Drug & supplement interaction

Chlorophyllin + Norgestrel

Norgestrel brand names: Ovrette, Orval 21.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chlorophyllin and Norgestrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chlorophyllin and Norgestrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Norgestrel and Chlorophyllin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chlorophyllin safety at a glance

Chlorophyllin overall Use caution Generally well tolerated short-term, but quality evidence and long-term safety data are limited.
Pregnancy Avoid Not enough reliable safety data, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoidance is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Norgestrel and Chlorophyllin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Norgestrel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Norgestrel is filed under 5 classifications — including contraceptive drugs, cytochrome p450 1a2 (cyp1a2) inhibitors, hepatotoxic drugs. Chlorophyllin has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Norgestrel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chlorophyllin Does Interact With Other Medications

Chlorophyllin has 335 moderate known drug interactions in our database — Norgestrel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Norgestrel)
Taking anything else?

Check Another of Your Medications Against Chlorophyllin

Covers the 2,830 medications we’ve checked against Chlorophyllin. Pick one to open its full report.

What to actually watch for

What Chlorophyllin Itself Has Been Linked To

This is not an interaction — nothing below involves Norgestrel. It is the side-effect record for Chlorophyllin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chlorophyllin, this list is the first place to look.

  • Sun sensitivity / A skin rash Additional detail

    “Since chlorophyllin is a semi-synthetic derivative of chlorophyll, there is some concern that it could cause similar adverse effects. Topically, chlorophyll cream has been reported to cause dermatitis. Orally, chlorophyll can cause photosensitization. In case reports, oral consumption of chlorophyll has been associated with the development of pseudoporphyria.”

    Chlorophyllin · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 41912. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
    2. 1326. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
    3. 93892. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
    4. 97933. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
    5. 101235. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Chlorophyllin — expand a row for the licensed statement it rests on. We haven’t matched Norgestrel to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Norgestrel.

Everything else you take

See Every Supplement That Interacts With Norgestrel

This page covers Chlorophyllin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Norgestrel page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 140 moderate · 42 minor.

From our pharmacist’s overview on the Norgestrel page

“Norgestrel (Ovrette) is a progestin-only birth control pill, so the biggest danger on this page is not a strange side effect but a pill that quietly stops working. That risk makes this a page for genuine vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the Norgestrel interaction page

One more smart check

Taking Chlorophyllin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 357 real supplement products containing Chlorophyllin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chlorophyllin. Even though Chlorophyllin itself has no known interaction with Norgestrel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chlorophyllin and Norgestrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chlorophyllin
Top half

#507 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Norgestrel
Steady interest

#1,670 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chlorophyllin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chlorophyllin and Norgestrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chlorophyllin

What is Chlorophyllin?

Chlorophyllin
  • Body and breath odor control
  • Wound and skin care
  • Internal deodorant for ostomy or incontinence
  • Detoxification claims
  • Digestive support

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a deodorizing agent, while many popular claims like detoxification and digestive benefits are not well proven. It is generally considered safe for short-term use, but talk to your pharmacist or doctor before starting it, especially during pregnancy or breastfeeding.

Semi-synthetic derivative of chlorophyll (originally from green plant leaves) · Tablets, capsules, liquid drops, topical ointments and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chlorophyllin is a good idea for someone in your situation. Here is what our Chlorophyllin record says about it on its own.

Chlorophyllin: dosing

There is no official standardized dose for chlorophyllin, and the amount used in studies has varied. Products come in different strengths and forms, so the right amount depends on the specific product and how it is being used.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Chlorophyllin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chlorophyllin monograph & all interactions
Medication

About Progestin-Only (norethindrone) Oral Contraceptives

What Is Progestin-Only (norethindrone) Oral Contraceptives Used For?

Brand names: Ovrette, Orval 21

Norethindrone progestin-only pills — sometimes called the "mini-pill" — are used solely to prevent pregnancy. They do not contain estrogen, which makes them an option for women who cannot or prefer not to use estrogen-containing contraceptives.

When taken perfectly (same time every day, no missed pills), fewer than 1 in 100 women will become pregnant in the first year. With typical use, that number rises to about 9 in 100 — mostly because of late or skipped pills. Consistency is everything with this method.

Most-Reported Side Effects for Norgestrel

From FAERS, the FDA’s public side-effect reporting system (2,254 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Heavy menstrual bleeding 247 reports
Pregnancy on oral contraceptive 210 reports
Intermenstrual bleeding 182 reports
Polymenorrhoea 157 reports
Nausea 143 reports
See full Progestin-Only (norethindrone) Oral Contraceptives drug information
Keep checking

Other Drugs & Chlorophyllin

Browse every other medication we’ve checked against Chlorophyllin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Chlorophyllin page.

No interaction 2,494 drugs checked — show the list

We also checked Chlorophyllin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Chlorophyllin list.

See the full Chlorophyllin interactions page
See every supplement checked against Norgestrel, ranked by severity
Evidence & sources

Chlorophyllin References

The 6 references that drive our Chlorophyllin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chlorophyllin and Norgestrel Together: Common Questions

Is it safe to take Chlorophyllin with Norgestrel?
We do not list a known interaction between Chlorophyllin and Norgestrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Chlorophyllin and Norgestrel combination checked?
Interactions in our licensed database are recorded against drug classes. Norgestrel is filed under 5 classifications, and Chlorophyllin has documented interactions with 1 drug class — none of Norgestrel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chlorophyllin interact with any other medications?
Yes. Chlorophyllin has 335 documented drug interactions in our database — Norgestrel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Norgestrel interact with any supplements?
Yes. Norgestrel has documented interactions with 188 supplements in our database — Chlorophyllin is not one of them. The Norgestrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chlorophyllin monograph Uses, safety profile, and every drug interaction in one place Progestin-Only (norethindrone) Oral Contraceptives drug information The full plain-English guide to this medication Norgestrel supplement interactions Every supplement checked against Norgestrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Norgestrel and Chlorophyllin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.