Drug & supplement interaction

Goji + Levothyroxine Sodium

Levothyroxine Sodium brand names: Tirosint-Sol, Thyquidity, Ermez.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Goji and Levothyroxine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Levothyroxine Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Goji and Levothyroxine Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levothyroxine Sodium and Goji in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goji safety at a glance

Goji overall Use caution Generally safe as a food, but concentrated supplements have less safety data.

Pregnancy Avoid Avoid medicinal amounts during pregnancy due to limited safety data and traditional reports of uterine effects.

Breastfeeding Use caution Not enough reliable data on supplement use while breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levothyroxine Sodium and Goji? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Levothyroxine Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levothyroxine Sodium is filed under 3 classifications — including thyroid hormone, oral drugs. Goji has documented interactions with 8 drug classes — the most serious being warfarin (coumadin) (major), antihypertensive drugs (moderate) and cytochrome p450 2c19 (cyp2c19) substrates (moderate) — and none of Levothyroxine Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Goji Does Interact With Other Medications

Goji has 2 major, 930 moderate, 68 minor known drug interactions in our database — Levothyroxine Sodium isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 930 Minor 68 No known interaction 1,830 (incl. Levothyroxine Sodium)

Taking anything else?

Check Another of Your Medications Against Goji

Covers the 2,830 medications we’ve checked against Goji. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Goji and Levothyroxine Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

Shortness of breath / A severe allergic reaction / An allergic reaction Worth acting on reported in 5.3% of FDA reports for Levothyroxine Sodium Additional detail
Goji
“Several cases of allergic reactions secondary to consumption of goji berries have been reported. Symptoms included facial angioedema with dyspnea, pharyngeal itching, itching in the mouth, ears, and axilla, labial angioedema, and perioral skin rash. Anaphylaxis has also been reported.”

Goji · Natural Medicines adverse-effect record, reported in pruritus.
2 sources cited

92116. Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.

52538. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
Levothyroxine Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Itching / A skin rash Additional detail

Goji

Recorded for Goji in the same Natural Medicines adverse-effect record shown under Shortness of breath / A severe allergic reaction / An allergic reaction above.

Levothyroxine Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium. Read the label on DailyMed ›

Reported for Goji but not commonly for Levothyroxine Sodium: liver problems.

Effects for Levothyroxine Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Goji come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 312,551 voluntary FDA FAERS reports for Levothyroxine Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Levothyroxine Sodium Products Have a Food Rule — Goji Should Not Break It

At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach. Most supplements — Goji included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine Sodium on its own and move Goji to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Levothyroxine Sodium

This page covers Goji only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine Sodium page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

Open the Levothyroxine Sodium interaction page

One more smart check

Taking Goji as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,738 real supplement products containing Goji, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goji. Even though Goji itself has no known interaction with Levothyroxine Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goji and Levothyroxine Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goji

Top 10%

#145 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Levothyroxine Sodium

Top 5%

#132 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goji reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Goji and Levothyroxine Sodium records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Goji

What is Goji?

General antioxidant support
Eye health
Immune support
Anti-aging and well-being
Blood sugar support

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune support, and general wellness, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated goji supplements, especially if you take medications or are pregnant.

Lycium barbarum · Solanaceae · Fruit (berries); root bark and leaves are also used in traditional medicine · Dried berries, juice, capsules, powders, teas, extracts

An interaction check asks whether these two react with each other — it does not ask whether Goji is a good idea for someone in your situation. Here is what our Goji record says about it on its own.

Goji: dosing

There is no official or proven standard dose for goji. Amounts used in studies and products vary widely depending on whether you use dried berries, juice, or an extract.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you choose a reputable product and make sure it fits with your other medicines and health conditions.

From our Goji monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goji monograph & all interactions

Medication

About Levothyroxine Sodium

Most-Reported Side Effects for Levothyroxine Sodium

From FAERS, the FDA’s public side-effect reporting system (312,551 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 26,585 reports

Nausea 22,605 reports

Headache 19,408 reports

Diarrhea 18,759 reports

Dyspnea 16,717 reports

Keep checking

Other Drugs & Goji

Browse every other medication we’ve checked against Goji — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major

930Moderate

68Minor

1,829No known interaction

2 Major 930 Moderate 68 Minor 1,829 No interaction

Major

2 interactions

Moderate

930 interactions

Showing 60 of 930 moderate interactions — see all 930 on the Goji page.

Minor

68 interactions

Showing 60 of 68 minor interactions — see all 68 on the Goji page.

No interaction 1,829 drugs checked — show the list

We also checked Goji against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,829 medications checked with no known interaction — see the full Goji list.

See the full Goji interactions page

See every supplement checked against Levothyroxine Sodium, ranked by severity

Evidence & sources

Goji References

The 14 references that drive our Goji monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
Zhang J, Tian L, Xie B. Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.). Toxicol Rep. 2015;2:1209-1212. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goji and Levothyroxine Sodium Together: Common Questions

Is it safe to take Goji with Levothyroxine Sodium?

We do not list a known interaction between Goji and Levothyroxine Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Goji and Levothyroxine Sodium have any of the same side effects?

Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Goji and Levothyroxine Sodium at the same time of day?

At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Levothyroxine Sodium on its own and move Goji to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Goji and Levothyroxine Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Levothyroxine Sodium is filed under 3 classifications, and Goji has documented interactions with 8 drug classes — none of Levothyroxine Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Goji interact with any other medications?

Yes. Goji has 1,000 documented drug interactions in our database — Levothyroxine Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Levothyroxine Sodium interact with any supplements?

Yes. Levothyroxine Sodium has documented interactions with 50 supplements in our database — Goji is not one of them. The Levothyroxine Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Goji monograph Uses, safety profile, and every drug interaction in one place Levothyroxine Sodium supplement interactions Every supplement checked against Levothyroxine Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levothyroxine Sodium and Goji?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.