Drug & supplement interaction

Jiaogulan + Salmeterol

Salmeterol brand name: Serevent.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jiaogulan and Salmeterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Salmeterol states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Jiaogulan and Salmeterol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Salmeterol and Jiaogulan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jiaogulan safety at a glance

Jiaogulan overall Use caution Generally well tolerated in tea or supplement form for short periods, but long-term safety is not well studied.
Pregnancy Possibly Unsafe When used orally. Ginsenoside Rb1, which is identical to the jiaogulan constituent gypenoside 3, has teratogenic effects in animal models; avoid using. Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding because there is not enough safety information.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Salmeterol and Jiaogulan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Salmeterol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Salmeterol is filed under 3 classifications — beta-adrenergic agonists, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates. Jiaogulan has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Salmeterol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jiaogulan Does Interact With Other Medications

Jiaogulan has 327 moderate known drug interactions in our database — Salmeterol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Salmeterol)
Taking anything else?

Check Another of Your Medications Against Jiaogulan

Covers the 2,830 medications we’ve checked against Jiaogulan. Pick one to open its full report.

What to actually watch for

What Jiaogulan Itself Has Been Linked To

This is not an interaction — nothing below involves Salmeterol. It is the side-effect record for Jiaogulan on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Jiaogulan, this list is the first place to look.

  • Dry mouth Additional detail

    “Orally, jiaogulan may cause diarrhea and nausea (6,106651). Dry mouth has also been reported with oral jiaogulan use.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 106651. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.
  • Trouble sleeping / Dizziness Additional detail

    “Orally, jiaogulan may cause dizziness and insomnia.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 106651. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.
  • Diarrhea / Nausea Additional detail

    “Orally, jiaogulan seems to be well tolerated when used for up to 4 months.

    Most Common Adverse Effects:

    Orally: Diarrhea and nausea.”

    Jiaogulan · Natural Medicines adverse-effect record, reported in diarrhea.

Everything above comes from the Natural Medicines adverse-effect record for Jiaogulan — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Salmeterol’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Salmeterol column appears here.

Special populations

Jiaogulan in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Ginsenoside Rb1, which is identical to the jiaogulan constituent gypenoside 3, has teratogenic effects in animal models; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Salmeterol Products Have a Food Rule — Jiaogulan Should Not Break It

At least one FDA label for a product containing Salmeterol says to take it on an empty stomach. Most supplements — Jiaogulan included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Salmeterol on its own and move Jiaogulan to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Salmeterol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

One inhalation of SEREVENT DISKUS at least 30 minutes before exercise has been shown to protect patients against EIB.

From the Dosage and Administration section of the FDA label we read for Salmeterol — where that label names a specific product, the instruction is that product's. See the Salmeterol drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Salmeterol

This page covers Jiaogulan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Salmeterol page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 7 major · 105 moderate · 29 minor.

From our pharmacist’s overview on the Salmeterol page

“Salmeterol (Serevent) is the long-acting inhaler taken twice daily for asthma or COPD, and its supplement list is one I would approach with real caution. Seven of the 141 ingredients on file rate major: grapefruit can raise salmeterol levels by blocking the enzyme that clears it, St.”

Reviewed by 2 · Jul 18, 2026

Open the Salmeterol interaction page

One more smart check

Taking Jiaogulan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 452 real supplement products containing Jiaogulan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jiaogulan. Even though Jiaogulan itself has no known interaction with Salmeterol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jiaogulan and Salmeterol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jiaogulan
Top 25%

#330 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Salmeterol
Steady interest

#2,546 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jiaogulan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jiaogulan and Salmeterol records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jiaogulan

What is Jiaogulan?

Jiaogulan
  • Fatigue and stress (adaptogen)
  • Blood sugar support
  • High blood pressure
  • High cholesterol
  • Immune and general wellness

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some uses like metabolism and blood pressure, but the overall evidence is still limited. Talk with your pharmacist or doctor before starting it, especially if you have a health condition or take medication.

Gynostemma pentaphyllum · Cucurbitaceae · Leaves and aerial parts · Tea, capsules, tablets, liquid extracts, powders

An interaction check asks whether these two react with each other — it does not ask whether Jiaogulan is a good idea for someone in your situation. Here is what our Jiaogulan record says about it on its own.

Jiaogulan: dosing

There is no official, standardized dose of jiaogulan. The right amount can vary depending on the product, its strength, and whether it is a tea, capsule, or extract.The safest approach is to follow the directions on the product label and not to exceed the recommended amount.

From our Jiaogulan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jiaogulan monograph & all interactions
Medication

About Salmeterol Oral Inhalation

What Is Salmeterol Oral Inhalation Used For?

Brand name: Serevent

Serevent Diskus (salmeterol inhalation powder) is used for three main purposes: treating asthma in patients aged 4 and older alongside an inhaled corticosteroid (ICS), preventing exercise-induced bronchospasm (EIB) in patients aged 4 and older, and providing long-term maintenance treatment of bronchospasm associated with COPD — including chronic bronchitis and emphysema — in adults.

Important: Serevent Diskus is not a rescue inhaler. It will not relieve a sudden asthma or COPD attack. For asthma, it must always be used together with an inhaled corticosteroid — using it alone for asthma is contraindicated due to a serious risk of asthma-related death.

See full Salmeterol Oral Inhalation drug information
Keep checking

Other Drugs & Jiaogulan

Browse every other medication we’ve checked against Jiaogulan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Jiaogulan page.

No interaction 2,502 drugs checked — show the list

We also checked Jiaogulan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Jiaogulan list.

See the full Jiaogulan interactions page
See every supplement checked against Salmeterol, ranked by severity
Evidence & sources

Jiaogulan References

The 8 references that drive our Jiaogulan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jiaogulan and Salmeterol Together: Common Questions

Is it safe to take Jiaogulan with Salmeterol?
We do not list a known interaction between Jiaogulan and Salmeterol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Jiaogulan and Salmeterol at the same time of day?
At least one FDA label for a product containing Salmeterol says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Salmeterol on its own and move Jiaogulan to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Jiaogulan and Salmeterol combination checked?
Interactions in our licensed database are recorded against drug classes. Salmeterol is filed under 3 classifications, and Jiaogulan has documented interactions with 3 drug classes — none of Salmeterol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jiaogulan interact with any other medications?
Yes. Jiaogulan has 327 documented drug interactions in our database — Salmeterol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Salmeterol interact with any supplements?
Yes. Salmeterol has documented interactions with 141 supplements in our database — Jiaogulan is not one of them. The Salmeterol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jiaogulan monograph Uses, safety profile, and every drug interaction in one place Salmeterol Oral Inhalation drug information The full plain-English guide to this medication Salmeterol supplement interactions Every supplement checked against Salmeterol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Salmeterol and Jiaogulan?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.