Drug & supplement interaction

Calea Zacatechichi + Doxycycline

Doxycycline brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Calea Zacatechichi and Doxycycline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxycycline states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Calea Zacatechichi and Doxycycline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxycycline and Calea Zacatechichi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calea Zacatechichi safety at a glance

Calea Zacatechichi overall Use caution It has a long folk-use history but little modern safety data, and it can cause nausea and vomiting.
Pregnancy Avoid There is no reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxycycline and Calea Zacatechichi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Doxycycline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxycycline is filed under 9 classifications — including tetracycline antibiotics, antibiotic drugs, p-glycoprotein substrates. Calea Zacatechichi has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (minor) and cns depressants (minor) — and none of Doxycycline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calea Zacatechichi Does Interact With Other Medications

Calea Zacatechichi has 334 minor known drug interactions in our database — Doxycycline isn’t one of them. If you take anything else, check it against the full list below.

Minor 334 No known interaction 2,496 (incl. Doxycycline)
Taking anything else?

Check Another of Your Medications Against Calea Zacatechichi

Covers the 2,830 medications we’ve checked against Calea Zacatechichi. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Calea Zacatechichi and Doxycycline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Calea Zacatechichi

    “There is currently a limited amount of information on the adverse effects of Calea zacatechichi. Observations in healthy volunteers indicate that it is bitter tasting and may cause vomiting and somnolence.”

    Calea Zacatechichi · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    “Observations in healthy volunteers indicate that Calea zacatechichi is bitter tasting and can cause nausea, vomiting, and retching.”

    Calea Zacatechichi · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 23602. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed

    Doxycycline

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›

  • Nausea Additional detail

    Calea Zacatechichi

    Recorded for Calea Zacatechichi in the same Natural Medicines adverse-effect record shown under Vomiting above.

    Doxycycline

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›

Reported for Calea Zacatechichi but not commonly for Doxycycline: drowsiness.

Effects for Doxycycline come from the ADVERSE REACTIONS section of its FDA label; effects for Calea Zacatechichi come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Doxycycline Products Have a Food Rule — Calea Zacatechichi Should Not Break It

At least one FDA label for a product containing Doxycycline says to take it on an empty stomach. Most supplements — Calea Zacatechichi included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxycycline on its own and move Calea Zacatechichi to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxycycline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take one Doxycycline capsule (40 mg) once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals.

From the Dosage and Administration section of the FDA label we read for Doxycycline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Doxycycline Is Prescribed For, and What Calea Zacatechichi Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Doxycycline is a prescription medicine with approved uses on its FDA label. Calea Zacatechichi is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Doxycycline is prescribed for: Doxycycline belongs to the tetracycline family of antibiotics. It's prescribed for many types of bacterial infections, including respiratory tract infections, sexually transmitted infections (STIs), tick-borne illnesses like Rocky Mountain spotted fever, and eye infections. It's also used to help prevent malaria and, in some cases, as a helper treatment for severe acne. In situations where penicillin-type antibiotics can't be used — due to allergy, for example — doxycycline can step in as an alternative.

Read the rest of what Doxycycline is prescribed for

It should only be used for infections that are proven or strongly suspected to be caused by bacteria.

Calea Zacatechichi has been studied for:

  • Malaria studied, not established Calea Zacatechichi has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Calea Zacatechichi for malaria

    Although there is interest in using oral Calea zacatechichi for malaria, there is insufficient reliable information about the clinical effects of Calea zacatechichi for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Doxycycline on your own; if you are taking Calea Zacatechichi for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Calea Zacatechichi or Doxycycline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calea Zacatechichi or Doxycycline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Doxycycline

This page covers Calea Zacatechichi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxycycline page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

By severity: 7 major · 139 moderate · 20 minor.

From our pharmacist’s overview on the Doxycycline page

“St. John's wort is the supplement I would flag first for anyone on doxycycline (Vibramycin, Doryx), because it can speed the antibiotic out of the body and leave an infection undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Doxycycline interaction page

One more smart check

Taking Calea Zacatechichi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 21 real supplement products containing Calea Zacatechichi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calea Zacatechichi. Even though Calea Zacatechichi itself has no known interaction with Doxycycline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calea Zacatechichi and Doxycycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calea Zacatechichi
Steady interest

#1,264 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxycycline
Top 5%

#41 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calea Zacatechichi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Calea Zacatechichi and Doxycycline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calea Zacatechichi

What is Calea Zacatechichi?

  • Promoting vivid or lucid dreams
  • Sleep and relaxation
  • Digestive upset
  • Fever
  • Traditional ritual use

Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive complaints and fever. Human research is very limited, so its benefits are not well proven, and its safety has not been carefully studied. It tastes very bitter, can cause nausea, and should be avoided during pregnancy and breastfeeding.

Calea ternifolia · Asteraceae · Leaves and flowering tops (dried) · Dried leaf tea, capsules, tincture/liquid extract, and smoked dried leaf

An interaction check asks whether these two react with each other — it does not ask whether Calea Zacatechichi is a good idea for someone in your situation. Here is what our Calea Zacatechichi record says about it on its own.

Calea Zacatechichi: dosing

There is no established or standardized dose for Calea zacatechichi. The amount of active compounds can vary a lot from product to product, which makes safe dosing hard to judge.If you choose to use it, follow the directions on the product label and do not exceed them.

From our Calea Zacatechichi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calea Zacatechichi monograph & all interactions
Medication

About Doxycycline

What Is Doxycycline Used For?

Brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, Doxy, Doxylin, Doxy-D, Periostat, Doxycycline Injection, Oracea, Xyrosa

Doxycycline belongs to the tetracycline family of antibiotics. It's prescribed for many types of bacterial infections, including respiratory tract infections, sexually transmitted infections (STIs), tick-borne illnesses like Rocky Mountain spotted fever, and eye infections. It's also used to help prevent malaria and, in some cases, as a helper treatment for severe acne.

In situations where penicillin-type antibiotics can't be used — due to allergy, for example — doxycycline can step in as an alternative. It should only be used for infections that are proven or strongly suspected to be caused by bacteria.

See full Doxycycline drug information
Keep checking

Other Drugs & Calea Zacatechichi

Browse every other medication we’ve checked against Calea Zacatechichi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
334Minor
2,495No known interaction
334 Minor 2,495 No interaction
Minor

334 interactions

Showing 60 of 334 minor interactions — see all 334 on the Calea Zacatechichi page.

No interaction 2,495 drugs checked — show the list

We also checked Calea Zacatechichi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Calea Zacatechichi list.

See the full Calea Zacatechichi interactions page
See every supplement checked against Doxycycline, ranked by severity
Evidence & sources

Calea Zacatechichi References

The 2 references that drive our Calea Zacatechichi monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mayagoitia, L., Diaz, J. L., Contreras, C. M. Psychopharmacologic analysis of an alleged oneirogenic plant: Calea zacatechichi. J Ethnopharmacol. 1986;18:229-243. PubMed
  2. Roman, Ramos R., Alarcon-Aguilar, F., Lara-Lemus, A., and Flores-Saenz, J. L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch.Med.Res 1992;23:59-64.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calea Zacatechichi and Doxycycline Together: Common Questions

Is it safe to take Calea Zacatechichi with Doxycycline?
We do not list a known interaction between Calea Zacatechichi and Doxycycline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Calea Zacatechichi and Doxycycline have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Calea Zacatechichi and Doxycycline at the same time of day?
At least one FDA label for a product containing Doxycycline says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxycycline on its own and move Calea Zacatechichi to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Are Calea Zacatechichi and Doxycycline used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Calea Zacatechichi in each. That is a conversation for your prescriber, especially if Doxycycline is being adjusted to a target.
How was the Calea Zacatechichi and Doxycycline combination checked?
Interactions in our licensed database are recorded against drug classes. Doxycycline is filed under 9 classifications, and Calea Zacatechichi has documented interactions with 2 drug classes — none of Doxycycline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calea Zacatechichi interact with any other medications?
Yes. Calea Zacatechichi has 334 documented drug interactions in our database — Doxycycline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Doxycycline interact with any supplements?
Yes. Doxycycline has documented interactions with 166 supplements in our database — Calea Zacatechichi is not one of them. The Doxycycline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calea Zacatechichi monograph Uses, safety profile, and every drug interaction in one place Doxycycline drug information The full plain-English guide to this medication Doxycycline supplement interactions Every supplement checked against Doxycycline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxycycline and Calea Zacatechichi?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.