Passion Flower - Xywav (Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate) Interaction
Herbal: Passion Flower
Also Known As: Passiflora incarnata, Apricot Vine, Burucuya, Granadilla, Grandilla, Maracuja, Maracuya, Maypop, Pasiflora, Pasionari, Pasionaria, Passiflora, Passiflore, Passiflorina, Passion Vine, Passionaria, Passionblume, Passionflower, Passionflower Herb, Passionsblomma, Water Lemon
Drug: Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
Brand names:
Xywav
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Passion Flower. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Passionflower is not known to have many clinically significant drug interactions.
Nevertheless, it has been shown to have sedative effects, which can be additive when used in conjunction with sedative medications (e.g., Benadryl, benzodiazepines, opioids, etc...).
Therefore, we do list interactions between Passionflower and CNS (central nervous system) depressants or other drugs with strong sedative effects.
Additionally, certain constituents of Passionflower (such as apigenin and vitexin) may inhibit certain drug transports, specifically OATP2B1 and OATP1A2.
These are responsible for the uptake of certain drugs and other compounds into the body.
As Passionflower can inhibit these transports, it is possible that it might reduce the bioavailability of drugs that are substrates for these transporters but studies are far from conclusive on the matter.
There is no known drug interaction between Passionflower and the drug in question here, however.
As always, be sure to speak with your doctor before making any changes to your medication regimen.
- Dr. Brian Staiger, PharmDPassion Flower Overview
Passionflower (Passiflora incarnata) is a climbing vine with fragrant white and purple flowers that is native to the Americas.
It is purported to have a number of potential health benefits, including reducing anxiety and improving sleep. It is thought to work by increasing the levels of GABA (gamma-aminobutyric acid), a neurotransmitter in the brain that helps regulate mood and anxiety. Passionflower may also have mild sedative and muscle-relaxing effects and may be helpful in the treatment of muscle spasms and other muscle disorders.
Dietary supplements containing passionflower are generally standardized to contain no less than 1.5% of the flavanoid vitexin.
Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Overview
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Calcium, magnesium, potassium, and sodium oxybate is used to treat attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) and excessive daytime sleepiness in adults and children 7 years of age and older who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudden uncontrollable urge to sleep during daily activities, and cataplexy). Calcium, magnesium, potassium, and sodium oxybate is also used to treat adults who have idiopathic hypersomnia (IH; a sleep disorder that may cause excessive daytime sleepiness and uncontrollable urge to sleep during daily activities despite adequate or prolonged nighttime sleep). Calcium, magnesium, potassium, and sodium oxybate is in a class of medications called central nervous system depressants. Calcium, magnesium, potassium, and sodium oxybate works to treat narcolepsy, cataplexy, and idiopathic hypersomnia by reducing activity in the brain.
Passion Flower - More Interactions
Passion Flower interacts with 814 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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