Drug & supplement interaction

Damiana + Ruxolitinib

Ruxolitinib brand names: Jakafi, Opzelura.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Damiana and Ruxolitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Damiana and Ruxolitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ruxolitinib and Damiana in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Damiana safety at a glance

Damiana overall Use caution Likely fine in food/tea amounts for most adults, but human safety data are limited.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ruxolitinib and Damiana? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ruxolitinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ruxolitinib is filed under 3 classifications — topical drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Damiana has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Ruxolitinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Damiana Does Interact With Other Medications

Damiana has 86 moderate known drug interactions in our database — Ruxolitinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Ruxolitinib)
Taking anything else?

Check Another of Your Medications Against Damiana

Covers the 2,830 medications we’ve checked against Damiana. Pick one to open its full report.

What to actually watch for

What Damiana Itself Has Been Linked To

This is not an interaction — nothing below involves Ruxolitinib. It is the side-effect record for Damiana on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Damiana, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    “Orally, 200 grams of damiana extract has caused tetanus-like convulsions and paroxysms resulting in symptoms similar to rabies or strychnine poisoning (4).”

    Damiana · Natural Medicines adverse-effect record, reported in poisoning.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Damiana — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ruxolitinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ruxolitinib column appears here.

Everything else you take

See Every Supplement That Interacts With Ruxolitinib

This page covers Damiana only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ruxolitinib page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Ruxolitinib page

“Ruxolitinib (Jakafi for myelofibrosis and other blood cancers, Opzelura as a skin cream) is cleared by one liver enzyme, CYP3A4, and that single fact explains nearly all 141 supplements here, which is why this list deserves real caution. Three entries are rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Ruxolitinib interaction page

One more smart check

Taking Damiana as Part of a Dietary Supplement Product? Check It for Interactions

We hold 881 real supplement products containing Damiana, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Damiana. Even though Damiana itself has no known interaction with Ruxolitinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Damiana and Ruxolitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Damiana
Top 25%

#208 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ruxolitinib
Top 25%

#361 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Damiana reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Damiana and Ruxolitinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Damiana

What is Damiana?

Damiana
  • Low libido / aphrodisiac
  • Anxiety and stress
  • Mood and mild low energy
  • Digestive upset
  • Headache and general tonic

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small amounts found in teas, but quality studies are lacking, so talk with your pharmacist or doctor before using it—especially if you are pregnant, breastfeeding, or have a health condition.

Turnera diffusa · Passifloraceae · Leaves (and sometimes stems) · Tea, capsules, tinctures, liquid extracts, dried leaf

An interaction check asks whether these two react with each other — it does not ask whether Damiana is a good idea for someone in your situation. Here is what our Damiana record says about it on its own.

Damiana: dosing

There is no well-established standard dose for damiana. The amount people use varies widely depending on the form—tea, capsule, or tincture.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because strength differs from product to product, a pharmacist can help you decide whether a particular product and dose make sense for you.If you try damiana, start low, watch how you feel, and stop if you notice side effects.

From our Damiana monograph — the full record covers uses, side effects and every documented interaction.

Read the full Damiana monograph & all interactions
Medication

About Ruxolitinib

What Is Ruxolitinib Used For?

Brand names: Jakafi, Opzelura

Ruxolitinib is approved to treat several serious blood and immune conditions in adults, and some in patients as young as 12. It is used for myelofibrosis (a bone marrow disorder that disrupts normal blood cell production), polycythemia vera (a condition where the bone marrow makes too many red blood cells), and two forms of graft-versus-host disease (GVHD) — a complication that can occur after a stem cell transplant.

For polycythemia vera, it is specifically for patients who have not responded well to, or cannot tolerate, a medication called hydroxyurea. For chronic GVHD, it is used after at least one or two other treatments have failed.

Most-Reported Side Effects for Ruxolitinib

From FAERS, the FDA’s public side-effect reporting system (71,241 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 6,114 reports
Anemia 3,094 reports
Haemoglobin decreased 2,961 reports
Platelet count decreased 2,700 reports
Diarrhea 2,683 reports
See full Ruxolitinib drug information
Keep checking

Other Drugs & Damiana

Browse every other medication we’ve checked against Damiana — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Damiana page.

No interaction 2,743 drugs checked — show the list

We also checked Damiana against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Damiana list.

See the full Damiana interactions page
See every supplement checked against Ruxolitinib, ranked by severity
Evidence & sources

Damiana References

The 2 references that drive our Damiana monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Alarcon-Aquilar FJ, Roman-Ramos R, Perez-Gutierrez S, et al. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Damiana and Ruxolitinib Together: Common Questions

Is it safe to take Damiana with Ruxolitinib?
We do not list a known interaction between Damiana and Ruxolitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Damiana and Ruxolitinib combination checked?
Interactions in our licensed database are recorded against drug classes. Ruxolitinib is filed under 3 classifications, and Damiana has documented interactions with 1 drug class — none of Ruxolitinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Damiana interact with any other medications?
Yes. Damiana has 86 documented drug interactions in our database — Ruxolitinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ruxolitinib interact with any supplements?
Yes. Ruxolitinib has documented interactions with 141 supplements in our database — Damiana is not one of them. The Ruxolitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Damiana monograph Uses, safety profile, and every drug interaction in one place Ruxolitinib drug information The full plain-English guide to this medication Ruxolitinib supplement interactions Every supplement checked against Ruxolitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ruxolitinib and Damiana?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.