.

Most products note that psyllium generally produces a bowel movement within 12 to 72 hours of taking a dose.

See full Psyllium drug information
Keep checking

Other Drugs & Calea Zacatechichi

Browse every other medication we’ve checked against Calea Zacatechichi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
334Minor
2,495No known interaction
334 Minor 2,495 No interaction
Minor

334 interactions

Showing 60 of 334 minor interactions — see all 334 on the Calea Zacatechichi page.

No interaction 2,495 drugs checked — show the list

We also checked Calea Zacatechichi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Calea Zacatechichi list.

See the full Calea Zacatechichi interactions page
See every supplement checked against Psyllium (OTC drug), ranked by severity
Evidence & sources

Calea Zacatechichi References

The 2 references that drive our Calea Zacatechichi monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calea Zacatechichi and Psyllium (OTC drug) Together: Common Questions

Is it safe to take Calea Zacatechichi with Psyllium (OTC drug)?
We do not list a known interaction between Calea Zacatechichi and Psyllium (OTC drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Calea Zacatechichi and Psyllium (OTC drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Psyllium (OTC drug) is filed under 1 classification, and Calea Zacatechichi has documented interactions with 2 drug classes — none of Psyllium (OTC drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calea Zacatechichi interact with any other medications?
Yes. Calea Zacatechichi has 334 documented drug interactions in our database — Psyllium (OTC drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Psyllium (OTC drug) interact with any supplements?
Yes. Psyllium (OTC drug) has documented interactions with 17 supplements in our database — Calea Zacatechichi is not one of them. The Psyllium (OTC drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calea Zacatechichi monograph Uses, safety profile, and every drug interaction in one place Psyllium drug information The full plain-English guide to this medication Psyllium (OTC drug) supplement interactions Every supplement checked against Psyllium (OTC drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Psyllium (OTC drug) and Calea Zacatechichi?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.