Datura Wrightii - Chlorpheniramine, Hydrocodone, Pseudoephedrine Interaction Details

Interaction Details

Chlorpheniramine, Hydrocodone, Pseudoephedrine is classified as belonging to the following category: Anticholinergic Drugs

Datura wrightii contains atropine and scopolamine, as well as other tropane alkaloids with anticholinergic activity. Concomitant use of Datura wrightii with anticholinergic drugs might increase anticholinergic effects and adverse effects. Some anticholinergic drugs include amantadine, atropine, belladonna alkaloids, phenothiazines, scopolamine, and tricyclic antidepressants.

Interaction Rating

Moderate

Likelihood of Occurrence

Probable

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

Adams, JD Jr, Garcia C. Spirit, Mind and Body in Chumash Healing. Evid Based Complement Alternat Med 2005;2(4):459-463.
Evans WC, Woolley JG. The alkaloids of Datura meteloides D.C. J Chem Soc Perkin 1. 1965;4936-4939.

Datura Wrightii - More Interactions

Datura Wrightii interacts with 224 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.