Turmeric + Cyproterone Acetate, Ethinyl Estradiol
Cyproterone Acetate, Ethinyl Estradiol brand names: Diane-35, Dianette.
Cyproterone Acetate, Ethinyl Estradiol falls into 4 drug categories that Turmeric can interact with; the most serious is rated moderate. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full interaction reportTurmeric and Cyproterone Acetate, Ethinyl Estradiol
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Turmeric interacts with whole categories of medication. Cyproterone Acetate, Ethinyl Estradiol falls into 4 of those categories, so it can interact with Turmeric in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
1 of 4Why this applies to Cyproterone Acetate, Ethinyl Estradiol
Cyproterone Acetate, Ethinyl Estradiol falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Turmeric interacts with.
In vitro and animal research show that turmeric and its constituents curcumin and curcuminoids inhibit CYP3A4. Also, 8 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking turmeric and cancer medications that are CYP3A4 substrates, including everolimus, ruxolitinib, ibrutinib, and palbociclib, and bortezomib. In another case report, a transplant patient presented with acute nephrotoxicity and elevated tacrolimus levels after consuming turmeric powder at a dose of 15 or more spoonfuls daily for ten days prior. It was thought that turmeric increased levels of tacrolimus due to CYP3A4 inhibition.
Conversely, other in vitro research suggests that turmeric induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. An animal model suggests that induction of CYP3A4 occurs after daily curcumin use for 1 week. However, the induction of CYP3A4 by turmeric has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Both the cyproterone and the ethinyl estradiol in Diane-35 are processed by a liver enzyme called CYP3A4. Turmeric, mainly its curcumin compounds, may nudge that enzyme in either direction. The honest answer is that the evidence here is weak, coming mostly from lab dishes and animal studies, not from people taking birth control pills.
If turmeric slowed this enzyme, hormone levels could edge up, which might mean more nausea, breast tenderness, or mood changes. If it sped the enzyme up instead, levels could dip slightly. The amount of turmeric you sprinkle on food almost certainly won't matter. Concentrated curcumin capsules are the bigger question mark, so check with your pharmacist or doctor before adding them.
- Appiah-Opong, R., Commandeur, J. N., Vugt-Lussenburg, B., and Vermeulen, N. P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 6-3-2007;235(1-2):83-91. PubMed
- Hou, X. L., Takahashi, K., Kinoshita, N., Qiu, F., Tanaka, K., Komatsu, K., Takahashi, K., and Azuma, J. Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. Int.J Pharm 6-7-2007;337(1-2):169-177.
- Valentine, S. P., Le Nedelec, M. J., Menzies, A. R., Scandlyn, M. J., Goodin, M. G., and Rosengren, R. J. Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse. Life Sci. 4-11-2006;78(20):2391-2398. PubMed
- Nayeri A, Wu S, Adams E, et al. Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. Transplant Proc. 2017;49(1):198-200. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Pochet S, Lechon AS, Lescrainier C, et al. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Sci Rep 2022;12(1):14178. PubMed
- Dibaei M, Hosseini A, Lavasani H, Kiani-Dehkordi B, Rouini M. Assessment of metabolic interaction between curcumin and tramadol using the isolated perfused rat liver. Heliyon 2024;10(15):e35070. PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
2 of 4Cyproterone Acetate, Ethinyl Estradiol also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
In vitro and animal research show that the turmeric constituent, curcumin, inhibits CYP1A2. However, other in vitro research suggests that curcumin does not significantly affect CYP1A2.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for your Diane-35 (cyproterone acetate plus ethinyl estradiol). In some lab and animal studies, the curcumin in turmeric seems to slow down a liver enzyme called CYP1A2, which is one of the enzymes that helps clear ethinyl estradiol. If that enzyme runs slower, the estrogen part could theoretically build up a bit, which might mean more of the usual estrogen-related effects like nausea, breast tenderness, bloating, or headaches.
I want to be honest with you though: this is only a theoretical concern, the research actually conflicts, and it's rated as minor. The turmeric you use in cooking is very unlikely to do anything here. If you take concentrated curcumin capsules daily, just mention it to your pharmacist or doctor so they can keep an eye on things.
- Thapliyal R, Deshpande SS, Maru GB. Mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived DNA adducts. Cancer Lett 2002;175:79-88. PubMed
- Appiah-Opong, R., Commandeur, J. N., Vugt-Lussenburg, B., and Vermeulen, N. P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 6-3-2007;235(1-2):83-91. PubMed
- Price, R. J., Scott, M. P., Giddings, A. M., Walters, D. G., Stierum, R. H., Meredith, C., and Lake, B. G. Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica 2 PubMed
- Oetari, S., Sudibyo, M., Commandeur, J. N., Samhoedi, R., and Vermeulen, N. P. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol 1-12-1996;51(1):39-45. PubMed
P-GLYCOPROTEIN SUBSTRATES
3 of 4Cyproterone Acetate, Ethinyl Estradiol also falls under P-GLYCOPROTEIN SUBSTRATES.
In vitro and animal research shows that curcuminoids and other constituents found in turmeric can inhibit P-glycoprotein expression and activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Diane-35 (cyproterone with ethinyl estradiol) and turmeric. This combo pill is partly handled by a cellular pump called P-glycoprotein, which helps move drugs in and out of cells. Lab and animal studies hint that the curcumin in turmeric can slow that pump down, which could let a little more of the medication get absorbed. In theory, that might mean slightly stronger hormone exposure, with effects like nausea, breast tenderness, headaches, or mood changes.
That said, this is theoretical and based only on test-tube and animal work, so it's rated minor. Turmeric in your cooking is very unlikely to matter. If you take concentrated curcumin supplements regularly, just mention it to your pharmacist or doctor so they can keep an eye on things.
- Junyaprasert, V. B., Soonthornchareonnon, N., Thongpraditchote, S., Murakami, T., and Takano, M. Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux. Phytother.Res 2006;20(1):79-81. PubMed
- Ampasavate, C., Sotanaphun, U., Phattanawasin, P., and Piyapolrungroj, N. Effects of Curcuma spp. on P-glycoprotein function. Phytomedicine. 2010;17(7):506-512. PubMed
- Hou, X. L., Takahashi, K., Tanaka, K., Tougou, K., Qiu, F., Komatsu, K., Takahashi, K., and Azuma, J. Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways. Int.J Pharm 6-24-2008;358(1-2):224-2 PubMed
- Choi, B. H., Kim, C. G., Lim, Y., Shin, S. Y., and Lee, Y. H. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 1-18-2008;259(1):111-118.
- Zhang, W., Tan, T. M., and Lim, L. Y. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Drug Metab Dispos. 2007;35(1):110-115. PubMed
- Limtrakul, P., Chearwae, W., Shukla, S., Phisalphong, C., and Ambudkar, S. V. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocu
- Holland, M. L., Panetta, J. A., Hoskins, J. M., Bebawy, M., Roufogalis, B. D., Allen, J. D., and Arnold, J. C. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem.Pharmacol 4-14-2006;71(8):1146-1154 PubMed
- Tang, X. Q., Bi, H., Feng, J. Q., and Cao, J. G. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol Sin. 2005;26(8):1009-1016. PubMed
- Nabekura, T., Kamiyama, S., and Kitagawa, S. Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem.Biophys.Res Commun. 2-18-2005;327(3):866-870. PubMed
- Romiti, N., Tongiani, R., Cervelli, F., and Chieli, E. Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes. Life Sci. 1998;62(25):2349-2358. PubMed
- Yue, G. G., Cheng, S. W., Yu, H., Xu, Z. S., Lee, J. K., Hon, P. M., Lee, M. Y., Kennelly, E. J., Deng, G., Yeung, S. K., Cassileth, B. R., Fung, K. P., Leung, P. C., and Lau, C. B. The role of turmerones on curcumin transportation and P-glycoprotein acti
- Pochet S, Lechon AS, Lescrainier C, et al. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Sci Rep 2022;12(1):14178. PubMed
ESTROGENS
4 of 4Cyproterone Acetate, Ethinyl Estradiol also falls under ESTROGENS.
In vitro research shows that curcumin, a constituent of turmeric, displaces the binding of estrogen to its receptors.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Diane-35 pairs ethinyl estradiol (an estrogen) with cyproterone acetate, and it's often prescribed for acne, excess hair growth, and as a contraceptive. The concern with turmeric here is purely theoretical. In lab dish studies, curcumin (turmeric's active compound) was able to nudge estrogen off its receptors. The thinking is that very large amounts could, in theory, slightly blunt the estrogen's activity.
In real life, this is a very low-level concern. The everyday turmeric you cook with won't matter at all, and even concentrated supplements have no solid human evidence of weakening this pill. Still, if you rely on this for birth control, it's worth a quick chat with your pharmacist before taking high-dose curcumin supplements long term.
- Shenouda, N. S., Zhou, C., Browning, J. D., Ansell, P. J., Sakla, M. S., Lubahn, D. B., and MacDonald, R. S. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr.Cancer 2004;49(2):200-208. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Turmeric Also Interacts With Other Medications
Turmeric has 1,055 moderate, 77 minor known drug interactions in our database — the Cyproterone Acetate, Ethinyl Estradiol one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Turmeric
We haven’t checked that one against Turmeric yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Turmeric. Pick one to open its full report.
Questions About Turmeric or Cyproterone Acetate, Ethinyl Estradiol
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Turmeric or Cyproterone Acetate, Ethinyl Estradiol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Turmeric Interact With Amlodipine? ›
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Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Cyproterone Acetate, Ethinyl Estradiol
This page covers Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cyproterone Acetate, Ethinyl Estradiol page lists 211 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 170 moderate · 38 minor.
From our pharmacist’s overview on the Cyproterone Acetate, Ethinyl Estradiol page
“Diane-35 (cyproterone acetate with ethinyl estradiol) is a hormone pill, often used for birth control and acne, so a supplement that weakens it can mean breakthrough bleeding or an unplanned pregnancy. That is why the 211 entries here warrant real care, and the three major ones come first.”
Reviewed by 2 · Jul 18, 2026
Open the Cyproterone Acetate, Ethinyl Estradiol interaction page
Taking Turmeric as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,368 real supplement products containing Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Turmeric. Your product may carry other ingredients that interact with Cyproterone Acetate, Ethinyl Estradiol too, on top of Turmeric — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Turmeric and Cyproterone Acetate, Ethinyl Estradiol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#24 of 1,452 supplements looked up here in the last 7 days
#823 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Turmeric
What is Turmeric?
- Joint pain and arthritis
- Inflammation
- Digestive upset
- Antioxidant support
- Skin conditions
Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain. Some research is promising, but quality is mixed and curcumin is poorly absorbed on its own. For most people, dietary amounts are safe, but talk to your pharmacist or doctor before taking concentrated supplements, especially if you are pregnant, nursing, or have a medical condition.
Other Drugs & Turmeric
Browse every other medication we’ve checked against Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,055 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Tetracycline ›
- Lidocaine ›
- Amoxicillin ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Methyltestosterone ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Allopurinol ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Insulin (human) ›
- Miconazole ›
- Acetaminophen ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
Showing 60 of 1,055 moderate interactions — see all 1,055 on the Turmeric page.
77 interactions
- Theophylline ›
- Propranolol ›
- Ranitidine ›
- Triamcinolone ›
- Apomorphine ›
- Morphine Sulfate ›
- Ivermectin ›
- Lofepramine ›
- Nortriptyline ›
- Betamethasone ›
- Cimetidine ›
- Desipramine ›
- Digoxin ›
- Prucalopride ›
- Asenapine ›
- Clobetasol ›
- Clozapine ›
- Cortisone Acetate ›
- Estropipate ›
- Loperamide ›
- Propafenone ›
- Ropinirole ›
- Triamcinolone Acetonide ›
- Afatinib Dimaleate ›
- Agomelatine ›
- Alvimopan ›
- Apomorphine Hydrochloride ›
- Avatrombopag Maleate ›
- Berotralstat Hydrochloride ›
- Betamethasone Dipropionate ›
- Betamethasone Valerate ›
- Chlordiazepoxide ›
- Dolutegravir ›
- Domperidone ›
- Estrone ›
- Fenfluamine ›
- Fidaxomicin ›
- Fludrocortisone ›
- Fluvoxamine ›
- Givinostat ›
- Loncastuximab Tesirine-lpyl ›
- Lusutrombopag ›
- Mexiletine ›
- Niraparib Tosylate ›
- Olanzapine ›
- Omacetaxine Mepesuccinate ›
- Opicapone ›
- Pentazocine ›
- Pirfenidone ›
- Prasterone (prescription Drug) ›
- Propranolol Hydrochloride ›
- Ranitidine Bismuth Citrate ›
- Rasagiline ›
- Ropivacaine ›
- Rucaparib Camsylate ›
- Sofosbuvir ›
- Talazoparib ›
- Terfenadine ›
- Tibolone ›
- Triclabendazole ›
Showing 60 of 77 minor interactions — see all 77 on the Turmeric page.
No interaction 1,697 drugs checked — show the list
We also checked Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Metoprolol ›
- Escitalopram ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Methamphetamine ›
- Sumatriptan ›
- Lisdexamfetamine ›
- Lisinopril ›
- Bupropion ›
- Acyclovir ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Mannitol ›
- Levetiracetam ›
- Pegunigalsidase Alfa-iwxj ›
- Ezetimibe ›
- Daptomycin ›
- Levothyroxine Sodium ›
- Valsartan ›
- Dexmethylphenidate ›
- Spironolactone ›
- Hexobarbitone ›
- Phentermine, Topiramate ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Hethylphenidate Hcl ›
- Minoxidil ›
- Cefaclor ›
- Venlafaxine ›
- Azelaic Acid ›
- Phenylephrine ›
- Codeine Sulfate ›
- Hydroxychloroquine ›
- Dirithromycin ›
- Pizotifen ›
- Vancomycin ›
- Triptorelin ›
- Bentoquatam ›
- Pentobarbitone ›
- Dextrothyroxine ›
- Procainamide ›
Showing the 60 most looked-up of 1,697 medications checked with no known interaction — see the full Turmeric list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Cyproterone Acetate, Ethinyl Estradiol Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Cyproterone Acetate, Ethinyl Estradiol as a medicine that can lower these. This is not an interaction with Turmeric — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Cyproterone Acetate, Ethinyl Estradiol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Turmeric and Cyproterone Acetate, Ethinyl Estradiol Together: Common Questions
Can you take Turmeric with Cyproterone Acetate, Ethinyl Estradiol?
Why are there 4 interactions listed for Turmeric and Cyproterone Acetate, Ethinyl Estradiol?
How serious is the Turmeric and Cyproterone Acetate, Ethinyl Estradiol interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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