Drug & supplement interaction

Goji + Trimipramine

Trimipramine brand names: Surmontil, Trimip, Rhotrimine, Tripramine, Trimp.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Goji has a moderate interaction with Trimipramine. Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Goji and Trimipramine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

Why this applies to Trimipramine

Trimipramine falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES — the group Goji interacts with.

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for trimipramine (Surmontil). Your liver uses an enzyme called CYP2C9 to help break this antidepressant down. Goji berry, in concentrated forms like strong teas, juices, or supplement extracts, may slow that same enzyme. If it does, your body could clear trimipramine more slowly, letting levels creep up.

What that might feel like is more of trimipramine's usual side effects: drowsiness, dry mouth, constipation, blurred vision, dizziness when standing, or a faster heartbeat. Keep in mind this is mostly theoretical, based on lab studies and a few warfarin reports, not solid human data on trimipramine. Eating a few goji berries as food is unlikely to matter. Before adding a concentrated goji product, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
  2. Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
  3. Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Goji Also Interacts With Other Medications

Goji has 2 major, 929 moderate, 68 minor known drug interactions in our database — the Trimipramine one above is one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 929 Minor 68 No known interaction 1,831 (incl. Trimipramine)
Taking anything else?

Check Another of Your Medications Against Goji

Covers the 2,830 medications we’ve checked against Goji. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Trimipramine

This page covers Goji only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trimipramine page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 100 moderate · 30 minor.

From our pharmacist’s overview on the Trimipramine page

“If you take trimipramine (Surmontil), a tricyclic antidepressant, read this list carefully. Nine of the 139 supplements and herbs on file are rated major, and most touch the heart: several, grapefruit among them, can stretch the QT interval, the heart's electrical reset time, and raise the risk of a dangerous rhythm.”

Reviewed by 2 · Jul 18, 2026

Open the Trimipramine interaction page

One more smart check

Taking Goji as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,738 real supplement products containing Goji, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goji. Your product may carry other ingredients that interact with Trimipramine too, on top of Goji — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goji and Trimipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goji
Top 10%

#145 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trimipramine
Top half

#1,331 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Goji

What is Goji?

Goji
  • General antioxidant support
  • Eye health
  • Immune support
  • Anti-aging and well-being
  • Blood sugar support

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune support, and general wellness, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated goji supplements, especially if you take medications or are pregnant.

Read the full Goji monograph & all interactions
Medication

About Trimipramine

What Is Trimipramine Used For?

Brand names: Surmontil, Trimip, Rhotrimine, Tripramine, Trimp

Trimipramine capsules are indicated for the relief of symptoms of depression. Endogenous depression — depression that arises from within, rather than from an obvious outside cause — is more likely to respond to treatment than other types.

In clinical studies, trimipramine worked as well as imipramine in hospitalized patients with depression, and was comparable to amitriptyline in less severely depressed outpatients.

See full Trimipramine drug information
Keep checking

Other Drugs & Goji

Browse every other medication we’ve checked against Goji — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
929Moderate
68Minor
1,830No known interaction
2 Major 929 Moderate 68 Minor 1,830 No interaction
Major

2 interactions

Moderate

929 interactions

Showing 60 of 929 moderate interactions — see all 929 on the Goji page.

Minor

68 interactions

Showing 60 of 68 minor interactions — see all 68 on the Goji page.

No interaction 1,830 drugs checked — show the list

We also checked Goji against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,830 medications checked with no known interaction — see the full Goji list.

See the full Goji interactions page
See every supplement checked against Trimipramine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Goji monograph › Uses, safety, and every drug interaction in one place Trimipramine supplement interactions › Every supplement checked against Trimipramine, ranked by severity Trimipramine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Goji and Trimipramine Together: Common Questions

Can you take Goji with Trimipramine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Goji and Trimipramine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Trimipramine and Goji?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.