Drug & supplement interaction

Cannabigerol (cbg) + Bisoprolol, Hydrochlorothiazide

Bisoprolol, Hydrochlorothiazide brand name: Ziac.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cannabigerol (cbg) has a moderate interaction with Bisoprolol, Hydrochlorothiazide. Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cannabigerol (cbg) and Bisoprolol, Hydrochlorothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Bisoprolol, Hydrochlorothiazide

Bisoprolol, Hydrochlorothiazide falls under ANTIHYPERTENSIVE DRUGS — the group Cannabigerol (cbg) interacts with.

Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that an intraperitoneal injection of cannabigerol lowers blood pressure. The mechanism of action may be related to alpha-2-adrenoreceptor activity. The effect of oral intake of cannabigerol is unclear and this has not been shown in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Ziac is a two-in-one blood pressure pill: bisoprolol (a beta-blocker that slows the heart) plus hydrochlorothiazide (a water pill). Here's the concern with CBG. In animal studies, injected CBG lowered blood pressure, possibly by acting on alpha-2 receptors. If that effect carries over to people, adding CBG on top of Ziac could push your numbers a little too low.

What might that feel like? Lightheadedness, dizziness when you stand up, tiredness, or a slower heartbeat. I want to be honest though: this is theoretical, based only on animal data, and oral CBG hasn't been shown to do this in humans. It's worth a quick chat with your pharmacist or doctor before combining them, especially while they watch your blood pressure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Vernail VL, Bingaman SS, Silberman Y, Raup-Konsavage WM, Vrana KE, Arnold AC. Acute cannabigerol administration lowers blood pressure in mice. Front Physiol 2022;13:871962. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cannabigerol (cbg) Also Interacts With Other Medications

Cannabigerol (cbg) has 171 moderate known drug interactions in our database — the Bisoprolol, Hydrochlorothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 171 No known interaction 2,659 (incl. Bisoprolol, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Cannabigerol (cbg)

Covers the 2,830 medications we’ve checked against Cannabigerol (cbg). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Bisoprolol, Hydrochlorothiazide

This page covers Cannabigerol (cbg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bisoprolol, Hydrochlorothiazide page lists 276 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 11 major · 234 moderate · 31 minor.

From our pharmacist’s overview on the Bisoprolol, Hydrochlorothiazide page

“This is one of the supplement lists I would read closely before adding anything alongside bisoprolol and hydrochlorothiazide (Ziac). The combination already lowers blood pressure two ways, and most of these interactions push on those same levers, either dropping pressure further or acting like extra diuretics that compound potassium an…”

Reviewed by 2 · Jul 18, 2026

Open the Bisoprolol, Hydrochlorothiazide interaction page

How much people look this up

Where Cannabigerol (cbg) and Bisoprolol, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabigerol (cbg)
Top half

#623 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bisoprolol, Hydrochlorothiazide
Top half

#755 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cannabigerol (cbg)

What is Cannabigerol (cbg)?

  • Anxiety and stress
  • Pain and inflammation
  • Sleep support
  • Focus and mood
  • Digestive discomfort

Cannabigerol (CBG) is a minor cannabinoid from the cannabis (hemp) plant that is marketed for anxiety, pain, and inflammation, but human research is very limited and most claims rest on laboratory and animal studies. It appears to be generally well tolerated in early reports, but its long-term safety, quality, and dosing are not well established. Talk to your pharmacist or doctor before trying it, especially if you take other medicines or are pregnant or breastfeeding.

Read the full Cannabigerol (cbg) monograph & all interactions
Keep checking

Other Drugs & Cannabigerol (cbg)

Browse every other medication we’ve checked against Cannabigerol (cbg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
171Moderate
0Minor
2,658No known interaction
171 Moderate 2,658 No interaction
Moderate

171 interactions

Showing 60 of 171 moderate interactions — see all 171 on the Cannabigerol (cbg) page.

No interaction 2,658 drugs checked — show the list

We also checked Cannabigerol (cbg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,658 medications checked with no known interaction — see the full Cannabigerol (cbg) list.

See the full Cannabigerol (cbg) interactions page
See every supplement checked against Bisoprolol, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cannabigerol (cbg) monograph › Uses, safety, and every drug interaction in one place Bisoprolol, Hydrochlorothiazide supplement interactions › Every supplement checked against Bisoprolol, Hydrochlorothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cannabigerol (cbg) and Bisoprolol, Hydrochlorothiazide Together: Common Questions

Can you take Cannabigerol (cbg) with Bisoprolol, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cannabigerol (cbg) and Bisoprolol, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bisoprolol, Hydrochlorothiazide and Cannabigerol (cbg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.