Drug & supplement interaction

Evening Primrose + Ombitasvir, Paritaprevir Ritonavir

Ombitasvir, Paritaprevir Ritonavir brand name: Technivie.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Evening Primrose has a moderate interaction with Ombitasvir, Paritaprevir Ritonavir. Theoretically, evening primrose oil might increase the levels and effects of lopinavir.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Evening Primrose and Ombitasvir, Paritaprevir Ritonavir

Here is the interaction we found between these two, with the evidence behind it.

Moderate

LOPINAVIR/RITONAVIR (Kaletra)

Theoretically, evening primrose oil might increase the levels and effects of lopinavir.
In a case report, an HIV patient who took evening primrose oil (Efamol) along with lopinavir/ritonavir experienced an increase in serum levels of lopinavir to 15.2 mg/L. Six weeks after discontinuing evening primrose oil, levels of lopinavir returned to the normal range of 5-10 mg/L. When re-challenged with evening primrose oil for a week, the patient's lopinavir levels increased from 6.69 to 8.11 mg/L. It is suspected that evening primrose oil increases levels of lopinavir by inhibiting cytochrome P450 3A4 (CYP3A4), which metabolizes lopinavir. However, this effect has not been reported in other research.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Technivie (ombitasvir, paritaprevir, and ritonavir). Part of how this combo works is that the ritonavir piece is a strong helper that slows down a liver enzyme called CYP3A4, which keeps your drug levels up on purpose. There's a single case report where evening primrose oil seemed to nudge a similar medication (lopinavir/ritonavir) a bit higher, possibly by also slowing that same enzyme. The thought is your Technivie levels could creep up too, which might mean more side effects like nausea, tiredness, itching, or trouble sleeping.

Honestly, this is weak, theoretical evidence (one patient), so I wouldn't lose sleep over it. Still, since these meds are already finely balanced, it's worth a quick chat with your pharmacist or doctor before adding evening primrose. Don't change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Evening Primrose Also Interacts With Other Medications

Evening Primrose has 147 moderate, 86 minor known drug interactions in our database — the Ombitasvir, Paritaprevir Ritonavir one above is one of them. If you take anything else, check it against the full list below.

Moderate 147 Minor 86 No known interaction 2,597 (incl. Ombitasvir, Paritaprevir Ritonavir)
Taking anything else?

Check Another of Your Medications Against Evening Primrose

Covers the 2,830 medications we’ve checked against Evening Primrose. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ombitasvir, Paritaprevir Ritonavir

This page covers Evening Primrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ombitasvir, Paritaprevir Ritonavir page lists 154 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,4-butanediol (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 113 moderate · 38 minor.

From our pharmacist’s overview on the Ombitasvir, Paritaprevir Ritonavir page

“Technivie (ombitasvir, paritaprevir, and ritonavir) treats hepatitis C, and because a cure depends on holding steady drug levels for the whole course, this list warrants genuine care. Most of the 154 ingredients on file touch the CYP3A4 enzyme pathway, meaning they can push the drug's blood levels up or down.”

Reviewed by 2 · Jul 18, 2026

Open the Ombitasvir, Paritaprevir Ritonavir interaction page

One more smart check

Taking Evening Primrose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 98 real supplement products containing Evening Primrose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Evening Primrose. Your product may carry other ingredients that interact with Ombitasvir, Paritaprevir Ritonavir too, on top of Evening Primrose — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Evening Primrose and Ombitasvir, Paritaprevir Ritonavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Evening Primrose
Top half

#483 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ombitasvir, Paritaprevir Ritonavir
Top 5%

#78 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Evening Primrose

What is Evening Primrose?

Evening Primrose
  • Eczema and skin health
  • PMS symptoms
  • Breast pain (mastalgia)
  • Menopause symptoms
  • Inflammation
  • Diabetic nerve pain

Evening primrose oil is a seed oil rich in gamma-linolenic acid (GLA), an omega-6 fatty acid, that is popularly used for skin conditions, PMS, and breast pain. The evidence behind most of these uses is mixed or weak, and it is not proven to be a reliable treatment for any condition. It is generally well tolerated for short-term use, but talk to your pharmacist or doctor before starting it, especially if you are pregnant or have a bleeding disorder.

Read the full Evening Primrose monograph & all interactions
Medication

About Ombitasvir, Paritaprevir, and Ritonavir

What Is Ombitasvir, Paritaprevir, and Ritonavir Used For?

Brand name: Technivie

  • The combination of ombitasvir, paritaprevir, and ritonavir is usually used in combination with ribavirin (Copegus, Rebetol), but sometimes it is used alone to treat a certain type of chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect. It is not known if ombitasvir, paritaprevir, or ritonavir prevent the spread of hepatitis C to other people.

See full Ombitasvir, Paritaprevir, and Ritonavir drug information
Keep checking

Other Drugs & Evening Primrose

Browse every other medication we’ve checked against Evening Primrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
147Moderate
86Minor
2,596No known interaction
147 Moderate 86 Minor 2,596 No interaction
Moderate

147 interactions

Showing 60 of 147 moderate interactions — see all 147 on the Evening Primrose page.

Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Evening Primrose page.

No interaction 2,596 drugs checked — show the list

We also checked Evening Primrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,596 medications checked with no known interaction — see the full Evening Primrose list.

See the full Evening Primrose interactions page
See every supplement checked against Ombitasvir, Paritaprevir Ritonavir, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Evening Primrose monograph › Uses, safety, and every drug interaction in one place Ombitasvir, Paritaprevir Ritonavir supplement interactions › Every supplement checked against Ombitasvir, Paritaprevir Ritonavir, ranked by severity Ombitasvir, Paritaprevir, and Ritonavir drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Evening Primrose and Ombitasvir, Paritaprevir Ritonavir Together: Common Questions

Can you take Evening Primrose with Ombitasvir, Paritaprevir Ritonavir?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Evening Primrose and Ombitasvir, Paritaprevir Ritonavir interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ombitasvir, Paritaprevir Ritonavir and Evening Primrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.